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CEITEC at Masaryk University Name Position City, January 1 st 2012 CEITEC at Masaryk University Name Position City, January 1 st 2012

CEITEC at Masaryk University Ø Newly established research institute within Masaryk University Ø Part CEITEC at Masaryk University Ø Newly established research institute within Masaryk University Ø Part of CEITEC consortium – interdisciplinary research topics (6 partners) 2

CEITEC – Central European Institute of Technology 3 CEITEC – Central European Institute of Technology 3

CEITEC at Masaryk University - Mission CEITEC MU, as the leading member of CEITEC CEITEC at Masaryk University - Mission CEITEC MU, as the leading member of CEITEC consortium and a research institute within MU, aims to improve quality of life and human health through scientific research. 4

CEITEC at Masaryk University - Vision 2020 Ø Internationally recognized research institute in life CEITEC at Masaryk University - Vision 2020 Ø Internationally recognized research institute in life sciences with strong links to material science Ø One scientific community bridging disciplinary boundaries Ø Role model for a university research institute in Czech and Central European context Ø Source of inspiration and innovation to the university, a driver of internationalization of the university Ø An institute with open, international, fair and friendly environment 5

CEITEC at MU - Strategic Priorities Ø Strong institutional profile Ø Leadership in science CEITEC at MU - Strategic Priorities Ø Strong institutional profile Ø Leadership in science Ø Excellent working environment Ø Sustainable and efficient institute with good governance Ø Strong community open to its environment 6

CEITEC at Masaryk University Ø Ø International Ph. D programme Ø State of the CEITEC at Masaryk University Ø Ø International Ph. D programme Ø State of the art infrastructure – 8 core facilities as a part of national and international infrastructures Ø 7 International environment ISAB – International Scientific Advisory Board

CEITEC at Masaryk University 35 Research Groups 270 Researchers (FTE) 9 Core Facilities Ø CEITEC at Masaryk University 35 Research Groups 270 Researchers (FTE) 9 Core Facilities Ø Since 2010 / fully operational from 2014 Ø 21, 1 mio EUR Total Budget (2016) 8

CEITEC at Masaryk University 9 CEITEC at Masaryk University 9

CEITEC at Masaryk University 2015 Ø Ø 10 Research Groups Core Facilities 2016 41 CEITEC at Masaryk University 2015 Ø Ø 10 Research Groups Core Facilities 2016 41 35 8 9

CEITEC at Masaryk University – Scientifiic Staff FTE 2015 - 306 2016 - 270 CEITEC at Masaryk University – Scientifiic Staff FTE 2015 - 306 2016 - 270 HC 2015 - 356 2016 - 328 11

CEITEC at Masaryk University - Core Facilities MRI Resolution 0. 25 mm Cryo-EM NMR CEITEC at Masaryk University - Core Facilities MRI Resolution 0. 25 mm Cryo-EM NMR High resolution Solid and Solution Complex structures state Research infrastructures (Czech Road map) 2015 -2020 5 projects recommended for funding 2016 -2022, 4 infrastructures bound to ESFRI 12 X-ray diffraction Crystal state

CEITEC at MU - Scientific Publications 2011 - 2015 All CEITEC MU publications 2015 CEITEC at MU - Scientific Publications 2011 - 2015 All CEITEC MU publications 2015 - Blood (2 x), Embo Journal (1 x), Leukemia (4 x) Plant Cell (1 x), Chemical Scince (3 x), Nucleic Acid Research (8 x)….

