Chapter 14 Autonomic Nervous System The Autonomic Nervous

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>Chapter 14 Autonomic Nervous System Chapter 14 Autonomic Nervous System

>The Autonomic Nervous System Regulates activity of smooth muscle, cardiac muscle & certain glands The Autonomic Nervous System Regulates activity of smooth muscle, cardiac muscle & certain glands Structures involved general visceral afferent neurons general visceral efferent neurons integration center within the brain

>The Autonomic Nervous System Receives input from limbic system and other regions of the The Autonomic Nervous System Receives input from limbic system and other regions of the cerebrum

>Autonomic versus Somatic NS Somatic nervous system consciously perceived sensations excitation of skeletal muscle Autonomic versus Somatic NS Somatic nervous system consciously perceived sensations excitation of skeletal muscle one neuron connects CNS to organ

>Autonomic versus Somatic NS Autonomic nervous system unconsciously perceived visceral sensations  involuntary inhibition Autonomic versus Somatic NS Autonomic nervous system unconsciously perceived visceral sensations involuntary inhibition or excitation of smooth muscle, cardiac muscle or glandular secretion two neurons needed to connect CNS to organ preganglionic and postganglionic neurons

>Autonomic versus Somatic NS Notice that the ANS pathway is a 2 neuron pathway Autonomic versus Somatic NS Notice that the ANS pathway is a 2 neuron pathway while the Somatic NS only contains one neuron.

>Basic Anatomy of ANS Preganglionic neuron cell body in brain or spinal cord Basic Anatomy of ANS Preganglionic neuron cell body in brain or spinal cord axon is myelinated type B fiber that extends to autonomic ganglion Postganglionic neuron cell body lies outside the CNS in an autonomic ganglion axon is unmyelinated type C fiber that terminates in a visceral effector

>Divisions of the ANS 2 major divisions parasympathetic sympathetic Dual innervation one speeds up Divisions of the ANS 2 major divisions parasympathetic sympathetic Dual innervation one speeds up organ one slows down organ Sympathetic NS increases heart rate Parasympathetic NS decreases heart rate

>Divisions of the ANS Parasympathetic D division digestion defecation diuresis (urination) Sympathetic E division Divisions of the ANS Parasympathetic D division digestion defecation diuresis (urination) Sympathetic E division exercise excitement emergency embarrassment

>Sources of Dual Innervation Sympathetic (thoracolumbar) division preganglionic  cell bodies in thoracic and Sources of Dual Innervation Sympathetic (thoracolumbar) division preganglionic cell bodies in thoracic and first 2 lumbar segments of spinal cord Parasympathetic (craniosacral) division preganglionic cell bodies in nuclei of 4 cranial nerves and the sacral spinal cord

>Locations of Autonomic Ganglia Sympathetic Ganglia trunk (chain) ganglia near vertebral bodies prevertebral ganglia Locations of Autonomic Ganglia Sympathetic Ganglia trunk (chain) ganglia near vertebral bodies prevertebral ganglia near large blood vessel in gut celiac superior mesenteric inferior mesenteric Parasympathetic Ganglia terminal ganglia in wall of organ

>Autonomic Plexuses Cardiac plexus Pulmonary plexus Celiac (solar) plexus Superior mesenteric Inferior mesenteric Hypogastric Autonomic Plexuses Cardiac plexus Pulmonary plexus Celiac (solar) plexus Superior mesenteric Inferior mesenteric Hypogastric

>Organs Innervated by Sympathetic NS Structures innervated by each spinal nerve sweat glands, arrector Organs Innervated by Sympathetic NS Structures innervated by each spinal nerve sweat glands, arrector pili mm., blood vessels to skin & skeletal mm. Thoracic & cranial plexuses supply: heart, lungs, esophagus & thoracic blood vessels plexus around carotid artery to head structures Splanchnic nerves to prevertebral ganglia supply: GI tract from stomach to rectum, urinary & reproductive organs

>Circuitry of Sympathetic NS Divergence = each preganglionic cell synapses on many postganglionic cells Circuitry of Sympathetic NS Divergence = each preganglionic cell synapses on many postganglionic cells Mass activation due to divergence multiple target organs fight or flight response explained Adrenal gland modified cluster of postganglionic cell bodies that release epinephrine & norepinephrine into blood

>Anatomy of Parasympathetic NS Preganglionic cell bodies found in  4 cranial nerve nuclei Anatomy of Parasympathetic NS Preganglionic cell bodies found in 4 cranial nerve nuclei in brainstem S2 to S4 spinal cord Postganglionic cell bodies very near or in the wall of the target organ in a terminal ganglia

>Parasympathetic Cranial Nerves Oculomotor nerve ciliary ganglion in orbit ciliary muscle & pupillary constrictor Parasympathetic Cranial Nerves Oculomotor nerve ciliary ganglion in orbit ciliary muscle & pupillary constrictor muscle inside eyeball Facial nerve pterygopalatine and submandibular ganglions supply tears, salivary & nasal secretions Glossopharyngeal otic ganglion supplies parotid salivary gland Vagus nerve many brs supply heart, pulmonary and GI tract as far as the midpoint of the colon

