A Framework for Communicating, Collaborating, and Coordinating Michael Huerta Co-Chair, NIH Blueprint Coordinating Committee Associate Director, NIMH
Nervous System Disorders • Account for 6 of the top 10 causes of death* • Affect 1 in 3 Americans • Cost over $500 billion per year** • Major impact on: – academic performance – workplace productivity – social functioning – quality of life Sources: *CDC; **Sf. N Fact Page
Urgent need to: • Accelerate progress in neuroscience • Maximize bang for the research buck
NIH Blueprint for Neuroscience Research • • 16 Institutes, Centers, Offices (ICOs) Focus on cross-cutting activities Communicate and adopt best practices Coordinate the planning & funding of: – Research and development of tools – Education, training, & career development – Research resources • $26 million from ICOs (0. 6 % neuroscience) • $12 million from NIH Office of the Director
Neuroscience Blueprint Participating ICOs NCCAM NCRR NEI NIAAA NIBIB NIDA NIEHS NIDCD NICHD NIDCR NIGMS NIMH NINDS NINR OBSSR
Fiscal Year 2005 Initiatives • GENSAT (gene expression map) Expansion • Microarray Consortium Expansion • Pediatric MRI of Normal Development Expansion • Neurobiology of Disease Curriculum Development • International Neuroinformatics Coordinating Facility • Neuroscience Information Framework
Fiscal Year 2006 Initiatives • Neuromouse – repatriate, develop, and validate driver mouse lines for important genes • Institutional Training Initiatives – Neuroimaging – Physics to Physiology – Computational neuroscience – Neurobiology of disease • Interdisciplinary Core Facility Centers • Neuroimaging Tools and Resources – Clearinghouse for informatics (NITRC) – Imaging activation in ms & mm resolution • Neuroepidemiology Instrument
FY 2007: Neurodegeneration • Biomarkers Research • Therapeutics Delivery Strategies • Interdisciplinary Career Development • Interdisciplinary Postdoctoral Training Human retinal degeneration
FY 2008: Neurodevelopment • Monoclonal Antibodies • Tools for Marking Neural Circuits • Gene Expression Map of the Primate Brain Normal Brain Development, Age 5 - 20
FY 2009: Neuroplasticity • Probes and instrumentation for monitoring and manipulating neuroplasticity
FY 2010: Blueprint Grand Challenges
Blueprint Grand Challenge: The Human Connectome Project • Purpose -To develop and share knowledge about the structural and functional connectivity of the healthy, adult human brain • Goals - To have delivered at the end of five years: – Optimized non-invasive imaging tools and methods to collect human connectivity data, in vivo – High-quality, well-characterized, multi-modal, quantitative datasets of human connectivity linked to genetic & behavioral data from hundreds of subjects – Dissemination of data, models, and tools to the research community via outreach activities and an informatics platform
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