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“bringing the best of nature to mankind” • Our Facilities • Product Development • Making ACTIValoe® • Topical Indications • Qmatrix Processing • Certification • Innovation • Services Modified Aloe barbadensis Polysaccharide with Immunoregulatory Activity. Zhihua Qiu, Ken Jones: Planta Medica 66, 1 -5, 2000
The Farm at Aloecorp de Mexico Gonzales, Mexico (120 km from Tampico) Finishing & Packaging Facility Lyford, Texas ü Aloecorp is a Vertically Integrated Aloe vera supplier Processing • Processing capacity tripled since 2000 • Progressive Research Investment • Patented processing methods • Product & Process Innovation An ECONET Family Company
Time, Temperature & Sanitation üTTS Quality Control takes into account all aspects of growing, harvesting and processing Aloe vera raw materials to retain biological activity in the finished product. Time • Minimal time from Harvest to Stabilization • Minimal time of Processing • Minimal Heat exposure Temperature • HTST pasteurization followed by cold storage Sanitation • Quality Assurance and Control on production floor • In-process QC at every step
The Patented MAP Process ü Bioactivity Guided Process Development Unigen Pharmaceuticals investigated the biological role of polysaccharide molecular weight in order to develop a processing method that would retain and enhance the biological activity of native aloe… resulting in the patented processing method now used exclusively by Aloecorp. U. S. Patent 6, 436, 679 Our Patented Aloe vera Processing • Activates macrophage • Restores the UVB suppressed immune system • Stimulates fibroblast proliferation Publication Modified Aloe barbadensis Polysaccharide with Immunoregulatory Activity. Zhihua Qiu, Ken Jones: Planta Medica 66, 1 -5, 2000
The Patented MAP Process ü Further studies on MAP bioactivity Abstract conclusion Aloe polysaccharides of 5 – 400 k. Da exhibit • Most potent macrophage activation • Most phagocytic activity • Most potent antitumor activity in vivo G 2 E 1 – Aloe vera crude methanol extract G 2 E 1 D – Protein free MAP* G 2 E 1 DS 1 – Polysaccharide fraction < 5 k. Da G 2 E 1 DS 2 – Polysaccharide fraction 5 k. Da – 400 k. Da (MAP**) G 2 E 1 DS 3 – Polysaccharide fraction > 400 k. Da Publication Identification of Optimal Molecular Size of Modified Aloe Polysaccharides with Maximum Immunomodulatory Activity. Sun-A Im et al. : International Immunopharmacology 5, 2005 * MAP contains <5 k. Da - > 2000 k. Da PS with 3 X increase in max active PS fraction ** 1999 MAP paper identified a specific PS MW max activity of 80 k. Da. 2005 paper did not determine specific MW max.
The Patented MAP Process ü Bioactivity Guided Process Development q It has been noted that diverse results are reported in clinical studies using Aloe vera. This may be explained in part by the observation that researchers commonly do not determine the composition of aloe used in studies and, in particular, the content or molecular weight distribution of acetylated mannan polysaccharides. q Aloecorp is unique in this respect. Researchers using Aloecorp products are provided with extensive analytical characterization of the test material. As a result, consistent results have been published by these researchers. q Most importantly, all Aloecorp products are manufactured by our patented processing method based on the results of our bioactivity guided processing research. The polysaccharide content and molecular weight distribution of every batch of aloe produced by Aloecorp is determined by HPLC size exclusion chromatography
The Patented MAP Process ü Aloecorp’s patented processing method • Increases important MW fraction 3 X • Stabilized by HTST inactivation • Guaranteed PS content • Substantiated bioactivity monosaccharide cellulase In vivo topical application Modified Aloe Polysaccharide (MAP) 50 – 200 k. D Timed inactivation of cellulase
The Patented MAP Process Global Research ü Original research of Aloecorp’s Aloe vera products • Antigenotoxic Activity Carcinogenesis 1997 • Anticarcinogenic Activity Carcinogenesis 1999 • Stimulates Antioxidant Production Journal of Nutritional Science & Vitaminology. 2003 Aug • Lowers Cholesterol Journal of Nutritional Science & Vitaminology. 2003 Aug • Stimulates Immune System Planta Medica 1999 • Accelerates Wound Healing Planta Medica 1999 • Aloecorp MAP Enhances Native Biological Activity of Aloe International Immunopharmacology 2005
Topical Indications
Topical Indications q Biologically Active Vehicle in Topical Applications Journal of the American Podiatric Medical Association June 1989 q Accelerating Wound Healing British Journal of Dermatology 2001 Journal of the Medical Association of Thailand 2000 Journal of Ethnopharmacology 1998 Journal of the American Podiatric Medical Association 1994 Journal of Dermatologic Surgery and Oncology * Too many to list q Wound Healing/Dermal Integument (Anti-aging) Life Sciences 2003 Journal of Ethnopharmacology 1998 Molecular & Cellular Biochemistry 1998 Indian Journal of Experimental Biology 1998 Journal of the American Podiatric Medical Association 1994 Journal of the American Podiatric Medical Association 1989
Topical Indications q Moisturizing Effect Skin Research and Technology 2006 Association for Professionals in Infection Control and Epidemiology 2003 q Topical Immunomodulatory Activity International Immunopharmacology 2005 Planta Medica 1999 The Journal for Investigative Dermatology 1998 Planta Medica 1989 * Too many to list q Topical Anti-Inflammatory Korean Journal of Dermatology 2004 Journal of Ethnopharmacology 1996 Journal of the American Podiatric Medical Association 1989 Journal of the American Podiatric Medical Association 1994 *Too many to list
