Amino acid and protein metabolism II
Metabolism of glycine, serine and threonine
Metabolism of sulfur amino acids Methionine + АТP S- adenosylmethionine + РРi + Рi
Metabolism of branched chain amino acids Leu, Ile, Val α-keto acids acyl-Co. A derivatives
Phenylalanin oxidation
Phenylketonuria
Tyrosine metabolism Tyrosine Dihydroxyphenyl alanine (DOPA)
Albinism
Catecholamines dopamine noradrenaline
Thyroid Hormones
Tyrosine metabolism Tyrosine Homogentisic acid Fumarate Acetoacetate
Homogentisuria
Tryptophan metabolism
Tryptophan metabolism
Iron
Transferrin
Ferritin
Heme
Hemoglobin verdoglobin (green pigment) - iron - globin biliverdin (bile pigment) Bilirubin
Bilirubin diglucuronide
Jaundice
Hemoglobin synthesis
Hemoglobin synthesis Succinyl. Co. A + Glycine 5 Aminolevul inic acid Protoporph yrin IX He + me Hemoglobin
Porphyria
NUCLEOPROTEIN AND NUCLEIC ACID METABOLISM
Purines catabolism adenine hypoxanthine guanine xanthine
Gout
Gout
Pyrimidines catabolism
Pyrimidine synthesis CO 2 + Glutamine + 2 ATP + H 2 O H 2 N CO OPO 3 H 2 + 2 ADP + H 3 PO 4 CP + Asp … orotydylic acid UMP + ATP UDP + ADP UDP + ATP UTP + ADP
Purine synthesis
Purine synthesis Inosine-5'-phosphate + Asp - fumarate + GTP - GDP, -Pi Adenosine-5'-phosphate Xantozin-5'-phosphate + Gln - Glu + ATP - AMP, -PP i Guanosine-5'-phosphate
d. GDF + ATP d. GTP + ADP
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Protein metabolism 2.ppt