>Parasympathetic Sacral Nerve Fibers Form pelvic splanchnic nerves  Preganglionic fibers end on terminal Parasympathetic Sacral Nerve Fibers Form pelvic splanchnic nerves Preganglionic fibers end on terminal ganglia in walls of target organs Innervate smooth muscle and glands in colon, ureters, bladder & reproductive organs

>ANS Neurotransmitters Classified as either cholinergic or adrenergic neurons based upon the neurotransmitter released ANS Neurotransmitters Classified as either cholinergic or adrenergic neurons based upon the neurotransmitter released Adrenergic Cholinergic

>Cholinergic Neurons and Receptors Cholinergic neurons release acetylcholine from  preganglionic neurons & from Cholinergic Neurons and Receptors Cholinergic neurons release acetylcholine from preganglionic neurons & from parasympathetic postganglionic neurons Excites or inhibits depending upon receptor type and organ involved Nicotinic receptors are found on dendrites & cell bodies of autonomic NS cells and at NMJ Muscarinic receptors are found on plasma membranes of all parasympathetic effectors

>Adrenergic Neurons and Receptors Adrenergic neurons release norepinephrine (NE)  from postganglionic sympathetic neurons Adrenergic Neurons and Receptors Adrenergic neurons release norepinephrine (NE) from postganglionic sympathetic neurons only Excites or inhibits organs depending on receptors Alpha1 and Beta1 receptors produce excitation Alpha2 and Beta2 receptors cause inhibition Beta3 receptors(brown fat) increase thermogenesis

>Adrenergic Neurons and Receptors NE lingers at the synapse until enzymatically inactivated by monoamine Adrenergic Neurons and Receptors NE lingers at the synapse until enzymatically inactivated by monoamine oxidase (MAO) or catechol-O-methyltransferase (COMT)

>Physiological Effects of the ANS Most body organs receive dual innervation innervation by both Physiological Effects of the ANS Most body organs receive dual innervation innervation by both sympathetic & parasympathetic Hypothalamus regulates balance (tone) between sympathetic and parasympathetic activity levels Some organs have only sympathetic innervation sweat glands, adrenal medulla, arrector pili mm & many blood vessels controlled by regulation of the “tone” of the sympathetic system

>Sympathetic Responses  Dominance by the sympathetic system is caused by physical or emotional Sympathetic Responses Dominance by the sympathetic system is caused by physical or emotional stress -- “E situations” emergency, embarrassment, excitement, exercise Alarm reaction = flight or fight response dilation of pupils increase of heart rate, force of contraction & BP decrease in blood flow to nonessential organs increase in blood flow to skeletal & cardiac muscle airways dilate & respiratory rate increases blood glucose level increase

>Sympathetic Responses  Long lasting due to lingering of NE in synaptic gap and Sympathetic Responses Long lasting due to lingering of NE in synaptic gap and release of norepinephrine by the adrenal gland

>Parasympathetic Responses Enhance “rest-and-digest” activities Mechanisms that help conserve and restore body energy during Parasympathetic Responses Enhance “rest-and-digest” activities Mechanisms that help conserve and restore body energy during times of rest Normally dominate over sympathetic impulses SLUDD type responses = salivation, lacrimation, urination, digestion & defecation and 3 “decreases”--- decreased HR, diameter of airways and diameter of pupil

>Parasympathetic Responses Paradoxical fear when there is no escape route or no way to Parasympathetic Responses Paradoxical fear when there is no escape route or no way to win causes massive activation of parasympathetic division loss of control over urination and defecation

>Regulation of the ANS: Without the regulatory activity of the ANS, an individual has Regulation of the ANS: Without the regulatory activity of the ANS, an individual has limited ability to maintain homeostasis and readily succumbs to sudden changes in environmental conditions.

>Controlling Factors: 1. Autonomic reflexes Example:  baroreceptors   located in arteries Controlling Factors: 1. Autonomic reflexes Example: baroreceptors located in arteries sensitive to pressure changes results in changes in heart rate

>Autonomic reflexes  These reflexes control most of the activity of visceral organs, glands, Autonomic reflexes These reflexes control most of the activity of visceral organs, glands, and blood vessels.

>Controlling Factors: 2. Cerebrum 3. Hypothalamus Controlling Factors: 2. Cerebrum 3. Hypothalamus

>Functional Generalizations about the ANS 1. Both divisions produce stimulatory and inhibitory effects. 2. Functional Generalizations about the ANS 1. Both divisions produce stimulatory and inhibitory effects. 2. Most organs are innervated by both divisions. 3. Usually each division produces an opposite effect on a given organ.

>Functional Generalizations about the ANS 4. Either division alone or both working together can Functional Generalizations about the ANS 4. Either division alone or both working together can coordinate the activities of different structures. 5. The sympathetic division produces more generalized effects than the parasympathetic division.

>Functional Generalizations about the ANS 6. Sympathetic activity generally prepares the body for physical Functional Generalizations about the ANS 6. Sympathetic activity generally prepares the body for physical activity. 7. Parasympathetic activity is more important for vegetative functions like sitting through an Anatomy and Physiology lecture.