Cellix Ltd Vivienne Williams CEO v williams cellixltd com

Cellix Ltd. Vivienne Williams, CEO v. williams@cellixltd. com SME & Academic Collaborations in H 2020 04 June 2015

Summary Cellix Overview • • • Spin-out from Trinity College Dublin Headquartered in Dublin, Ireland: • Research & development • Manufacturing facilities Cellix’s products are currently sold direct and through a network of international distributors Japan: IEDA USA: Cell Biolabs Japan: Shoshin Em France, Germany, Nordic, Benelux, Spain, Portugal, Italy: tebu-bio China: Qichi India: Marsap Austria: THP USA & worldwide: WPI Italy: Crisel Greece: DIS Singapore: Precision Tech China: Will. Tek China: Passkey Taiwan: Major Instruments

Cellix Products and expertise Experience in. . . • Microfluidic pumping solutions: patented syringe pumps with pulseless flow; pressure pumps; positive displacement; recirculation etc. • Microfluidic biochips with robust macro-to-micro connections; 2 D and 3 D designs; embedded membranes and electrodes; integration of sensors onchip; consideration of sample handling/mixing/dilution etc. • Development of cell-based assays . . . has placed us in a unique position to offer integration services to our customers.

Example OEM Projects: Commercial outputs from FP 7 Customer: Sector: Aim: ent’s Integrating Purpose: Multinational company, revenues of ~ € 115 M in 2013 Clinical diagnostics Develop next generation analyzers for POC market. format. Working with them on the development of the microfluidic liquid handling and sample handling automation for their next generation analyzers for POC market. Microfluidic liquid handling & protocol development: Sensor area integration on-chip: Tested in client’s existing analyzers for signal read-out (jig for chips 3 D printed for simple proof-of-concept tests) Deal type: Deal value: R&D contract with heads of terms on exclusive OEM supply agreement. Not disclosed

Example OEM Projects: Commercial outputs from FP 7 Customer: Aim: Multinational company, revenues of ~ € 65 M in 2013 Prototype simple, easy-to-use, robust device which may be used by low- Purpose: level technicians for sample processing. Integrating improved impedance spectroscopy methods on-chip to characterize small differences in cellular content. Integrated to perform specific assays for client Cellix’s patented pumps & impedance chips Deal type: Deal value: R&D contract with heads of terms on licensing agreement. R&D contract worth € 1 M

H 2020: Sniff. Phone Consortium: Co-ordinated by Hossam Haik at Technion University Israel; partners include Siemens. Aim: Smart Phone for Disease Detection from Exhaled Breath Value: € 5. 8 M Cellix’s Contribution: Development microfluidic production& & of pumps miniature integration.

Collaborating with SMEs – some advice • Don’t ask them because you need an SME involved – ask them because you need their expertise. We don’t want to be a “token” SME in a proposal. • Review the SME website but be aware that this may not reveal all. . . • Don’t expect the SME to write the proposal for you. • Approach them early – at least 3 months before the submission deadline. • Remember, SMEs are in business to make a profit – they will always look for the commercial output from a grant.

Thank you for your attention Vivienne Williams Cellix Limited Tel: +353 -1 -4500 -155 Email: v. williams@cellixltd. com 04 June 2015