COMPANY PROFILE PARTNER FOR COOPERATION VUOS Where

COMPANY PROFILE PARTNER FOR COOPERATION VUOS

Where you can find us 2 2 VUOS – PARTNER FOR COOPERATION

VUOS ownership 3 AGROFERT HOLDING, a. s. 3 100% VUOS – PARTNER FOR COOPERATION SYNTHESIA, a. s. VUOS, a. s. 100%

History 4 r ch ar e ti da n ou F 1941 4 s Re of on La o at or b e – n io OS am a riv P r e h uc Vo 1992 VUOS – PARTNER FOR COOPERATION h nt y f S tio lia ffi s R ia´ o n u er ht g a d A 10 1997 2004 0% m co a sia he &D es t isa t VU n ew N 1952 . s. ies f nt Sy pa o ny

VUOS main businesses 1. R&D and Production of Fine Chemicals 2. Toxicology and Analytics 5 10 6 14 70 Employees 5 VUOS – PARTNER FOR COOPERATION Sales in %

The Certificates of VUOS • Certificate ČSN EN ISO 9001: 2009 (organic chemicals - syntheses development and manufacture) • Decision on Compliance with Principles of Good Manufacturing Practice in Control Laboratory • 6 Certificates of Good Laboratory Practice in Test Facility (OECD GLP Principles - 1997) • Certificate of Accredited Certification Body for Certification of Products (EN 45011: 1998) • Certificate of Accredited Testing Laboratory (EN ISO/IEC 17025: 2005) 6 VUOS – PARTNER FOR COOPERATION

Strong Points • Education structure of employees • VUOS is located in area of long-lasting chemical tradition and complete infrastructure • Cooperation with University of Pardubice 7 Skilled – 25 % Secondary – 30% University degree – 36% Ph. D. degree – 9% 7 VUOS – PARTNER FOR COOPERATION

R&D, upscaling • Pharmaceutical intermediates • Intermediates for microelectronics • Custom syntheses of chemical specialities 8 • Dyes and pigments for special application 8 VUOS – PARTNER FOR COOPERATION

R&D, upscaling Wide range of quantities Grams – in laboratory 9 Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT – 9 VUOS – PARTNER FOR COOPERATION

VUOS ’s key chemistry Adamantane derivatives N-Heterocycles API Building Blocks 10 VUOS ’s key technology Hydrogenation 10 VUOS – PARTNER FOR COOPERATION Phosgenation

VUOS ’s technology/manufacture expertise includes: acetylation dehydrohalogenation aldolisation amidation alkylation amination amoxidation azocoupling benzoylation chiral synthesis chlorination chlorosulfonation Claisen condensation cross coupling reaction cyclisation decarboxylation 11 diazotisation elimination esterification Friedel-Crafts reaction Grignard reaction 11 heterocyclic synthesis hydrolysis reactions neutralisation nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride Sulfonation VUOS – PARTNER FOR COOPERATION

Kilolab and Semi-Pilot Unit Phosgenation 2 x reactors, 250 and 650 l 12 2 x High performance rectification columns Laboratory phosgenation units from 1 to 30 litres 12 VUOS – PARTNER FOR COOPERATION

Kilolab and Semi-Pilot Unit Hydrogenation 3 x autoclaves 100 l each, 60, 120 and 130 13 bar, up to 200 ˚C, Hastelloy C clad 1 x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1 x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1 x autoclave 1 000 l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l 13 VUOS – PARTNER FOR COOPERATION

Kilolab Unit Low temperature, RLi, RMg. X, Na. H 1 x glass reactor 50 l cooled down to – 80 ˚C 1 x glasslined reactor for Na. H reactions (250 l) 3 x glass reactors 100 l for RLi, Grignard reactions 14 VUOS – PARTNER FOR COOPERATION 14

Kilolab and Semi-Pilot Unit Multipurpose chemistry 20 x glass reactors, 100 l each 15 6 x glass lined reactors (200– 1 500 l) 2 x evaporators 50 l / h 4 x stainless steel reactors (300– 1 500 l) sufficient filtration and distillation capacity 15 VUOS – PARTNER FOR COOPERATION

Production Unit Production Equipment 16 45 x glass lined reactors, total vol. 70 000 l (500– 5 000 l) 13 x stainless steel reactors, total vol. 22 000 l (1 000– 3, 000 l) 8 x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled 16 VUOS – PARTNER FOR COOPERATION

Toxicology, Ecotoxicology and Analytics 17 17 VUOS – PARTNER FOR COOPERATION

Toxicology, Ecotoxicology and Analytics REACH and CLP Services • Literature search • Preparation of dossiers in IUCLID 5 18 • Preparation of Chemical Safety Report • Non-testing approaches • (Q)SAR • Grouping/Read-across • • 18 Preparation of SDS Classification of substances and mixtures VUOS – PARTNER FOR COOPERATION

Toxicology, Ecotoxicology and Analytics Analytical methods • • Mass Spectrometry (LC/GC-MS) • ICP-AES • IR Spectrometry • Chromatography (HPLC, GC) • 19 NMR Spectrometry UV-VIS VUOS – PARTNER FOR COOPERATION 19

Toxicology, Ecotoxicology and Analytics Toxicological tests In vivo and in vitro tests according to the OECD or EU methods: • • Skin and Eye irritation • Sensibilisation • Repeated dose toxicity • Reproductive toxicity • Carcinogenicity • 20 Acute toxicity Mutagenicity VUOS – PARTNER FOR COOPERATION 20

Toxicology, Ecotoxicology and Analytics Ecotoxicological tests • Aquatic toxicity • Biotic degradation • Abiotic degradation • Adsorption/desorption Physico-chemical tests • Information on physicochemical properties of substance 21 VUOS – PARTNER FOR COOPERATION 21

Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550, fax: +420 46 682 2976 e-mail: karel. novak@vuos. com Sales Manager: Miloš Jesenský, Ph. D. Phone: +420 46 682 3300, fax: +420 46 682 2976 e-mail: milos. jesensky@vuos. com R&D: Alois Koloničný, Ph. D. 22 Phone: +420 46 682 3156, fax: +420 46 682 3900 e-mail: alois. kolonicny@vuos. com Toxicology and Analytics: Viktor Mejstřík, Ph. D. Phone: +420 46 682 3127, fax: +420 46 682 2975 e-mail: viktor. mejstrik@vuos. com Process Engineering: Luboš Víšek Phone: +420 46 682 5790, fax: +420 46 682 3900 e-mail: lubos. visek@vuos. com 22 VUOS – PARTNER FOR COOPERATION

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