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Cognitive Behavioral Treatment of Panic Disorder The original version of these slides was provided Cognitive Behavioral Treatment of Panic Disorder The original version of these slides was provided by Michael W. Otto, Ph. D. & Heather W. Murray, Ph. D. , with support from NIMH Excellence in Training Award at the Center for Anxiety and Related Disorders at Boston University (R 25 MH 08478)

Use of this Slide Set • Presentation information is listed in the notes section Use of this Slide Set • Presentation information is listed in the notes section below the slide (in Power. Point normal viewing mode). • A bibliography for this slide set is provided below in the note section for this slide. • References are also provided in note sections for select subsequent slides

Panic Disorder Diagnostic Considerations Panic Disorder Diagnostic Considerations

DSM Panic Attacks: Defined by 4 or more of the following 13 symptoms 11 DSM Panic Attacks: Defined by 4 or more of the following 13 symptoms 11 Somatic Symptoms • Increased heart rate • Shortness of breath • Chest pain • Choking sensation • Trembling • Sweating • Nausea • Dizziness • Numbness/Tingling • Hot flashes or chills • Depersonalization 2 Cognitive Symptoms • Fear of dying • Fear of losing control

Panic Disorder • Recurrent unexpected panic attacks Criterion B • Worry about future attacks Panic Disorder • Recurrent unexpected panic attacks Criterion B • Worry about future attacks • Worry about the consequences of the attack (i. e. , having a heart attack) • Substantial behavioral changes in response to the attacks

Agoraphobia • Anxiety about being in situations related to perceived inability to escape or Agoraphobia • Anxiety about being in situations related to perceived inability to escape or get help if a panic attack occurs • Situations are avoided or endured with significant distress

Core Patterns in Panic Disorder • Fears of symptoms of anxiety (anxiety sensitivity) – Core Patterns in Panic Disorder • Fears of symptoms of anxiety (anxiety sensitivity) – Risk for onset of panic attacks – Risk for biological provocation of panic – Risk for panic disorder relapse (Mc. Nally , 2002)

Common Catastrophic Thoughts in Panic Disorder • Fears of death or disability – Am Common Catastrophic Thoughts in Panic Disorder • Fears of death or disability – Am I having a heart attack? – I am having a stroke! – I am going to suffocate! • Fears of losing control/insanity – I am going to lose control and scream – I am having a nervous breakdown – If I don’t escape, I will go crazy • Fears of humiliation or embarrassment – People will think something is wrong with me – They will think I am a lunatic – I will faint and be embarrassed

Cognitive-Behavioral Model of Panic Disorder Stress Biological Diathesis Alarm Reaction Rapid heart rate, heart Cognitive-Behavioral Model of Panic Disorder Stress Biological Diathesis Alarm Reaction Rapid heart rate, heart palpitations Shortness of breath, smothering sensations Chest pain or discomfort, numbness or tingling Increased anxiety and fear Conditioned Fear of Somatic Sensations Catastrophic misinterpretations of symptoms Hypervigilance to symptoms Anticipatory anxiety Memory of past attacks

Case example • Abby, a 29 year old female, reports unexpected panic attacks and Case example • Abby, a 29 year old female, reports unexpected panic attacks and describes increased heart rate, lightheadedness, shortness of breath, and tingling sensations in her arms. When she experiences these episodes, she believes that she is going to faint; she describes fainting as both embarrassing and dangerous. She worries about having these episodes when in public places and places where getting help would be difficult. Because of her fear, she avoids going to public places alone and always carries her cell phone in case she needs to call for help.

Elements of Cognitive Behavior Therapy for Panic Disorder Elements of Cognitive Behavior Therapy for Panic Disorder

Core Elements of CBT • • Psychoeducation/ Informational intervention Cognitive interventions Interoceptive (internal) exposure Core Elements of CBT • • Psychoeducation/ Informational intervention Cognitive interventions Interoceptive (internal) exposure In vivo exposure • Can be delivered in individual or group treatment formats

Information Interventions • May include handouts or patient manuals • Distinguishes between symptoms, thoughts, Information Interventions • May include handouts or patient manuals • Distinguishes between symptoms, thoughts, and behaviors – and introduces the cascade between these elements • Introduces the notion and consequences of catastrophic thoughts • Addresses the role of escape and avoidance in maintaining fear • Helps the patient adopt an informed and active role in treatment

