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COMPANY PROFILE PARTNER FOR COOPERATION VUOS COMPANY PROFILE PARTNER FOR COOPERATION VUOS

Where you can find us 2 2 VUOS – PARTNER FOR COOPERATION Where you can find us 2 2 VUOS – PARTNER FOR COOPERATION

VUOS ownership 3 AGROFERT HOLDING, a. s. 3 100% VUOS – PARTNER FOR COOPERATION VUOS ownership 3 AGROFERT HOLDING, a. s. 3 100% VUOS – PARTNER FOR COOPERATION SYNTHESIA, a. s. VUOS, a. s. 100%

History 4 4 VUOS – PARTNER FOR COOPERATION History 4 4 VUOS – PARTNER FOR COOPERATION

VUOS main businesses 1. R&D and Production of Fine Chemicals 2. Toxicology and Analytics VUOS main businesses 1. R&D and Production of Fine Chemicals 2. Toxicology and Analytics 5 Employees 5 VUOS – PARTNER FOR COOPERATION Sales in %

The Certificates of VUOS • ISO 9001: 2008 • Certificates of Good Laboratory Practice The Certificates of VUOS • ISO 9001: 2008 • Certificates of Good Laboratory Practice • Certificate of Accreditation for Certification of Products No. 229/2002 (EN 45011: 1998) • Certificate of Accreditation No. 6 230/2002 Testing Laboratory No. 1057 (EN ISO/IEC 17025: 2005) • Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory 6 VUOS – PARTNER FOR COOPERATION

Strong Points • Education structure of employees • • 7 VUOS is located in Strong Points • Education structure of employees • • 7 VUOS is located in area of long-lasting tradition and complete infrastructure Cooperation with University of Pardubice VUOS – PARTNER FOR COOPERATION 7 chemical

R&D, up scaling • Pharmaceutical intermediates • Intermediates for microelectronics • Custom syntheses of R&D, up scaling • Pharmaceutical intermediates • Intermediates for microelectronics • Custom syntheses of chemical specialities 8 • Dyes and pigments for special application 8 VUOS – PARTNER FOR COOPERATION

R&D, up scaling Wide range of quantities Grams – in laboratory 9 Kilograms – R&D, up scaling Wide range of quantities Grams – in laboratory 9 Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT – 9 VUOS – PARTNER FOR COOPERATION

VUOS ’s key chemistry Adamantane derivatives N-Heterocycles API Building Blocks 10 VUOS ’s key VUOS ’s key chemistry Adamantane derivatives N-Heterocycles API Building Blocks 10 VUOS ’s key technology Hydrogenation 10 VUOS – PARTNER FOR COOPERATION Phosgenation

VUOS ’s technology/manufacture expertise includes: acetylation dehydrohalogenation aldolisation amidation alkylation amination amoxidation alkali fusion VUOS ’s technology/manufacture expertise includes: acetylation dehydrohalogenation aldolisation amidation alkylation amination amoxidation alkali fusion arylhydrazines syntheses azocoupling benzoylation chiral synthesis chlorination chlorosulfonation cyclisation claisen condensation decarboxylation 11 diazotisation elimination esterification Friedel-Crafts reaction heterocyclic synthesis 11 hydrolysis reactions neutralisation nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride sulfonation VUOS – PARTNER FOR COOPERATION

Kilolab Unit Phosgenation 2 x reactors, 250 and 650 l 12 2 x High Kilolab Unit Phosgenation 2 x reactors, 250 and 650 l 12 2 x High performance rectification columns Laboratory phosgenation units from 1 to 30 litres 12 VUOS – PARTNER FOR COOPERATION

Kilolab Unit Hydrogenation 3 x autoclaves 100 l each, 60, 120 and 130 13 Kilolab Unit Hydrogenation 3 x autoclaves 100 l each, 60, 120 and 130 13 bar, up to 200 ˚C, Hastelloy C clad 1 x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1 x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1 x autoclave 1 000 l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l 13 VUOS – PARTNER FOR COOPERATION

