Auburn University MRI Research Center Facility Overview

Auburn University MRI Research Center

Facility Overview ● Three story – 45, 000 SF building ● MRI systems ■ ■ 3 Tesla (T) open-bore whole body 7 T whole body ● Designed to support research and clinical operations ■ Animal facilities Short-term holding facility Minimally-invasive procedures area ■ Training for faculty/staff/students ● Funded by a $21 M State bond issued in 2007

Auburn University Objectives ● Increase AU research funding ■ ■ ■ Establish AU as a leader in MRI research Enhance AU’s reputation as a major research university Attract businesses/industries to the AU Research Park ● Provide additional healthcare capabilities for the region

AU MRI Research Center ● Partnership between ■ ■ ■ Auburn University Siemens Healthcare East Alabama Medical Center Alabama Imaging Inc. University of Alabama at Birmingham (UAB) International Central South University (China) Siemens Corporate Technology (China)

Auburn Research Park

First Floor

Second Floor USAARL AU Research The Orthopaedic Clinic

Third Floor Rehab Works – EAMC AU Kinesiology Auburn Neurosurgery

Proposed Operating Scenario ● EAMC/AI controls 3 T and clinical area ■ ■ 8 hours/day (8 AM-4 PM) Mon-Fri Lease at market value ● AU controls 3 T ■ ■ 16 hours/day (4 PM-8 AM) Mon-Fri 24 hours/day Sat, Sun, holidays ● 7 T is research only ■ AU control 24/7

Timeline ● June ‘ 09 – Order equipment ● July ‘ 09 – Building design ● July ‘ 09 – Begin seminar series ● Jan ‘ 10 – Begin construction ● Summer ‘ 10 – Begin training ● Sept ‘ 10 – Construction complete ● Oct ‘ 10 – 3 T/7 T install ● Oct ‘ 10 – Begin 3 T operations ● Spring ‘ 11 – Begin 7 T operations

Current and Potential Research Projects ● Coil design & Manufacture ■ Technology commercialization Wireless technology ■ Auburn Athletics / Andrews Orthopedics ■ Autism Psychology / Human Sciences ■ ● Orthopedic Injury/Rehab ● f. MRI/Cognitive Neuroscience ■ ● Communication Disorders ■ Audiology Speech Pathology ■ UAB collaboration (NIH) ■ Diabetes and obesity ■ MRS/MRSI Alzheimer’s disease (NIH) ■ ● Advanced cardiac imaging ● Fat Imaging ● Metabolic/Molecular imaging ■

3 T Open-Bore MRI ● FDA certified for clinical use ● 70 cm bore ● 173 cm length

3 T Open-Bore MRI

Standard Applications ● Neurology ● Angiography ● Cardiac ● Body ● Oncology ● Orthopedic ● Pediactric ● Scientific

Spine Imaging at 3 T ● 4 -channel neck coil ● 24 -channel spine coil

Axially-Loaded Lumbar Spine MRI

Advanced Applications - DESS ● Increased cartilage/fluid contrast

Advanced Neuro Applications ● f. MRI acquisition/analysis ● Diffusion ● Perfusion ● BOLD Imaging ● Advanced Functional Neuro

In. Vivo Esys f. MRI System

7 T MRI

MAGNETOM UHF Community (22 sites): 1. Massachusetts General Hospital, Boston, USA n 2. Institute for Neuro-Biology, Magdeburg, Germany n 3. 5. 6. 7. 8. 9. 10. 11. Imaging since 02/2005 New York University, NYC, USA n 4. Imaging since 08/2002 Imaging since 03/2005 12. UPMC, Pittsburgh, USA n n former GE system converted to Siemens Imaging since 05/2007 13. Max Plank Institute, Leipzig, Germany n Imaging since 07/2007 Center for MR Research, Minneapolis, USA 14. Medical University of Vienna, Austria n Imaging since 04/2008 n Imaging with Siemens console since 12/2005 15. DKFZ, Heidelberg, Germany Gachon Medical School, Seoul, Korea n Imaging since 08/2008 n Imaging since 04/2006 16. Forschungszentrum Jülich, Germany (9. 4 T/900) Oregon Health, Portland, USA n Imaging since n First images 12/06 17. HUP, Philadelphia, PA, USA n Imaging since 06/2008 Erwin Hahn Institute for Magnetic Resonance, Essen, Germany 18. MDC, Berlin, Germany n Imaging since 09/2006 n Imaging since 12/2008 Center for Imaging in Biomedicine, Lausanne, Switzerland 19. CAS, Beijing, China n Imaging since 11/2006 n To be installed in Fall 2009 Max Plank Institute, Tübingen, Germany (9. 4 T) 20. Oxford University, Oxford, UK Imaging since 07/2007 n To be installed in spring 2010 CEA, Paris, France 21. Auburn University, Auburn, Alabama, USA n To be installed Fall 2010 Imaging since 02/2007 22. CMRR, Minneapolis, USA CEA, Paris, France, 11. 7 T n To be installed in fall 2010

Other Siemens 7 T Installations in USA ● MGH/ Harvard/ MIT ● NYU ● Penn ● Minnesota ● Portland, Oregon ● Pittsburgh

High-Field Imaging T 2 -weighted imaging of the human hippocampus 1. 5 T 7. 0 T

Functional MRI (f. MRI)

f. MRI at 1. 5 T, 3. 0 T, 7. 0 T Van der Zwaag, et al, Neuroimage. 2009 May 14

7. 0 T 1. 5 T Behr, et al, Skeletal Radiol. 2009 Sep; 38(9): 911 -7

Spatial Resolution 3 T 7 T f. MRI BOLD 3. 0 / 2. 5 mm 6 0. 5 / 3. 0 mm 3 Brain 0. 5 / 1. 0 mm 7 1. 0 / 1. 0 mm 7 0. 05 / 2. 0 mm 4 0. 7 / 0. 7 mm 5 Musculoskeletal 0. 30 / 2. 0 mm 2 0. 15 / 1. 0 mm 1 1. 2. 3. 4. 5. 6. 7. Regatte, et al, JMRI Vol. 25, 2 Pages: 262 -269 Kuhl, et al, Radiology. 2008 Apr; 247(1): 16 -35 Yacob, et al, Neuroimage. 2007 October 1; 37(4): 1161– 1177 Nakada, Brain and Development , 29 (6), July 2007, 325 -335 Thomas, et al, JMRI 2008 November; 28(5): 1266– 1272 Miller, et al, J Neurophysiol 99: 1969 -1982, 2008 Wiggins, et al, Magn Reson Med, 56(1), 216 -223, 2006

Spectroscopy ● Proton spectroscopy (3 T and 7 T) ■ ■ Single voxel Chemical shift imaging ● Multinuclear spectroscopy (7 T only) ■ 7 Li, 13 C, 17 O, 19 F, 23 Na, 31 P

MRI - Coils

Small Rodent MRI

Small Animal MRI

Fat Imaging

Fat Detection & Quantification

Thank You!