Cognitive Restructuring - General • Identify the nature of thoughts: they don’t have to Cognitive Restructuring - General • Identify the nature of thoughts: they don’t have to be true to affect emotions • Learn about common biases in thoughts • Treat thoughts as “guesses” or “hypotheses” about the world

Cognitive Restructuring - Specific • Increase awareness of thinking patterns – Over-estimating the probability Cognitive Restructuring - Specific • Increase awareness of thinking patterns – Over-estimating the probability of negative outcomes – Assuming the consequence will be unmanageable • Monitor relationship between thinking and panic episodes • Challenge thinking – Evaluating evidence for the thought – Evaluating the cost of the feared outcome • Establish adaptive thinking patterns – Reality based thinking and not just positive thinking

Exposure Interventions • Provide rationale for confronting feared situations • Establish a hierarchy of Exposure Interventions • Provide rationale for confronting feared situations • Establish a hierarchy of feared situations • Provide accurate expectations • Repeat exposure until fear diminishes • Attend to the disconfirmation of fears (“What was learned from the exposure? ”)

Interoceptive Exposures (exposures to internal sensations) Rationale: • Provide opportunities to examine negative predictions Interoceptive Exposures (exposures to internal sensations) Rationale: • Provide opportunities to examine negative predictions about internal sensations • Provide opportunities to increasing tolerance to and acceptance of internal sensations though repeated exposure to sensations Method: • Engage in systematic exercises that induce feared internal sensations (i. e. , dizziness, increased heart rate).

Common Interoceptive Exposure Procedures • Headrolling – 30 seconds - dizziness, disorientation • Hyperventilation Common Interoceptive Exposure Procedures • Headrolling – 30 seconds - dizziness, disorientation • Hyperventilation – 1 minute - produces dizziness lightheadedness, numbness, tingling, hot flushes, visual distortion • Stair running – a few flights – produces breathlessness, a pounding heart, heavy legs, trembling • Full body tension – 1 minute – produces trembling, heavy muscles, numbness • Chair spinning – several times around – produces strong dizziness, disorientation • Mirror (or hand) staring – 1 minute – produces derealization

Panic Cycle Uh oh! What if: • This gets worse? • I lose control? Panic Cycle Uh oh! What if: • This gets worse? • I lose control? • This is a stroke? I have to control this! Relative Comfort • Notice the sensation • Do nothing to control it. • Relax WITH the sensation

Learning Safety in Panic Interoceptive exposure • Feared sensations become safe sensations – in Learning Safety in Panic Interoceptive exposure • Feared sensations become safe sensations – in the office with therapist – at home – independent of the treatment context

Situational Exposures • Rationale: – Providing a new learning opportunity to examine negative predictions Situational Exposures • Rationale: – Providing a new learning opportunity to examine negative predictions about feared outcomes – Increasing tolerance to internal sensations in feared situations

Situational Exposure Guidelines • Prior to completing in-vivo exposures, create a fear hierarchy identifying Situational Exposure Guidelines • Prior to completing in-vivo exposures, create a fear hierarchy identifying feared and avoided situations • Identify safety behaviors- actions taken to avoid, prevent, or manage a potential threat – Avoidance – Checking (pulse, exits, hospitals) – Carrying aids (rescue medications, cellular phones)

Application of CBT • An effective first-line treatment • A replacement strategy for medication Application of CBT • An effective first-line treatment • A replacement strategy for medication treatment (medication discontinuation) • In combination with medication treatment – Treatment resistance – Standard strategy

CBT for Panic Disorder And it is acceptable, tolerable, and cost effective CBT for Panic Disorder And it is acceptable, tolerable, and cost effective

Meta-Analytic Results of Panic Disorder Treatment Studies Effect Size (Cohen’s d) CBT (IE+CR) CBT Meta-Analytic Results of Panic Disorder Treatment Studies Effect Size (Cohen’s d) CBT (IE+CR) CBT Non-SSRI Antidepressants Benzodiazepines SSRIs Antidepressants Gould et al, 1995; Otto et al. , 2001

CBT for Panic Disorder In addition to core panic, anxiety, and avoidance outcomes, CBT CBT for Panic Disorder In addition to core panic, anxiety, and avoidance outcomes, CBT has broader-based benefits, including: • Improvements in quality of life • Improvement in comorbid conditions (e. g. , Allen et al. , 2010; Telch et al. , 1995; Tsao et al. , 1998)

Percent Dropout Treatment Acceptability (dropout rates) Percent Dropout Treatment Acceptability (dropout rates)

Treatment Acceptability Percent Refusal Rate in the Multicenter Panic Trial Treatment Hofmann SG, et Treatment Acceptability Percent Refusal Rate in the Multicenter Panic Trial Treatment Hofmann SG, et al. Am J Psychiatry. 1998; 155: 43 -47.

