Aventis Pharma 1 Aventis Pharma Prescription drugs

Aventis Pharma 1

Aventis Pharma Prescription drugs Aventis Pharma Vaccines Aventis Pasteur Therapeutic proteins Aventis Behring Diagnostics Dade Behring 2

Key Figures • 92, 500 employees – 80% in Pharma • 16 Bn€ Pharma sales – 5 th in top 10 • Strong & growing US presence with >35% sales • 19, 000 member sales force • 16. 8% R&D expenditure; 6500 scientists & technicians worldwide • 15% of R&D expenditure dedicated to alliances; about 50 major biotech collaborations; about 250 academic collaborations 3

Drug Innovation & Approval (R&D) Disease Groups supported by powerful technology platforms • ~6500 scientists & technicians worldwide Asian Drug Devt Ctr US Global and US Drug Devt Ctr - Immunology platform - Respiratory diseases - RA - CNS * Gene Therapy European Drug Devt Ctr FRANCE - Oncology, - Infectious Diseases - Neurodegenerative Diseases, (Parkinson & Alzheimer), JAPAN GERMANY -CV - Metabolic Diseases, - Osteoarthritis, Thrombosis 4

Drug Innovation & Approval in France CDG Airport SEINE ST DENIS HAUTS DE SEINE PARIS • Paris Research Centre • European Drug Devt Centre • ~2800 scientists & technicians Romainville Vitry-Alfortville Croix de Berny VAL DE MARNE ESSONNE 5 km Evry 5

New drug discovery technologies Preclinical Target Lead Candidate Ph. I / IIa Ph. IIb Ph. III Regulatory Selection. Identification Review Functional Genomics Technologies DNA chips Proteomics, cellular & animal models. . Lead Identification Technologies Med. Chem, Chem. Biol, Structural Genomics and Biology…. Technologies for Exploratory Development e. ADMET, TGX, PGX, Biomarkers…. Technologies for Global Rapid submissions Integrated Data and Knowledge Management e-submissions…. . 6

Metabolism Oncology CNS / ND Cardiovascular Rheumatoid Arthritis Osteoarthritis - DJD Respiratory Diseases Anti-Infectives Immunology platform Disease Biology Platforms Genomics Technology Platforms Aventis Genomics Centers Targets relevant to disease 7 External Collaborations & Networks Integration of Genomics Technologies & Disease Biology Platforms

Key Challenges • The post-human genome sequence race • • • functional genomics protein structure prediction re-thinking chemical approaches re-thinking clinical development • Continuous integration of technologies (alliances and partnering), information and knowledge (knowledge networks) • Availability of skilled work force (right skill-set and mind-set) 8

Post-doc Opportunities in Aventis Pharma, France In partnership with the European Commission: 12 Marie Curie Industry Host Fellowships for a 2 year period. • Parkinson’s Disease Gene Targets (3 positions) • Molecular Modeling and High Throughput Medicinal Chemistry (3 positions) • From Protein-Protein Interactions (yeast 2 H) to Lead Discovery Process (3 pos • Bio-Informatics in Toxicogenomics (1 position) • Cardiovascular Gene Therapy (1 position) • Adenoviral Vector-based system for Functional Genomics (1 position) Immediate Starting Date 9

Post-doc Opportunities in Aventis Pharma, France In partnership with the European Commission The position are open to members of the E. C. or resident of associated countries for more than 5 years. The age limit at the time of selection is 35 years old. Austria, Belgium, Bulgaria, Czech republic, Denmark, Estonia, Finland, Germany Greece, Hungary, Iceland, Ireland, Israel, Italy, Latvia, Liechtenstein Lithuania, Luxembourg, Netherlands, Norway, Poland, Portugal, Republic of Cyprus, Romania Slovakia, Slovenia, Sweden, Spain, United Kingdom However French citizens are ineligible as well as those who have been resident in France for more than 12 out of the last 24 months. 10

Post-doc Opportunities in Aventis Pharma, France Coming soon 9 post-doctoral positions • Statistics for Pharmacogenetics • Kinases in Oncology and Neurodegenerative diseas • Gene Transfer in Angiogenesis • Genomic Studies for the glial-neuronal interactions 11

Post-doc Opportunities in Aventis Pharma, France • Project Team • Networking • Publications/patents • Confidentiality • 250 KF/year (38 KEuros/yea • Social security included • 26 + 12 days holiday 12

Come and join us on the Aventis stand to learn more about our post-doctoral opportunities ! edith. heuillet@aventis. com 13