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COMPANY PROFILE PARTNER FOR COOPERATION VUOS COMPANY PROFILE PARTNER FOR COOPERATION VUOS

Where you can find us 2 2 VUOS – PARTNER FOR COOPERATION Where you can find us 2 2 VUOS – PARTNER FOR COOPERATION

VUOS ownership 3 AGROFERT HOLDING, a. s. 3 100% VUOS – PARTNER FOR COOPERATION VUOS ownership 3 AGROFERT HOLDING, a. s. 3 100% VUOS – PARTNER FOR COOPERATION SYNTHESIA, a. s. VUOS, a. s. 100%

History 4 r ch ar e ti da n ou F 1941 4 s History 4 r ch ar e ti da n ou F 1941 4 s Re of on La o at or b e – n io OS am a riv P r e h uc Vo 1992 VUOS – PARTNER FOR COOPERATION h nt y f S tio lia ffi s R ia´ o n u er ht g a d A 10 1997 2004 0% m co a sia he &D es t isa t VU n ew N 1952 . s. ies f nt Sy pa o ny

VUOS main businesses 1. R&D and Production of Fine Chemicals 2. Toxicology and Analytics VUOS main businesses 1. R&D and Production of Fine Chemicals 2. Toxicology and Analytics 5 10 6 14 70 Employees 5 VUOS – PARTNER FOR COOPERATION Sales in %

The Certificates of VUOS • Certificate ČSN EN ISO 9001: 2009 (organic chemicals - The Certificates of VUOS • Certificate ČSN EN ISO 9001: 2009 (organic chemicals - syntheses development and manufacture) • Certificate of Good Manufacturing Practice (GMP) • Certificates of Good Laboratory Practice in Test Facility (OECD GLP Principles - 1997) • 6 Certificate of Accredited Certification Body for Certification of Products (EN 45011: 1998) • Certificate of Accredited Testing Laboratory (EN ISO/IEC 17025: 2005) 6 VUOS – PARTNER FOR COOPERATION

Strong Points • Education structure of employees • VUOS is located in area of Strong Points • Education structure of employees • VUOS is located in area of long-lasting chemical tradition and complete infrastructure • Cooperation with University of Pardubice 7 Skilled – 25 % Secondary – 30% University degree – 36% Ph. D. degree – 9% 7 VUOS – PARTNER FOR COOPERATION

R&D, upscaling • Pharmaceutical intermediates also under GMP standard 8 • Intermediates for microelectronics R&D, upscaling • Pharmaceutical intermediates also under GMP standard 8 • Intermediates for microelectronics • Custom syntheses of chemical specialities • Dyes and pigments for special application 8 VUOS – PARTNER FOR COOPERATION

R&D, upscaling Wide range of quantities Grams – in laboratory 9 Kilograms – in R&D, upscaling Wide range of quantities Grams – in laboratory 9 Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT – 9 VUOS – PARTNER FOR COOPERATION

VUOS key chemistry Adamantane derivatives N-Heterocycles API Building Blocks 10 VUOS ’s key technology VUOS key chemistry Adamantane derivatives N-Heterocycles API Building Blocks 10 VUOS ’s key technology Hydrogenation 10 VUOS – PARTNER FOR COOPERATION Phosgenation

VUOS technology/manufacture expertise includes: Organometallic and Cryogenic Chemistry • • Organolithium Chemistry Organozinc Chemistry VUOS technology/manufacture expertise includes: Organometallic and Cryogenic Chemistry • • Organolithium Chemistry Organozinc Chemistry Grignards Sodium Hydride Reactions Transition-Metal Catalysis • Homogeneous and Heterogeneous Transition-Metal Catalysis • Cross Couplings (Suzuki, Kumada, Heck, etc. ) 11 Hazardous and Unpleasant Chemistry • • • Phosgenation Halogenation (PCl 3, POCl 3, SOCl 2, BCl 3, BBr 3, etc. ) Rections with Nitroalkanes Nitration Sulfonation Reduction and High-Pressure Hydrogenations • • • 11 Reduction with Sodium borohydride, Red-Al, Superhydride, etc. Reductive Alkylation Reductive Amination Hydrogenolysis Dehalogenation VUOS – PARTNER FOR COOPERATION

Kilolab and Production Unit Phosgenation Reactors up to 1 600 l 2 x High Kilolab and Production Unit Phosgenation Reactors up to 1 600 l 2 x High performance rectification columns Laboratory phosgenation units from 1 to 30 l 12 VUOS – PARTNER FOR COOPERATION 12

Kilolab and Semi-Pilot Unit Hydrogenation 3 x autoclaves 100 l each, 60, 120 and Kilolab and Semi-Pilot Unit Hydrogenation 3 x autoclaves 100 l each, 60, 120 and 130 13 bar, up to 200 ˚C, Hastelloy C clad 1 x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1 x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1 x autoclave 1 000 l, 10 bar, 140 ˚C, stainless steel many small autoclaves up to 10 l 13 VUOS – PARTNER FOR COOPERATION

