Administrative Core Edward P Riley Ph D Principal

Administrative Core Edward P. Riley, Ph. D. Principal Investigator January, 2011 Rockville, MD

Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) l el w So Sul ik n Mattso dd Cu Administrative Riley Ch am be Zh Informatics Dysmorphology Jones Barnett ou Foroud rs Tesch e Miranda

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Developmental Projects • Funded 2 new developmental projects. – C. Tesche – R. Miranda Circulating micro. RNA Miranda Biomarkers of Fetal Alcohol Exposure Tesche A Neuroplastic Intervention

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Monthly Data Report for the Central Repository of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders December 31, 2010 Cumulative Data Submitted Dysmorphology Subjects CCA ESL KJK KJR LRB PNM PMP PMR PMS SJS SMF SMM SMS TCK TCR Total 98 52 72 66 93 26 123 222 103 237 148 98 236 32 57 1, 663 Dysmorphology Subjects No Exams Dysmorphology Exams 76 99 52 72 74 93 26 125 394 76 163 708 201 139 194 32 63 2, 435 83 134 135 138 35 118 643 56 87 204 +15 +4 177 677 +4 116 745 +1 +1 71 36 158 195 249 713 8 8 109 222 598 109 230 606 Neurobehavior II 91 +17 62 3 D Facial Imaging 46 38 55 377 113 +40 Brain Imaging 51 Demographics Static 97 +6 36 54 82 +1 +12 Demographics Dynamic II 96 Demographics Dynamic Total 96 +5 +5 37 53 81 +1 +12 +19 +18

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Administrative and Pilot Project Core Publications • • Preece, P. M. and Riley, E. P. (Editors). Alcohol, drugs and medication in pregnancy: The Outcome for the Child. Clinic in Developmental Medicine #187. London: Mac. Keith Press, 2011. Riley, E. P. , Clarren, S. , Weinberg, J. , and Jonsson, E. (Editors) Fetal Alcohol Spectrum Disorder: Management and Policy Perspectives of FASD. Weinheim: Wiley-Blackwell, 2011. Barrow, M. , and Riley, E. P. Diagnosis of the fetal alcohol syndrome: Emphasis on early detection. In Preece, P. M. and Riley, E. P. (Editors). Alcohol, drugs and medication in pregnancy: The Outcome for the Child. Clinic in Developmental Medicine #187. London: Mac. Keith Press, 2011, In press. Kaminen-Ahola, N. , Ahola, A. , Maga, A. M. , Mallitt, K. A. , Fahey, P. , Cox, T. C. , Whitelaw, E. & Chong, S. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLo. S Genetics, 2010; 6(1): e 1000811. PMCID: PMC 2797299 Mattson, S. N. , Roesch, S. C. , Fagerlund, Å. , Autti-Rämö, I. , Jones, K. L. , May, P. A. , Adnams, C. M. , Konovalova, V. , Riley, E. P. , and the CIFASD. Toward a neurobehavioral profile of fetal alcohol spectrum disorders. Alcoholism: Clinical and Experimental Research, 2010; 34: 1640 -1650. PMCID: PMC 2946199 Mc. Gee, C. L. , and Riley, E. P. The effects of prenatal alcohol exposure on brain and behavior. In Preece, P. M. and Riley, E. P. (Editors). Alcohol, drugs and medication in pregnancy: The Outcome for the Child. Clinic in Developmental Medicine #187. London: Mac. Keith Press, 2011, In press. Nguyen, T. T. , Coppens, J. , and Riley, E. P. Prenatal alcohol exposure, FAS, and FASD: An introduction. In Riley, E. P. , Clarren, S. , Weinberg, J. , and Jonsson, E. (Editors), Fetal Alcohol Spectrum Disorder: Management and Policy Perspectives of FASD. Weinheim: Wiley-Blackwell, 2011: 1 -13

