An intorduction to the Asian Bioinformation Center (ABC) Ueng-Cheng Yang Co-chair, ABC task force Vice-president, APBio. Net INCo. B 2009, Sept. 10, 2009 1
ABC is established in the personal genomics workshop on Apr. 4, 2009 Representatives from Australia, China, Japan, Korea, Singapore, Taiwan have signed the Seoul resolution in the past. 2
Motivation Hypothesis needs to be testable; prediction needs to be verified Bioinformatician needs to work closely with wet lab. researchers 3
The European experience • European molecular biology organization (EMBO) • European molecular biology laboratory (EMBL) • European molecular biology network (EMBNet) • European Bioinformatics Instittue (EBI) • Asia-Pacific International Molecular Biology Network (A-IMBN) • electronic International Molecular Biology Laboratory (e. IMBL) • APBio. Net • Virtual Asian Bioinformation Center (ABC) => ABI (? ) 4
Endorsement to the Seoul resolution is still open. 1. establishing a strategic plan for participating institutions and economies in Asia; 2. creating synergy that will make the Asian region stronger in bioinformation, bioinformatics and computational biology; … 6. aim to form Asian Bioinformation Centers throughout our region, and that will ultimately lead to the 5
Identify ABC’s uniqueness What’s the point of adding one more bioinformatics web site, which is not as resourceful as the major sites? 6
Good science needs … Reproducibility Verifiability 7
MIABi Minimal information about a bioinformatics investigation 8
To implement MIABi Author ID Data Repository 9
Author Id 1. Uniqueness of ID, deduplication and Synonymic/Multirole equivalence 2. Publisher/Editor/Reviewer/ Contributor/ Author Identity differentiation and disambiguation (not to be confused with other authors) 3. Prevention of identity theft (other person cannot claim credit for your work) 4. Non-repudiability (person cannot deny he didn't publish or make certain claims) 5. Accountability (person remains responsible for what he published, reviewer and claimed) 6. Traceabilty/Reachability (can find the person and track him down) 7. Security (no hacking, no unauthorised access, interception, cache poisoning) 8. Confidentiality of information (strong authentication - what you know, what you possess, what you are ; encryption) 9. Operational scaleability 10. Operational sustainabiity (business model) 11. Operationally high availability 12. Universal accessibility (pay or free) 13. Provenance (for audit trail) 14. Interoperability and 15. Standards Version control, change management and backward compatibility 16. Multilingual Support 17. Obsolescence management for individuals who change names, getting married or using aliases 18. Authentication and authority 19. Verification 10
Bio-mirror 2 will add data repository for the MIABi initiative 12 nodes: Australia Austria China Japan Korea Malaysia New Zealand Philippines Singapore Taiwan Thailand USA 11
Summary: project list of ABC • • Managed by ABC Task Force Formation of ABC Tech Comm Project 001 phase 1: Establish ABC website Project 001 Phase 2: Establish xx. abcenter. org in six countries, Australia (au), China (cn), Japan (jp), Korea (kr), Singapore (sg), Taiwan (tw) Draft for Minimal Information About Bioinformatics Investigation (MIABi) Author. ID registry system started in sg, ready for registration and replication throughout ABCs ABC Repository Initiative in preparation for Bio. Mirror 2 Research projects in negotiation – – Flu databases – AIDB Personal genome project Information security project Workflow integration across Asia 12
Events list of ABC • Apr. 3 -4: Personal genomics workshop in Seoul, Korea => Seoul resolution • July 23: APAN meeting in Kuala Lumpur and the 2 nd meeting, Malaysia => ABC technical meeting • Sept. 10: In. Co. B and the 3 rd ABC meeting in Singapore => Singapore resolution (? ) • Oct. 28: A-IMBN and the 4 th ABC meeting, ABC session in Penang, Malaysia => promote ABC resource to biologists • Mar. or Apr. : the 5 th ABC meeting in Taipei, Taiwan 13
Discussion The Singapore resolution 14
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