Скачать презентацию A chemotactic gradient sequestered on endothelial heparan sulfate Скачать презентацию A chemotactic gradient sequestered on endothelial heparan sulfate

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A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils by Sara Massena, Gustaf Christoffersson, Elina Hjertström, Eyal Zcharia, Israel Vlodavsky, Nora Ausmees, Charlotte Rolny, Jin-Ping Li, and Mia Phillipson Blood Volume 116(11): 1924 -1931 September 16, 2010 © 2010 by American Society of Hematology

Localized extravascular chemokine release induces directional intraluminal crawling of neutrophils toward infection site. Sara Localized extravascular chemokine release induces directional intraluminal crawling of neutrophils toward infection site. Sara Massena et al. Blood 2010; 116: 1924 -1931 © 2010 by American Society of Hematology

Localized extravascular chemokine release results in decreased crawling distance and crawling velocity. Sara Massena Localized extravascular chemokine release results in decreased crawling distance and crawling velocity. Sara Massena et al. Blood 2010; 116: 1924 -1931 © 2010 by American Society of Hematology

Leukocyte transmigration is dependent on HS sequestration of chemokines on apical venular endothelium. Sara Leukocyte transmigration is dependent on HS sequestration of chemokines on apical venular endothelium. Sara Massena et al. Blood 2010; 116: 1924 -1931 © 2010 by American Society of Hematology

Chemokine gradients sequestered by endothelial HS effectively directs crawling leukocytes toward transmigration sites closer Chemokine gradients sequestered by endothelial HS effectively directs crawling leukocytes toward transmigration sites closer to the infection. Sara Massena et al. Blood 2010; 116: 1924 -1931 © 2010 by American Society of Hematology

Venular, but not arterial, endothelium sequesters MIP-2, and the chemokine is concentrated in junctional Venular, but not arterial, endothelium sequesters MIP-2, and the chemokine is concentrated in junctional regions. Sara Massena et al. Blood 2010; 116: 1924 -1931 © 2010 by American Society of Hematology

Random crawling in hpa-tg venules results in a decreased ability to clear bacterial infections. Random crawling in hpa-tg venules results in a decreased ability to clear bacterial infections. Sara Massena et al. Blood 2010; 116: 1924 -1931 © 2010 by American Society of Hematology