Examples of Administrative Core 2010 Talks • “Effects of Alcohol on Brain Development: Understanding and Addressing the Impairments, ” presented at the 25 th National Training Institute (NTI) Zero to Three conference, Phoenix, AZ, December 2010. • “The Foetal Brain & Alcohol – Defining Foetal Alcohol Spectrum Disorder (FASD). Including a Look at Bimanual Coordination and Interventions, ” presented at The Adolescent and Children’s Trust’s (TACT) Bruised Before Birth Meeting, Birmingham, England, November 2010. • “Findings from CIFASD, ” presented at the International Workshop for Research on Fetal Alcohol Spectrum Disorder, Seoul, Korea, August 2010. • “Interagency Coordinating Committee on Fetal Alcohol Spectrum Disorders ARND Workgroup and FASD in the DSM-V, ” presented at the SAMHSA FASD Center for Excellence FASD Field Trainers Update Meeting, Orlando, FL, July 2010. • “International FASD Research Update, ” presented at the International Fetal Alcohol Spectrum Disorders (FASD) Conference: A Framework for FASD Diagnosis and Services, Sault Ste Marie, MI, April 2010. • “The Effects of Prenatal Alcohol Use on the Developing Brain, ” presented at the International Fetal Alcohol Spectrum Disorders (FASD) Conference: A Framework for FASD Diagnosis and Services, Sault Ste Marie, MI, April 2010. .

Publications from Jennifer Thomas IX. Publications (2010): Thomas, J. D. , Abou, E. J. & Dominguez, H. D. (2009). Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicology and Teratology, 31, 303 -311. Thomas, J. D. , Idrus, N. M. , Monk, B. R. , & Dominguez, H. D. (2010) Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. Birth Defects Research, 88, 827 -837. Idrus, N. M & Thomas, J. D. Fetal alcohol spectrum disorders: Experimental therapeutics and strategies for intervention. Alcohol Research and Health, In press. X. Posters and Presentations (2010): Thomas, J. D. Evidence-based Treatments for Fetal Alcohol Spectrum Disorders, International Conference on FASD, Ste Sault-Marie, MI, April 2010. Thomas, J. D. Choline availability and fetal alcohol spectrum disorders: Nutritional risk factors and potential treatments. Alcoholism: Clinical and Experimental Research, 34(6): S 194; Research Society on Alcoholism, San Diego, CA, June 2010. Thomas, J. D. , Idrus, N. & Riley, E. P. Choline Availability and Fetal Alcohol Spectrum Disorders. International Society of Biomedical Research on Alcoholism, Paris, September 2010. Thomas, J. D. Nutritional Interventions to Fetal Alcohol Spectrum Disorders. International FASD Conference, Atlanta, October 2010. Nguyen, T. T. , Chambers, C. , Keen, C. L. & Thomas, J. D. The effects of prenatal alcohol exposure on choline metabolism: Implications for the role of choline in moderating FASD. Research Society on Alcoholism, June 2011.

Thank you Edward Riley, Ph. D. San Diego State University eriley@mail. sdsu. edu

James L. Mills Received his MS in epidemiology from the University of Pennsylvania, and his M. D. from New York Medical College. His primary research interest is the etiology of birth defects. He has worked for the last decade on genetic and biochemical risk factors for NTDs and other folate-related birth defects. Directs the NICHD University of Chile Alcohol in Pregnancy Study - a prospective study in collaboration with investigators at the University of Chile in Santiago. It is designed to determine the effects of heavy alcohol exposure on the fetus. Heavy drinking women were identified by screening at prenatal care, advised on the dangers of drinking while pregnant, and asked to participate in the study. Selected Publications Avaria M, Mills JL, Kleinsteuber K, Aros S, Conley MR, Cox C, Klebanoff M, & Cassorla F. (2004). Peripheral nerve conduction abnormalities in children exposed to alcohol in utero. J Pediatr, 144: 338 -343. Aros S, Mills JL, Torres C, Henriquez C, Fuentes A, Capurro T, Mena M, Conley M, Cox C, Signore C, Klebanoff M, & Cassorla F. (2006). Prospective identification of pregnant women drinking four or more standard drinks (> or = 48 g) of alcohol per day. Subst Use Misuse, 41(2): 183 -197. Also involved in research on Austism Spectrum Disorders and Neural Tube Defects

