BIOCHEMISTRY OF EXTRACELLULAR MATRIX
Collagen structure
Proline and lysine residues 4 -hydroxyproline, 5 -hydroxylysine residues
Collagen synthesis
The formation of crosslinks
Scurvy
Collagen. IV
Elastin
Elongation and consriction of elasti
Specific products of enzymatic hydrolysis of elastin Desmosine
Fibronectin disulphide bonds С-terminal end
Transglutaminase
Laminin
Nidogen (Entactin) binding site of collagen and proteoglycans binding site of laminin
Glycosaminoglycans hyaluronic acid
Aggrecan, combined with hyaluronic acid 1 — chains of chondroitin sulphate 2 — chains of keratan sulphate 3 — polypeptide chain HA — hyaluronic acid
Integrin structure
Extracellular matrix
Hydrolysis of collagen by collagenases
Dermatomyositis
Pulmonary fibrosis
Mucopolysaccharidosis
Osteogenesis imperfecta
BIOCHEMISTRY OF NERVOUS TISSUE
Blood Brain Barrier
Chemical composition Lipids Pyrimidines Phospholipids Glycolipids RNA Sphingolipids Purines Cholesterol
Carbohydrate metabolism
GABA shunt 31
32
Cholinergic synapse 33
Adrenergic synapses Adrenalin Noradrenalin Dopamin 34
GABA
BIOCHEMISTRY OF MUSCLE TISSUE
37
Muscle proteins Sarcoplasmic proteins (35%) Øglycolytic enzymes Øenzymes of tissue respiration, oxidative phosphorylation, nitrogen and lipid metabolism Ømyoglobin Øparvalbumins
Muscle proteins Myofibrillar proteins (45%) ØMyosin ØActomyosin Øregulatory proteins (tropomyosin, troponin, α- and β-actinin). Stromal proteins (20%) ØCollagen ØElastin
The structure of the muscle fiber 40
Structure of myosin molecule 41
Actine structure 42
Structure of thin filament 43
Sources of energy for muscle work wor Creatine kinase mechanism Creatine phosphate + ADP Creatine + ATP Miokinase mechanism: 2 ADP = ATP + AMP Glycolytic mechanism (lactate, anaerobic) Aerobic ATP resynthesis mechanism (oxidative phosphorylation)
Mechanism of muscle contraction 45
46
47
48
Myopathy 49
50
Ischemic heart disease 51
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Connective, muscle, nervous tissues.ppt