Strategies to Enhance CBT • Combination with standard pharmacotherapy (CBT plus antidepressants or benzodiazepines) Strategies to Enhance CBT • Combination with standard pharmacotherapy (CBT plus antidepressants or benzodiazepines) – Some acute benefits – Benefits lost with medication discontinuation • Novel combination treatment – Memory enhancers

% Responders (40% PDSS) Panic Disorder: Continuation Treatment Maintenance (ITT) 6 More Months Barlow % Responders (40% PDSS) Panic Disorder: Continuation Treatment Maintenance (ITT) 6 More Months Barlow DH, et al. JAMA. 2000; 283: 2529 -2536.

% Responders (40% PDSS) Panic Disorder: Post–Imipramine Discontinuation 6 Months Treatment Discontinuation (ITT) (Imipramine % Responders (40% PDSS) Panic Disorder: Post–Imipramine Discontinuation 6 Months Treatment Discontinuation (ITT) (Imipramine over 1 to 2 weeks) Barlow DH, et al. JAMA. 2000; 283: 2529 -2536.

Panic Disorder: After 8 Weeks of Treatment Effect Size (CGI relative to PR) EXP Panic Disorder: After 8 Weeks of Treatment Effect Size (CGI relative to PR) EXP = exposure treatment. ALP = alprazolam treatment. PBO = placebo treatment. Relax = relaxation treatment. Marks IM et al. Br J Psychiatry. 1993; 162: 776 -787.

Panic Disorder: Post Benzodiazepine Discontinuation (Week 18) Effect Size (CGI relative to PR) EXP Panic Disorder: Post Benzodiazepine Discontinuation (Week 18) Effect Size (CGI relative to PR) EXP = exposure treatment. ALP = alprazolam treatment. PBO = placebo treatment. Relax = relaxation treatment. Marks IM et al. Br J Psychiatry. 1993; 162: 776 -787.

The Solution • Apply (re-apply) CBT at the time of medication taper and thereafter The Solution • Apply (re-apply) CBT at the time of medication taper and thereafter • Remember, it works for medication discontinuation with expansion of treatment gains – Treatment with benzodiazepines 1, 2 – Treatment with SSRIs 3, 4 1 Otto MW et al. Psychopharmacol Bull. 1992; 28: 123 -130. 2 Spiegel DA et al. Am J Psychiatry. 1994; 151: 876 -881. 3 Schmidt NB et al. Behav Res Ther. 2002; 40: 67 -73. 4 Whittal ML et al. Behav Res Ther. 2001; 39: 939 -945.

Greater success with a novel combination strategy • Combination of CBT with the putative Greater success with a novel combination strategy • Combination of CBT with the putative memory enhancer, d-cycloserine • 2 small treatment trials suggest that d-cycloserine helps consolidate therapeutic learning from exposure, helping speed treatment outcome • Similar benefits for d-cycloserine + exposure is seen for other anxiety disorders

Preventive Treatment • Target a putative risk factor for Panic Disorder (anxiety sensitivity) • Preventive Treatment • Target a putative risk factor for Panic Disorder (anxiety sensitivity) • 5 -hour prevention workshop: – – Psychoeducation Cognitive restructuring Interoceptive exposure Instruction for in vivo exposure Gardenswartz CA, Craske MG. Behav Ther. 2001; 32: 725 -738.

% Developing Panic Disorder Preventive Treatment 121 Participants Gardenswartz CA, Craske MG. Behav Ther. % Developing Panic Disorder Preventive Treatment 121 Participants Gardenswartz CA, Craske MG. Behav Ther. 2001; 32: 725 -738.

Exporting Treatment: Benchmarking Research • CBT for panic disorder can be transported to a Exporting Treatment: Benchmarking Research • CBT for panic disorder can be transported to a community setting and achieve effectiveness in accordance with expectations from clinical trials Wade WA, et al. J Consult Clin Psychol. 1998; 66: 231 -239.