Course of Immunology -introduction Rudolf Horváth Radek Špíšek

Course of Immunology -introduction Rudolf Horváth, Radek Špíšek, Tomáš Milota 2013 email: rudolf. horvath@fnmotol. cz radek. spisek@lfmotol. cuni. cz tomas. milota@fnmotol. cz

Course structure ● Lectures - Presence in lectures is obligatory - Lectures are held every Tuesday at 8: 00 -9: 40 - Three absences are tolerated, more frequent absences must be based on official certificate and written thesis

Date Theme Teacher 1. 10. Immune system, overview. Phagocytic cells, complement. Communication between cells of immune systems, adhesion molecules, prof. Špíšek cytokines. 8. 10. Antigen processing and presentation, HLA I and II class. prof. Šedivá 15. 10. Specific (adaptive) immunity T and B lymphocytes Pharm. Dr. Palich Fučíková 22. 10. Immunity against infection Adkins/Bartůňkov á 29. 10. Immunodeficiency, vaccination prof. Šedivá 5. 11. Immunity against tumors. prof. Špíšek 12. 11. Immunology of transplatation dr. Kalina 19. 11. Autoimmunity. Immunopathology. dr. Kayserová 26. 11. Immunopathological reactions, allergy dr. Kayserová 3. 12. Immunotherapy dr. Podrazil 10. 12. Clinical aspects of immune disorders prof. Bartůňková 17. 12. Case Reports 7. 1. 2014 Case Reports

● Seminars - The first seminar is compulsory; the time of other seminars is devoted to self-studying, preparation of seminar thesis and consultations with teachers.

Seminar thesis ● groups of 1 -2 students ● structure of thesis: - 1000 – 2000 words form of an essay briefly & concisely & interestingly Abstract, text and references (literature) are obligatory, subchapters are recommended ●Term of submission: until 25. 10. 2013 - in the digital form - has to be sent to: irena. novakova@lfmotol. cuni. cz

● Topics of the seminar thesis Basic immunology • • • Regulatory T cells - function and subtypes IL-17, its role in pathologic inflammatory process Immune homeostasis in the gut. Biology of NKT cells. Use of monoclonal antibodies in treatment of tumours. Modulation of the immune system by viruses. Disorders of the immune system • • • Immunology of sepsis Role of Toll-like receptors in autoimmune disease Role of mast cells in the induction of allergic diseases Periodic fevers- genetic background Immunology of coeliac disease. Genetic defects of Toll-like receptor signaling pathways Immunotherapy • • IRAK-4 and My. D 88 deficiency- pathophysiology and clinical presentation Specific and nonspecific immunotherapy of allergy (cellular immunotherapy, cytokines, monoclonal antibodies ) The newest strategies of cancer immunotherapy. Vitamins as regulators of the immune response

● Presentation - each thesis will be presented verbally afterwards on 13. 11 and 20. 11. 2013 (Lecture hall, block G, 3 rd floor) - range: 8 minutes - Powerpoint presentation (6 -10 slides)

Citation „Most of the patients are hemizygous for 22 q 11. 2, some have defects in various loci on chromosome 10, about 10% of cases are familial (2, 3)„ Literature / References: • • 2. DRISCOLL DA, SALVIN J, SELLINGER B, et al. Prevalence of 22 q 11 microdeletions in Di. George and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J Med Genet 1993: 30: 813 -7. 3. SEDIVA A, BARTUNKOVA J, ZACHOVA R, et al. Early development of immunity in di. George syndrome. Med Sci Monit 2005: 11: 182 -7.

Final appraisal ● Presence on lectures ● Seminar thesis: fulfilled / not fulfilled + verbal appraisal (after presentation) ● Verbal examination: 2 out of 50 questions

Evaluation of the essay: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the essay Other comments: Evaluation of the verbal presentation: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the presentation

Sources

Pubmed – Entrez www. pubmed. com • PUBMED • BOOKS • OMIM • Medline Plus – http: //medlineplus. gov/ • TOXNET – http: //toxnet. nlm. nih. gov

Google Scholar http: //scholar. google. com/

Clinical sources on-line • Sum. Search – http: //sumsearch. uthscsa. edu/ • E-medicine – http: //www. emedicine. com/ • Up-to-Date – http: //www. uptodate. com/ • Current Controlled Trials – http: //controlled-trials. com/ • Orphanet – http: //www. orpha. net/

http: //imunologie. lf 2. cuni. cz/ ● shedules ● presentations (download possible) ● recommended literature, links ● contacts