Alchemist TM II Capacity reproducibility and efficiency of

Alchemist. TM II: Capacity, reproducibility and efficiency of an high-throughput crystallization screen preparation system. Craig Sterling Director of Business Development Rigaku

Automated Protein Crystallization Platform Phoenix RE Experimental Plate Setup Minstrel HT & Gallery 700 Incubators Imaging and Incubation Alchemist. TM II Screen Maker Integration Module Including Robotic Arm, plate and block storage, mixing station, piercing station, and foil and tape sealing Crystal. Trak. TM Information Flow & Management

Crystal. Mation. TM Features § Alchemist. TM II, Phoenix RE, Minstrel. TM HT imaging system and Gallery. TM 700 incubators operate independently or as part of the completely integrated Crystal. Mation system § Allows instruments to be added over time to meet budgets § Easy and seamless integration § Crystal. Trak. TM relational database application § Easy-to-use design is manageable by tech level personnel § Mixing, Piercing & Sealing accessories for Crystal. Mation. TM system § Low cost operation of $10 per plate including maintenance costs and chemical costs

Crystal. Trak. TM § Crystal. Trak seamlessly integrates the Rigaku Crystallization instruments, offering labs a complete end -to-end solution § Relational database tracks all of the necessary information used in crystallization trials such as chemicals, screens, protein samples, plate type information, images, and annotations § Crystal. Trak simplifies and aids in the crystallization process by providing tools that enable users to greatly improve crystallization trial productivity with less user intervention. § One-click optimization tools § Intuitive screen design tools § Crystal. Trak Web offers remote access to data

Custom Screen Maker – The Alchemist II § § § The best accuracy in the industry for handling stock solutions of all viscosities, dispensing volumes as low as 1µl using the Tapper. TM technology Produce liquid formulations without wasting chemicals during every cleaning, priming and wash cycle 74 Barcoded easy to swap reagents No tedious setup, cleaning and maintenance Dedicated syringe for each reagent Easy screen design with Crystal. Trak

NEW Seal-tight Bird. Feeders. TM § § § New threaded cap, Seal-tight design Long-term storage of stock solutions on deck Works with standard stock solution bottles Barcode Tracking of birdfeeders and stock solutions Autoclave-able design Easy-pour design for replacement of stocks Four different stock solution sizes 20 ml in Birdfeeder with cap Good for expensive stocks and additives 125 ml Nalgene bottles 250 ml Nalgene bottles Three Syringe sizes (Eppendorf) 100 ul 1 ml 10 ml § § § § §

Alchemist II

Automated Protein Crystallization Platform Phoenix RE Experimental Plate Setup Minstrel HT & Gallery 700 Incubators Imaging and Incubation Alchemist. TM II Screen Maker Integration Module Including Robotic Arm, plate and block storage, mixing station, piercing station, and foil and tape sealing Crystal. Trak. TM Information Flow & Management