Kilolab and Production Unit Low temperature, RLi, RMg. X, Na. H Reactors up to Kilolab and Production Unit Low temperature, RLi, RMg. X, Na. H Reactors up to 630 l cooled down to – 80 ˚C 1 x glass-lined reactor for Na. H reactions (250 l) 3 x glass reactors 100 l cooled down to – 40°C 14 VUOS – PARTNER FOR COOPERATION 14

Kilolab and Semi-Pilot Unit Multipurpose chemistry 15 20 x glass reactors, 100 l each Kilolab and Semi-Pilot Unit Multipurpose chemistry 15 20 x glass reactors, 100 l each 6 x glass lined reactors (200– 1 500 l) 2 x evaporators 50 l / h 4 x stainless steel reactors (300– 1 500 l) sufficient filtration and distillation capacity 15 VUOS – PARTNER FOR COOPERATION

GMP Production Line Production of API, advanced intermediates, controlled finalization 16 Glass-lined vessels 400 GMP Production Line Production of API, advanced intermediates, controlled finalization 16 Glass-lined vessels 400 and 630 l Stainless steel vessels 400 and 630 l Filtration, Centrifuging and Drying 16 VUOS – PARTNER FOR COOPERATION

Production Unit Production Equipment 17 52 x glass lined reactors, total vol. 85 000 Production Unit Production Equipment 17 52 x glass lined reactors, total vol. 85 000 l (500 – 6 000 l) 16 x stainless steel reactors, total vol. 29 000 l (1 000– 6 000 l) 8 x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled 17 VUOS – PARTNER FOR COOPERATION

New Production Unit dedicated for production of Pharma Intermediates Purpose 18 Dedicated for the New Production Unit dedicated for production of Pharma Intermediates Purpose 18 Dedicated for the production of pharma intermediates under GMP standard 5 reactors , total volume 10 000 l, stainless steel and glass lined Filtration, distillation, drying Supposed to be ready in the year 2018 Investment cost 4 mil. EUR 18 VUOS – PARTNER FOR COOPERATION

New Unit dedicated for grinding, drying and blending of dry materials Purpose Dedicated for New Unit dedicated for grinding, drying and blending of dry materials Purpose Dedicated for the for grinding, blending and drying of pharma intermediates under GMP standard 3 tray dryers in separate rooms with separate ventilation Equipment for grinding and blending Investment cost 1 mil. EUR 19 VUOS – PARTNER FOR COOPERATION 19

Toxicology, Ecotoxicology and Analytics 20 20 VUOS – PARTNER FOR COOPERATION Toxicology, Ecotoxicology and Analytics 20 20 VUOS – PARTNER FOR COOPERATION

Toxicology, Ecotoxicology and Analytics REACH and CLP Services • Literature search • Preparation of Toxicology, Ecotoxicology and Analytics REACH and CLP Services • Literature search • Preparation of dossiers in IUCLID 5 21 • Preparation of Chemical Safety Report • Non-testing approaches • (Q)SAR • Grouping/Read-across • • 21 Preparation of SDS Classification of substances and mixtures VUOS – PARTNER FOR COOPERATION

Toxicology, Ecotoxicology and Analytics Analytical methods • • Mass Spectrometry (LC/GC-MS) • ICP-AES • Toxicology, Ecotoxicology and Analytics Analytical methods • • Mass Spectrometry (LC/GC-MS) • ICP-AES • IR Spectrometry • Chromatography (HPLC, GC) • 22 NMR Spectrometry UV-VIS VUOS – PARTNER FOR COOPERATION 22

Toxicology, Ecotoxicology and Analytics Toxicological tests In vivo and in vitro tests according to Toxicology, Ecotoxicology and Analytics Toxicological tests In vivo and in vitro tests according to the OECD or EU methods: • • Skin and Eye irritation • Sensibilisation • Repeated dose toxicity • Reproductive toxicity • Carcinogenicity • 23 Acute toxicity Mutagenicity VUOS – PARTNER FOR COOPERATION 23

Toxicology, Ecotoxicology and Analytics Ecotoxicological tests • Aquatic toxicity • Biotic degradation • Abiotic Toxicology, Ecotoxicology and Analytics Ecotoxicological tests • Aquatic toxicity • Biotic degradation • Abiotic degradation • Adsorption/desorption 24 Physico-chemical tests • Information on physicochemical properties of substance 24 VUOS – PARTNER FOR COOPERATION

Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550 e-mail: karel. novak@vuos. Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550 e-mail: karel. [email protected] com Sales Manager: Miloš Jesenský, Ph. D. Phone: +420 46 682 3300 e-mail: milos. [email protected] com R&D: Pavel Holý, Ph. D. Phone: +420 46 682 3156 e-mail: pavel. [email protected] com 25 Analytics: Michal Bartoš Phone: +420 46 682 2501 e-mail: michal. [email protected] com Toxicology Phone: +420 724 400 557 e-mail: petra. [email protected] com 25 VUOS – PARTNER FOR COOPERATION

26 26 Výzkumný ústav organických syntéz a. s. Rybitví č. p. 296, 533 54 26 26 Výzkumný ústav organických syntéz a. s. Rybitví č. p. 296, 533 54 Rybitví, Czech Republic www. vuos. com