James L. Mills Received his MS in epidemiology from the University of Pennsylvania, and his M. D. from New York Medical College. His primary research interest is the etiology of birth defects. He has worked for the last decade on genetic and biochemical risk factors for NTDs and other folate-related birth defects. Directs the NICHD University of Chile Alcohol in Pregnancy Study - a prospective study in collaboration with investigators at the University of Chile in Santiago. It is designed to determine the effects of heavy alcohol exposure on the fetus. Heavy drinking women were identified by screening at prenatal care, advised on the dangers of drinking while pregnant, and asked to participate in the study. Also involved in research on Austism Spectrum Disorders and Neural Tube Defects

James L. Mills Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis. Aros S, Mills JL, Iñiguez G, Avila A, Conley MR, Troendle J, Cox C, Cassorla F. Horm Res Paediatr. 2010 Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day. Signore C, Aros S, Morrow JD, Troendle J, Conley MR, Flanigan EY, Cassorla F, Mills JL. Alcohol Clin Exp Res. 2008 Nov; 32(11): 1893 -8. Eye malformations in children with heavy alcohol exposure in utero. Flanigan EY, Aros S, Bueno MF, Conley M, Troendle JF, Cassorla F, Mills JL. J Pediatr. 2008 Sep; 153(3): 391 -5. Choline concentrations in human maternal and cord blood and intelligence at 5 y of age. Signore C, Ueland PM, Troendle J, Mills JL. Am J Clin Nutr. 2008 Apr; 87(4): 896 -902. Prospective identification of pregnant women drinking four or more standard drinks (> or = 48 g) of alcohol per day. Aros S, Mills JL, Torres C, Henriquez C, Fuentes A, Capurro T, Mena M, Conley M, Cox C, Signore C, Klebanoff M, Cassorla F. Subst Use Misuse. 2006; 41(2): 6. Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. Molloy AM, Mills JL, Cox C, Daly SF, Conley M, Brody LC, Kirke PN, Scott JM, Ueland PM. Am J Clin Nutr. 2005 Oct; 82(4): 836 -42. Peripheral nerve conduction abnormalities in children exposed to alcohol in utero. Avaria Mde L, Mills JL, Kleinsteuber K, Aros S, Conley MR, Cox C, Klebanoff M, Cassorla F. J Pediatr. 2004 Mar; 144(3): 338 -43. PMID: 15001939

Cathy Spong Received her MD 1991 from University of Missouri, College of Medicine, Kansas City Catherine Spong, M. D. , joined NICHD in 2000 and is board certified in maternal-fetal medicine and obstetrics and gynecology. Dr. Spong is the program scientist for the Maternal Fetal Medicine Units Network and has been Branch chief since January 2001. She is an associate editor of Obstetrics & Gynecology and William¿s Obstetrics, while also serving as a maternal-fetal medicine specialist at INOVA Alexandria hospital. Dr. Spong is the NICHD liaison for the ACOG Committee on Obstetric Practice, the Society for Maternal-Fetal Medicine Executive Board, and the Liaison Committee of Obstetrician/Gynecologists. She is a fellow of ACOG and a member of the Society for Maternal-Fetal Medicine, the Society for Gynecologic Investigation, the Society for Neuroscience, and the Perinatal Research Society. Beating the Belly Bloat

