Company profile your partner in sophisticated organic chemistry

Company profile your partner in sophisticated organic chemistry

Where you can find us Dy. Star – Aliachem meeting your partner in sophisticated organic chemistry 2

VUOS ownership AGROFERT HOLDING, a. s. . 100% SYNTESIA, a. s. 100% VÝZKUMNÝ ÚSTAV ORGANICKÝCH SYNTÉZ a. s. (VUOS Dy. Star – Aliachem meeting your partner in sophisticated organic chemistry 3

History Foundation of Research Laboratories Affiliation of Synthesia´s R&D 100% daughter company of Synthesia a. s. New name – VUOS Voucher Privatisation 1941 1952 Dy. Star – Aliachem meeting 1992 1997 2004 prepared for the sale 2009 4

VUOS main businesses 1. R&D and Production of Fine chemicals 2. Toxicology and analytics Emloyees in % 30 45 35 Dy. Star – Aliachem meeting Sales in % 55 R&D Production Toxicology Analytics 45 Others 10 6 14 your partner in sofisticated organic chemistry 70 5

The Certificates of VUOS • ISO 9001: 2001 • Certificate of Good Laboratory Practice • Certificate of Accreditation for Certification of Products No. 229/2002 • Certificate of Accreditation No. 230/2002 Testing Laboratory No. 1057 • Certificate on Compliance with Principles of Good Laboratory Practice • Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory Dy. Star – Aliachem meeting your partner in sofisticated organic chemistry 6

Strong Points • Education structure of employees • VUOS is located in area of long-lasting. chemical tradition with complete infrastructure • Cooperation with University of Pardubice Dy. Star – Aliachem meeting your partner in sofisticated organic chemistry 7

Research & Development • pharmaceutical intermediates • intermediates for microelectronics • custom syntheses of chemical specialities • dyes and pigments for special application Dy. Star – Aliachem meeting your partner in sofisticated organic chemistry 8

Fine Chemicals Production Wide range of quantities Grams – in laboratory Kilograms – in kilolab unit Metric tons plant – in production Hundreds of MT – in Synthesia Dy. Star – Aliachem meeting your partner in Fine Chemicals 9

VUOS's technology / manufacture expertise include: Key know-how and technologies: Adamantanes N-heterocycles Halogen an sulfur derivatives Building Blocks Key chemistry Catalytic hydrogenation Phosgenation Dy. Star – Aliachem meeting your partner in Fine Chemicals 10

VUOS's technology / manufacture expertise include: acetylation aldolisation amidation COOH alkylation amination amoxidation alkali fusion arylhydrazines syntheses azocoupling benzoylation chiral synthesis chlorination chlorosulfonation cyclisation Claisen condensation decarboxylation Dy. Star – Aliachem meeting your partner in Fine Chemicals dehydrohalogenation diazotisation elimination esterification Friedel-Crafts reaction heterocyclic synthesis hydrolysis reactions neutralisation nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride sulfonation 11

Kilolab Unit 2 x reactors, 250 and 650 l Phosgenation Dy. Star – Aliachem meeting 2 x High performance rectification columns your partner in Fine Chemicals 12

Kilolab Unit Hydrogenation 3 x autoclaves 100 l each, 60, 120 and 130 bar, up to 200˚C, Hastelloy C clad 1 x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1 x autoclave 700 l, 100 bar, 200 o. C, stainless steel 1 x autoclave 1, 000 l, 10 bar, 140˚C, stainless steel many autoclaves up to 10 l Dy. Star – Aliachem meeting your partner in Fine Chemicals 13

Kilolab Unit Low temperature, RLi, RMg. X, Na. H 1 x glass reactor 50 l cooled down to – 80˚C 1 x glasslined reactor for Na. H reactions (250 l) 3 x glass reactors 100 l for RLi, Grignard reactions Dy. Star – Aliachem meeting your partner in Fine Chemicals 14

Kilolab Unit Multipurpose chemistry 20 x glass reactors, 100 l each 6 x glass lined reactors (200 – 1, 500 l) 2 x evaporators 50 l / h 4 x stainless steel reactors (300 – 1, 500 l) sufficient filtration and distillation capacity Dy. Star – Aliachem meeting your partner in Fine Chemicals 15

Production Plant Equipment Production Unit 45 x glass lined reactors, total vol. 70, 000 l (500 – 5, 000 l) 13 x stainless steel reactors, total vol. 22, 000 l (1, 000 – 3, 000 l) 8 x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled Dy. Star – Aliachem meeting your partner in Fine Chemicals 16

Toxicology, Ecology and Analytics Dy. Star – Aliachem meeting your partner in Eco/toxicology and Analytics 17

Analytical Techniques: NMR Spectrometry Mass Spectrometry ICP IR Spectroscopy Chromatography UV-VIS Dy. Star – Aliachem meeting your partner in Eco/toxicology and Analytics 18

REACH Complete Offer of Services by VUOS-REACH • CONSULTING • TESTING • REGISTRATION Dy. Star – Aliachem meeting your partner in Eco/toxicology and Analytics 19

Toxicology, Ecology and Analytics • Toxicology / ecotoxicology testing • Sampling, analysing, evaluation of production waste streams (air pollution, effluents, solid wastes hazards) • Environmental Impact Assessment • Development/validation of new specialised analytical methods Dy. Star – Aliachem meeting your partner in Eco/toxicology and Analytics 20

Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550 fax: +420 46 682 2976 e-mail: karel. novak@vuos. com Sales Manager: Miloš Jesenský, Ph. D. Phone: +420 46 682 3300 fax: +420 46 682 2976 e-mail: milos. jesensky@vuos. com R&D : Alois Koloničný, Ph. D. Phone: +420 46 682 3156 fax: +420 46 682 3900 e-mail: alois. kolonicny@vuos. com Toxicology and Analytics: Viktor Mejstřík, Ph. D. Phone: +420 46 682 3127 fax: +420 46 682 2975 e-mail: viktor. mejstrik@vuos. com Process Engineering: Luboš Víšek Phone: +420 46 682 5790 fax: +420 46 682 3900 e-mail: lubos. visek@vuos. com www. vuos. com Dy. Star – Aliachem meeting Our team is ready for co-operation with you 21