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CD 11 c+ Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD 4+ T-Cell CD 11 c+ Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD 4+ T-Cell Priming Efficacy Under Hypercholesterolemic Conditions Associated With Atherosclerosis by René R. S. Packard, Elena Maganto-García, Israel Gotsman, Ira Tabas, Peter Libby, and Andrew H. Lichtman Circulation Research Volume 103(9): 965 -973 October 24, 2008 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. CD 11 c+ cells accumulate lipids within atherosclerotic plaques and when exposed Figure 1. CD 11 c+ cells accumulate lipids within atherosclerotic plaques and when exposed to cholesterol in vitro. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. DCs conserve T-cell stimulation efficacy when exposed to cholesterol in vitro. René Figure 2. DCs conserve T-cell stimulation efficacy when exposed to cholesterol in vitro. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.

Figure 3. Systemic inflammatory response and DC lipid accumulation in vivo during hypercholesterolemia. René Figure 3. Systemic inflammatory response and DC lipid accumulation in vivo during hypercholesterolemia. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.

Figure 4. DCs maintain T-cell priming potency in vivo during hypercholesterolemia. René R. S. Figure 4. DCs maintain T-cell priming potency in vivo during hypercholesterolemia. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.

Figure 5. DCs conserve complete antigen-processing and T-cell priming capabilities within lymph nodes under Figure 5. DCs conserve complete antigen-processing and T-cell priming capabilities within lymph nodes under in vivo hypercholesterolemia. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.

Figure 6. Preserved DC machinery involved in antigen processing and T-cell stimulation during hypercholesterolemia Figure 6. Preserved DC machinery involved in antigen processing and T-cell stimulation during hypercholesterolemia in vivo. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.

Figure 7. Preserved CD 4+ T-cell priming in vivo under dyslipidemic conditions. René R. Figure 7. Preserved CD 4+ T-cell priming in vivo under dyslipidemic conditions. René R. S. Packard et al. Circ Res. 2008; 103: 965 -973 Copyright © American Heart Association, Inc. All rights reserved.