Selected publications • • Prevention of the alcohol-induced changes in brain-derived neurotrophic factor expression using neuroprotective peptides in a model of fetal alcohol syndrome. Incerti M, Vink J, Roberson R, Benassou I, Abebe D, Spong CY. Am J Obstet Gynecol. 2010 May; 202(5): 457. e 1 -4. . Treatment with neuropeptides attenuates c-fos expression in a mouse model of fetal alcohol syndrome. Incerti M, Vink J, Roberson R, Abebe D, Spong CY. Am J Perinatol. 2010 Oct; 27(9): 743 -8. Reversal of alcohol-induced learning deficits in the young adult in a model of fetal alcohol syndrome. Incerti M, Vink J, Roberson R, Wood L, Abebe D, Spong CY. Obstet Gynecol. 2010 Feb; 115(2 Pt 1): 350 -6. Alterations in phosphorylated cyclic adenosine monophosphate response element of binding protein activity: a pathway for fetal alcohol syndrome-related neurotoxicity. Roberson R, Cameroni I, Toso L, Abebe D, Bissel S, Spong CY. Am J Obstet Gynecol. 2009 Feb; 200(2): 193. e 1 -5. Understanding the mechanism of learning enhancement: NMDA and GABA receptor expression. Toso L, Johnson A, Bissell S, Roberson R, Abebe D, Spong CY. Am J Obstet Gynecol. 2007 Sep; 197(3): 267. e 1 -4. PMID: 17826414 Neuroprotective peptides prevent some alcohol-induced alteration in gamma-aminobutyric acid A-beta 3, which plays a role in cleft lip and palate and learning in fetal alcohol syndrome. Toso L, Roberson R, Abebe D, Spong CY. Am J Obstet Gynecol. 2007 Mar; 196(3): 259. e 1 -5. PMID: Prenatal alcohol exposure alters GABA(A)alpha 5 expression: a mechanism of alcoholinduced learning dysfunction. Toso L, Roberson R, Woodard J, Abebe D, Spong CY. Am J Obstet Gynecol. 2006 Aug; 195(2): 522 -7. Protection against prenatal alcohol-induced damage. Spong CY. PLo. S Med. 2006 Apr; 3(4): e 196.

William Fifer Georgetown University BA , University of North Carolina, Ph. D. in Devel Psychology Fellowship: Albert Einstein College of Medicine Dr. Fifer's research interests focus on fetal and neonatal behavioral, perceptual and autonomic nervous system development. Current investigations in his laboratory include studies of fetal, newborn and premature infant neurobehavioral responses to sensory stimulation, infant sleep physiology , and the effects of in utero experience on later neurodevelopment. He has active collaborations within the Departments of Psychiatry, Obstetrics, Pediatrics, Behavioral Medicine at Columbia and the Indian Health Service that focus on the effects of maternal anxiety, depression and alcohol use during pregnancy on the developing fetus, the relationship between diet and sleep in premature infants, development of autonomic control, and assessment of risk for neurological disorders including Sudden Infant Death and Autism. He and his colleagues are currently involved in large fetal/infant cohort studies New York City , in North and South Dakota , and in Cape Town , South Africa.

Selected publications • Fifer WP, Byrd DL, Kaku M, Eigsti IM, Isler JR, Grose-Fifer J, Tarullo AR, Balsam PD. : Newborn infants learn during sleep. Proceedings of the National Academy of Medicine 2010; 107(22): 10320 -3 Sahni R, Schulze KF, Ohira-Kist K, Kashyap S, Myers MM, Fifer WP: Interactions among peripheral perfusion, cardiac activity, oxygen saturation, thermal profile and body position in growing low birth weight infants. . Acta Paediatrica 2010; 99(1): 135 -139 Fifer WP, Fingers ST, Youngman M, Gomez-Gribben E, Myers MM: Effects of alcohol and smoking during pregnancy on infant autonomic control. . Developmental Psychobiology 2009; 51(3): 234 -242 Sahni R, Fifer WP, Myers MM. : Identifying infants at risk for sudden infant death syndrome. . Current Opinions in Pediatrics 2007; 19(2): 145 -9 Nomura Y, Brooks-Gunn J, Davey C, Ham J, Fifer WP. : The role of perinatal problems in risk of co-morbid psychiatric and medical disorders in adulthood. . Psychological Medicine 2007; 37(9): 1323 -34