CEITEC at Masaryk University - Funding Prestigious and strategic projects ERC Grants EMBO Installation CEITEC at Masaryk University - Funding Prestigious and strategic projects ERC Grants EMBO Installation Grants Pavel Plevka (2013) FP 7 -ERC-St. G – Pico. Structure Richard Štefl (2015) H 2020 -ERC-Co. G – DECOR Lukáš Trantírek (2012) Karel Říha (2013) Pavel Plevka (2014) Peter Lukavsky (2014) ERA Chair (FP 7 -Widening Participation) 2014 -2018 The ERA Chair Culture as a Catalyst to Maximize the Potential of CEITEC budget 2, 246 M EUR ERA Chair Mary O´Connell TWINNING - H 2020 - Spreading Excellence and Widening Participation 3 projects – MEDGENET, TWINFUSYON, BISON (2016 – 2018) budget € 639 244; € 399 719; € 698 688 LIBRA - H 2020 - GERI-4 -2014 Unifying innovative efforts of European research centres to achieve gender equality in academia. budget € 133 750 14

International Network – Publications (139) EUROPE NORTH AMERICA Germany, 41/ Austria, 23/ England, 17/ International Network – Publications (139) EUROPE NORTH AMERICA Germany, 41/ Austria, 23/ England, 17/ Italy, 15/ France, 15/ Slovakia, 10/ Switzerland, 9/ Netherlands, 9/ Sweden, 8/ Belgium, 8/ Spain, 7/ Greece, 7/ Poland, 6/ Denmark, 5/ Turkey, 3/ Russia 3/ Norway, 3/ Wales, 2/ Ukraine, 2/ Scotland, 2/ Slovenia, 1/ Romania, 1/ Liechtenstein, 1/ Iceland, 1/ Croatia, 1/ (31) USA, 29/ Canada, 2/ AFRICA (24) ASIA Peoples R China, 6/ Japan, 5/ India, 5/ South Korea, 2/ Iran, 2/ Singapore, 2/ Israel, 1 / Malaysia, 1/ (1) Egypt SOUTH AMERICA (4) Brazil, 3/ Argentina, 1/ OCEANIA (3) Australia 3/ Numbers show the volume of publications arisen within collaboration between CEITEC MU and research groups from the other 15 . countries and continents 15/celkem

CEITEC - EU Life Strategic Partnership EU-LIFE mission is to foster excellence, share knowledge, CEITEC - EU Life Strategic Partnership EU-LIFE mission is to foster excellence, share knowledge, and influence research policy in life sciences. 16

CEITEC at MU - Research Focus Research Centre: Molecular Medicine Core facility: Genomics Ø CEITEC at MU - Research Focus Research Centre: Molecular Medicine Core facility: Genomics Ø Ø 17 Targeted therapies and personalized medicine – oncological, hematological and immunological diseases. Testing new drugs and diagnostic kits mainly for leukemias and lymphomas. Well characterized cohorts of oncological and hematological patient samples. Accredited Core Facility (ISO 15189) – massively parallel (Next Generation) sequencing, DNA microarrays, capillary sequencing and real-time q. PCR.

Research Focus Ø Research Group: Microenvironment of immune cells Molecular pathways that regulate microenvironmental Research Focus Ø Research Group: Microenvironment of immune cells Molecular pathways that regulate microenvironmental interactions in normal and malignant immune cells Ø Research Group: Molecular Oncology II – Solid Cancer Colorectal cancer (CRC), significance of nc. RNAs in its pathogenesis, and potential utilization of nc. RNAs as biomarkers or even therapeutic targets Ø Research Group: Structural Virology Structural understanding of virus life-cycles and using this knowledge to develop anti-viral therapies. Using X-ray crystallography, Cryo-electron microscopy and Cryo-electron tomography. 18

Research Focus Ø Research Group: Structure of Biosystems and Molecular Materials Smart metallodrug-carrier systems Research Focus Ø Research Group: Structure of Biosystems and Molecular Materials Smart metallodrug-carrier systems for delivery and targeting: The knowledge of in silico design is used to develop new metallodrugs with optimized binding to macrocyclic cavitands employed as drug carriers. Ø Research Group: Molecular Oncology II – Solid Cancer Novel techniques for separation and analysis of nucleic acids, proteins, small bio active molecules & drugs based on electrophoretic and microfluidic systems, electrochemical and optical methods, and nanotechnologies. 19

Thank you for your attention Central European Institute of Technology Masaryk University Kamenice 753/5 Thank you for your attention Central European Institute of Technology Masaryk University Kamenice 753/5 625 00 Brno, Czech Republic www. ceitec. muni. cz | [email protected] muni. cz