Скачать презентацию CBTTC Expansion in China through BGI CNBC Charles Bao Скачать презентацию CBTTC Expansion in China through BGI CNBC Charles Bao

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CBTTC Expansion in China through BGI/CNBC Charles Bao, Ph. D General Manager BGI Americas CBTTC Expansion in China through BGI/CNBC Charles Bao, Ph. D General Manager BGI Americas Corporation 2017 CBTTC Annual Investigator Meeting May 8 th, 2017 © 2017 BGI

BGI Introduction • Established in 1999 with participation in the Human Genome Project • BGI Introduction • Established in 1999 with participation in the Human Genome Project • World’s largest genomic organization, experienced in genomic research, commercial NGS services, diagnostics, and sequencer manufacturing 2 © 2017 BGI

BGI Quick Facts 3 © 2017 BGI 3 BGI Quick Facts 3 © 2017 BGI 3

China National Gene Bank (CNGB Overview) • • Non-profit organization Public Private Partnership (PPP) China National Gene Bank (CNGB Overview) • • Non-profit organization Public Private Partnership (PPP) Jointed funded by State Government, Shenzhen Municipal government and BGI Operated by BGI Research Missions: • • 4 To act as a platform for integrating genetic resources and capabilities To lead the innovation, exploration and testing of new genomics technologies To support the development of the life sciences and bio-economy in China To maintain international competitiveness and influence in global genomics community © 2017 BGI

Platform and Infrastructure Sequencing Platform Synthesis and Editing Platform (reading) Biorepository (sample repository) Global Platform and Infrastructure Sequencing Platform Synthesis and Editing Platform (reading) Biorepository (sample repository) Global collaborations (writing) Database (data repository) Living biobank (living species repository) Collaborations over the platforms 5 © 2017 BGI 5

CNGB - Biorepository Automatic sample storage system with more than 10 million samples Animal CNGB - Biorepository Automatic sample storage system with more than 10 million samples Animal and plant genetic resources 386, 000 Microbial resources 36, 000 Plant germplasm resources (millet etc. ) 5, 000 Chinese unique genetic resources and sample database of millet • Collected 2, 540 millet samples • Sequenced 2, 489 samples with 380 Gb data • Opened samples and data to cooperative breeding institutions The world’s largest repository of human enteric bacteria • Selected 17, 000 bacterial strains • Sequenced 2, 300 strain samples with 11. 5 Gb data • Discovered 100+ new species Genomics: Deciphering the gut flora Was named by Nature as “One of the top tem advancements in science and technology in the world” 6 © 2017 BGI 6

CNGB - Sequencing Platform BGISEQ-500 The BGI Desktop Sequencer with accuracy, flexibility, speed, simplicity CNGB - Sequencing Platform BGISEQ-500 The BGI Desktop Sequencer with accuracy, flexibility, speed, simplicity and expandability 7 © 2017 BGI Sequencing capacity 150 BGISEQ-500 sequencers, with data output of ~5 PB per year

BGISEQ-500 Sequencing Applications BGISEQ-500 PE 100 Demo Data Transcriptome: http: //www. ebi. ac. uk/ena/data/view/PRJEB BGISEQ-500 Sequencing Applications BGISEQ-500 PE 100 Demo Data Transcriptome: http: //www. ebi. ac. uk/ena/data/view/PRJEB 19428 Sample: UHRR(Universal Human Reference RNA) Whole Exome: http: //www. ebi. ac. uk/ena/data/view/PRJEB 19426 Sample: (Genome in a Bottle) Human DNA- NA 12878 Whole Genome: http: //www. ebi. ac. uk/ena/data/view/PRJEB 19427 Sample: (Genome in a Bottle) Human DNA- NA 12878 8 © 2017 BGI

CNGB - Data Repository and Analysis Bio-informatics Data Center • 46 open database • CNGB - Data Repository and Analysis Bio-informatics Data Center • 46 open database • 118 million page views Highly efficient network Cloud storage Cloud computing Aim to establish world’s first multi-omics cloud platform 9 © 2017 BGI

BGI-Online Cloud Solution 10 © 2017 BGI BGI-Online Cloud Solution 10 © 2017 BGI

BGI Online Demo Case for Speed Analysis Benchmark: 1000 WES with 100 X Analysis BGI Online Demo Case for Speed Analysis Benchmark: 1000 WES with 100 X Analysis completed within 24 hours Start End 21 h 47 min 12 sec Autism Spectrum Disorder Project: 100 WGS with 30 X Analysis completed within 17 hours 11 © 2017 BGI

Overview of Beijing Tiantan Hospital • Founded in 1956, affiliated with Capital Medical University Overview of Beijing Tiantan Hospital • Founded in 1956, affiliated with Capital Medical University • A large first-class general hospital with neurosurgery specialty • Patient visits steadily increased tallying up to over 1, 000 outpatient visits and 30, 000 inpatient admissions per year • Founded by Dr. Zhongcheng Wang, Neurosurgery Center of Tiantan • Hospital has been recognized as the largest neurosurgical base in the world 12 © 2017 BGI

Neurosurgical Center • Pediatrics • Brain trauma • Spinal cord & column • Supratentorial Neurosurgical Center • Pediatrics • Brain trauma • Spinal cord & column • Supratentorial tumours • Cerebrovascular disease • Pituitary adenoma and subtentorial tumors • Skull base and brain stem tumours • Endoscopy and functional disease • Intracranial diseases associated with ENT • Glioma center • Ward for officials and VIP 13 © 2017 BGI

Neurosurgical Center Over 12, 000 operations in 2015, tumor 7569; Vascular diseases 1472; Functional Neurosurgical Center Over 12, 000 operations in 2015, tumor 7569; Vascular diseases 1472; Functional neurosurgery 940; Brain trauma 1, 025; Others 834 15 Subdivisons 14 © 2017 BGI 170 Neurosurgeons: • 55 full-time senior professors • 50 associate professors • 65 attending and residences 420 Beds

1 Pediatric Neurosurgery 15 © 2017 BGI 1 Pediatric Neurosurgery 15 © 2017 BGI

CNGB – CBTTC collboration More Chinese hospital partners Sample collection and biobanking 16 © CNGB – CBTTC collboration More Chinese hospital partners Sample collection and biobanking 16 © 2017 BGI Data generation and analysis Data integration via BGI-Online Hospital enrollment and coordination Joint Education

Collaboration Outcome • CBTTC global network expansion into China • CBTTC diagnosis and treatment Collaboration Outcome • CBTTC global network expansion into China • CBTTC diagnosis and treatment standard available to chinese pediatric brain tumor patients • Increased volume of data and clinical case from china expedites genetic discovery at CBTTC • Enrich CNGB biorepository and database resource 17 © 2017 BGI