Kilolab Unit Low temperature, RLi, RMg. X, Na. H 1 x glass reactor 50 Kilolab Unit Low temperature, RLi, RMg. X, Na. H 1 x glass reactor 50 l cooled down to – 80 ˚C 1 x glasslined reactor for Na. H reactions (250 l) 3 x glass reactors 100 l for RLi, Grignard reactions 14 VUOS – PARTNER FOR COOPERATION 14

Kilolab Unit Multipurpose chemistry 20 x glass reactors, 100 l each 15 6 x Kilolab Unit Multipurpose chemistry 20 x glass reactors, 100 l each 15 6 x glass lined reactors (200– 1 500 l) 2 x evaporators 50 l / h 4 x stainless steel reactors (300– 1 500 l) sufficient filtration and distillation capacity 15 VUOS – PARTNER FOR COOPERATION

Production Unit Production Equipment 16 45 x glass lined reactors, total vol. 70 000 Production Unit Production Equipment 16 45 x glass lined reactors, total vol. 70 000 l (500– 5 000 l) 13 x stainless steel reactors, total vol. 22 000 l (1 000– 3, 000 l) 8 x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled 16 VUOS – PARTNER FOR COOPERATION

Toxicology, Ecology and Analytics 17 17 VUOS – PARTNER FOR COOPERATION Toxicology, Ecology and Analytics 17 17 VUOS – PARTNER FOR COOPERATION

REAC H and other legislative provisions Complete Offer of Services by VUOS • CONSULTING REAC H and other legislative provisions Complete Offer of Services by VUOS • CONSULTING • TESTING – Physico – chemical tests – Toxicological tests – Ecotoxicological tests • EXPERT WORKS • REGISTRATION 18 VUOS – PARTNER FOR COOPERATION 18

Toxicology, Ecology and Analytics Analytical techniques: • • • 19 NMR Spectroscopy Mass Spectrometry Toxicology, Ecology and Analytics Analytical techniques: • • • 19 NMR Spectroscopy Mass Spectrometry (LC/GC-MS) ICP-AES IR Spectroscopy Chromatography (HPLC, GC) UV-Vis VUOS – PARTNER FOR COOPERATION 19

Toxicology, Ecology and Analytics Toxicology: In vivo and in vitro testing according to the Toxicology, Ecology and Analytics Toxicology: In vivo and in vitro testing according to the OECD or EU methods: • • Skin and eye irritation • Sensibilisation • Repeated dose tests • Reproduction toxicity tests • Carcinogenicity • 20 Acute toxicity test Mutagenicity VUOS – PARTNER FOR COOPERATION 20

Toxicology, Ecology and Analytics Ecotoxicological testing: In vivo and in vitro testing according to Toxicology, Ecology and Analytics Ecotoxicological testing: In vivo and in vitro testing according to the OECD or EU methods: • • • Inherent biodegradability • 21 Aquatic toxicity Biotic degradation Ready biodegradability Abiotic degradation VUOS – PARTNER FOR COOPERATION 21 –

Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550, fax: +420 46 Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550, fax: +420 46 682 2976 e-mail: karel. [email protected] com Sales Manager: Miloš Jesenský, Ph. D. Phone: +420 46 682 3300, fax: +420 46 682 2976 e-mail: milos. [email protected] com R&D: Alois Koloničný, Ph. D. 22 Phone: +420 46 682 3156, fax: +420 46 682 3900 e-mail: alois. [email protected] com Toxicology and Analytics: Viktor Mejstřík, Ph. D. Phone: +420 46 682 3127, fax: +420 46 682 2975 e-mail: viktor. [email protected] com Process Engineering: Luboš Víšek Phone: +420 46 682 5790, fax: +420 46 682 3900 e-mail: lubos. [email protected] com 22 VUOS – PARTNER FOR COOPERATION

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