Topical Indications q Calcium and the Skin Calcium plays a critical roll in epidermal cell differentiation, turnover and wound healing. There is some evidence that cell turnover can be up-regulated by increasing calcium availability topically. Calcium has also been shown effective in treating dry skin due to its role in regulating lipid barrier processes. The National Cancer Research Institute has reported that people with low skin calcium experience greater premature aging of the skin and incidence of skin cancer. Aloe contains approximately 7% calcium by dry weight and this content is thought to play a role in the accelerated wound healing properties of aloe, moisturizing effect and anti-carcinogenic effects. For this reason aloe should be a critical component of cosmetic and cosmeceutical applications such as: • Stimulation of post-dermabrasion wound healing J Dermatol Surg Oncol 1990 • OTC exfoliation products (wound healing and moisturizing) • Anti-aging and skin cancer protection
Qmatrix TM Processing Another Innovation… Only from Aloecorp ü Aloecorp’s new Qmatrix™ Processing is the latest step in our effort to “bring the best of nature to mankind”. • Qmatrix™ is an patented aloe manufacturing process • A combination of our patented Modified Aloe Polysaccharide (MAP) process and patent pending Low Temperature/Short Time (LTST) drying process. • Qmatrix™ Processing… Designed to produce the highest quality Aloe vera powder available • Only from Aloecorp
Qmatrix TM Processing Another Innovation… Only from Aloecorp ü Published studies show that LTST dehydration technology provides superior retention of heat labile components, color & flavor characteristics • Gentle low temperature/short time drying • Superior sensory attributes retained (Academic study) • Superior retention of nutrients and bioactivity (Academic study) • Atmospheric pressure (no vacuum) • Energy efficient (Green) • Environmentally friendly (Green) • Superior solubility characteristics • New proprietary products due to versatility
Qmatrix TM Processing ü Solubility, bulk density and moisture absorbance are positively affected ü Dispersion & dissolution improved ü Bulk density optimized for application Minutes stirring Agitation Low Agitation moderate SD-80 19 8 QM-80 4. 5 3. 3 QM-10 1 1 ü Moisture absorbance rate reduced
ü Qmatrix™ Processing Product Advances (8010 XQ) Superior Quality Characteristics Superior Physical Characteristics v Sensory attributes (better taste and color) v Improved solubility v Color stability (after reconstitution) v Targeted bulk density v Shelf life (testing in process) v Improved flow ability v Reduced thermal degradation v Less hydroscopic v Reduced microbial degradation v Homogeneous dry matrix
New From Aloecorp ü Proprietary blends and Turn-key products possible v Patent submitted November 2004 Attorney Docket: ALOE. 01/PR Express Mail No. : DEHYDRATION OF FOOD COMBINATIONS FIELD of the invention The invention relates to the drying of blends of aloe, foods or food extracts, herbs or herb extracts, supplements, and the like.
New From Aloecorp Qmatrix™ - O 2 P™ Aloe vera oil powders ü Qmatrix – O 2 P Processing enables aloe & oil mixtures to be dried as stable, unique powders Concept • Combinations of nutritional, functional and therapeutic foods, herbs and excipients are combined with aloe to produce proprietary products • Liquid combinations dried by this process are stabilized in a homogeneous dry matrix • Patented oil to powder conversion process • Turn-key proprietary products can be developed • Offers an alternative tablet or capsule delivery form • Transforms most edible oils, pastes, gels, liquids into a free-flowing powder
New From Aloecorp Qmatrix™ - O 2 P™ Aloe vera oil powders ü Multiple Applications • Nutraceuticals • Food fortification • Cosmetics, personal care • Animal feed, pet food fortification
Certified Products ü Aloecorp products are Certified for the Quality and Purity you need IASC • Aloecorp products first Certified in 1989 • Currently have 26 IASC Certified products ISO 9001 • ISO Certified since 2003 Organic • Powder products certified Organic in Texas and Europe Kosher • Certified Kosher since 1999 Halal (2005) v Aloecorp expects to be c. GMP by 2007
SA QA&C Scientific Affairs ü Innovative & service oriented… we are always working to provide our customers with the best product and support Scientific Affairs • Original research • Technical consultation • Indications library • Quality Assurance • Quality Control • Analytical labs • International support structure • Europe, Asia, Mexico, USA
Vertically Integrated The World’s Leading Supplier of Quality Aloe vera Summary • Leading the Industry in Quality & Scientific advances • Bioactivity guided process development • Original research on the product we supply • Investment and innovation • Certified products • Commitment to product development • Scientific support and services
ALOECORP “bringing the best of nature to mankind” Thank You CEO Peter Hafermann Chief Science Officer Ken Jones Director of Business Development Barb Apps VP Sales and Marketing Wayne Mc. Cune VP International Sales Mick Anderson Sales Jeff Barrie Bob Smith
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