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BSE: World Situation and USDA Response FDA TSE Advisory Committee Silver Spring, MD October BSE: World Situation and USDA Response FDA TSE Advisory Committee Silver Spring, MD October 14, 2004 Lisa A. Ferguson, DVM Senior Staff Veterinarian USDA, APHIS, Veterinary Services

Total BSE cases worldwide n Cumulative total – greater than 188, 900 cases n Total BSE cases worldwide n Cumulative total – greater than 188, 900 cases n Greater than 96% in United Kingdom n OIE website lists current reported totals: n www. oie. int

Total BSE cases worldwide Austria Belgium 1 126 Japan 13 Liecht. 2 Canada 2 Total BSE cases worldwide Austria Belgium 1 126 Japan 13 Liecht. 2 Canada 2 Luxemb. 2 Czech 14 Denmark 13 Netherl. 76 Poland 18 Finland 1 France 926 Germany 335 Portugal 914 Slovakia 18 Slovenia 5 Greece 1 Ireland 1441 Spain 479 1 Switz. 454 Israel Italy 115 Total non. UK UK 4957 183, 972

EU summary n BSE testing in 2003 (EU 15) Total of 10 million cattle EU summary n BSE testing in 2003 (EU 15) Total of 10 million cattle tested (8. 7 million healthy) n 1, 364 positive n Number of BSE cases and overall prevalence decreased by approximately 35% compared to 2002 n Demonstrate control measures are having some effect n

Prevalence: Cases per million adult cattle Adult Positives Prevalence cattle (mil) 2003 2002 Total Prevalence: Cases per million adult cattle Adult Positives Prevalence cattle (mil) 2003 2002 Total EU 38. 9 1364 35 53 15 Spain 3. 5 173 49 39 France 10. 8 13 22 Ireland 3. 2 185 57 103 Portugal 0. 7 133 170 107 UK 4. 9 614 125 230

Assessments of country status n Geographical BSE-risk n n EC requested re-assessments, due to Assessments of country status n Geographical BSE-risk n n EC requested re-assessments, due to additional findings of BSE n n n Initial assessments completed in 2000 by SSC Level I-IV US considered Level II in 2000 US, Canada, Mexico, South Africa – Level III Australia – remains Level I OIE recognition of “provisionally free” n Argentina, Iceland, Singapore, Uruguay

USDA-APHIS Import Regulations Title 9 Code of Federal Regulations, Parts 93 -98 n Part USDA-APHIS Import Regulations Title 9 Code of Federal Regulations, Parts 93 -98 n Part 94. 18 – list of countries affected with BSE or that present an undue risk of BSE n November 2003 – proposed rule: n Create minimal risk category n Import conditions for certain animals and products from minimal risk regions n Place Canada in minimal risk category n n Reviewing and analyzing comments

Canadian situation n 2 indigenous cases identified n n n May 2003 – beef Canadian situation n 2 indigenous cases identified n n n May 2003 – beef cow in Alberta December 2003 – dairy cow in Washington Extensive epi investigations SRM removal – June 2003 Feed ban in place since 1997 - considering additional animal feed restrictions Increased surveillance – targeted high-risk n n Goal – 8, 000 in 2004 - >6300 samples to date Goal – 30, 000 in 2005

FSIS Actions n n n Federal Register - Jan 12, 2004 Prohibit non-ambulatory disabled FSIS Actions n n n Federal Register - Jan 12, 2004 Prohibit non-ambulatory disabled cattle from slaughter for human consumption SRMs prohibited from human food n n n Tonsils, small intestine of cattle of all ages; brain, spinal cord, eyes, dorsal root ganglia, trigeminal ganglia of cattle >30 months Mechanically separated meat prohibited from human food; process controls on AMR Carcass of animals sampled not passed for inspection until negative test results received

BSE National Surveillance Plan GOAL: Obtain as many samples as possible from the targeted BSE National Surveillance Plan GOAL: Obtain as many samples as possible from the targeted high-risk population in a 12 -18 month period

BSE Surveillance Plan Targeting population where disease is most likely to be diagnosed – BSE Surveillance Plan Targeting population where disease is most likely to be diagnosed – most efficient n Assumption if we cannot find disease in targeted – or most likely – population, even more unlikely to be found in non-targeted population n Use data obtained to extrapolate information about broader cattle population n

BSE – Targeted Surveillance n n n Non-ambulatory animals Dead stock Field CNS Cases BSE – Targeted Surveillance n n n Non-ambulatory animals Dead stock Field CNS Cases and on-farm suspects Veterinary Diagnostic Laboratory data Public health laboratories Ante-mortem condemns at slaughter

BSE Surveillance – May 1990 – FY 2004 (thru 5/31/2004) 20, 543 19, 990 BSE Surveillance – May 1990 – FY 2004 (thru 5/31/2004) 20, 543 19, 990 17, 121 72 52 1 130 2 80 10 13 268 27 4 43 11 74 2 69 6 73 1 25 5 17 40

Surveillance: NVSL Bovine Brain Submissions FY 93 -04 (through 5/31/04) Surveillance: NVSL Bovine Brain Submissions FY 93 -04 (through 5/31/04)

Enhanced BSE Surveillance Total – ELISA and IHC tests conducted since June 1, 2004 Enhanced BSE Surveillance Total – ELISA and IHC tests conducted since June 1, 2004 – through October 10 n All negative results (2 inconclusives) n 81, 349 (79, 766 ELISA and 1, 583 IHC)

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