4 TH WORLD BANK ACE WORKSHOP Sika Menka

4 TH WORLD BANK ACE WORKSHOP Sika Menka (Monitoring & Evaluation Officer) West African Centre for Cell Biology of Infectious Pathogens

CENTRE TEAM • Dr. Gordon A. Awandare - Director • Prof. Kwadwo A. Koram - Deputy Director • Dr. Olukemi Amodu - Representative of regional partners • Mr. Collins Amofah - Finance Focal Person • Ms. Sika Menka - Monitoring and Evaluation Focal Person • Mrs. Constance Kocke - Procurement Focal Person

MISSION OF WACCBIP o The mission of WACCIP is to: Improve diagnosis, prevention and control of infectious diseases in sub-Saharan Africa by providing advanced level training and research excellence on the cell and molecular biology of infectious pathogens.

AWARDS AND ACHIEVEMENTS o WACCBIP- Wellcome Trust DELTAS Africa Initiative • The centre will receive £ 5. 1 million over 5 years for human genetics training of 15 Ph. Ds and 12 Postdoctoral fellows o Grants awarded to students • Noguchi Graduate Research Scheme – 6 MPhil students awarded • DANIDA-Malaria Vaccine Research and Capacity building in Ghana – full scholarships for 4 Ph. D Students • 2 Royal Society/Leverhulme Grants – scholarships for 2 Ph. D students • AIMS – scholarship for 1 Ph. D student • Building Strong Universities (BSU) II project - scholarships for 2 Ph. D students

Program Activities and their Disbursement Linked Indicators o DLI 2. 1 - Short courses launched • 1 st Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July, 2014) Topics Number of students • • 10 Students Successful diagnostics in use today Careers in Science in Ghana Understanding trypanosomes Investigating human rotavirus Erythrocyte invasion mechanisms used by Plasmodium falciparum • Science funding (4 females, 6 males, 0 regional)

Program Activities and their Disbursement Linked Indicators o DLI 2. 1 - Short courses launched • 2 nd Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July, 2015) Topics Number of students • Introduction to advance diagnostic 15 students tools in the control and treatment infectious diseases (7 females, 8 males, 3 regional) • Career opportunities in Science • Bioinformatics and sequence analysis • Molecular basis for host-pathogen interactions • Recombinant protein production • Grantsmanship

Program Activities and their Disbursement Linked Indicators o Short courses planned for next year • WACCBIP-American Society of Cell Biology workshop (January 18 - 29, 2016) • 3 rd Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July 4 -15, 2016)

Program Activities and their Disbursement Linked Indicators o DLI 2. 2 - New Masters programme • • 1 st Cohort: 30 students (7 female, 23 male, 4 regional) MSc Biochemistry - 6 students MPhil Biochemistry- 2 student MPhil Molecular Biology – 2 students MPhil Molecular Cell Biology of Infectious Diseases (MCBI) - 20 students

Program Activities and their Disbursement Linked Indicators o DLI 2. 2 - New Masters programme • • 2 nd Cohort, 22 students (9 female, 13 male, 0 regional) MSc Biochemistry – 1 student MPhil Biochemistry - 2 students MPhil Molecular Biology - 3 students MPhil Molecular Cell Biology of Infectious Diseases (MCBI) - 16 students

Program Activities and their Disbursement Linked Indicators o DLI 2. 3 - New Ph. D Programmme • Ph. D Biochemistry • Ph. D Molecular Cell Biology of Infectious Diseases (MCBI) -1 st cohort: 15 students; 7 females, 8 males, 0 regional - 2 nd cohorts: 13 students; 5 females, 8 males, 2 regional

Program Activities and their Disbursement Linked Indicators • DLI 2. 4 - Outreach Periods/ Internships Faculty internships – 5 (1 female, 4 male, 1 regional) Cambridge CAPREx Programme WACCBIP Student internship - 6 (6 female, 0 regional) London School of Hygiene and Tropical Medicine, UK University of Cambridge, UK Novartis, Switzerland University of Copenhagen, UK Pasteur Institute, France

Program Activities and their Disbursement Linked Indicators o DLI 2. 5 - Accreditation • National Accreditation o New programmes (MPhil MCBI and Ph. D MCBI) assessed and accredited by National Accreditation Board • International reviews and Accreditation o The ITC of ASCB reviewed and advised on all new curricula o Visit by the Society of Biology, UK later this year subject to availability of funds

Program Activities and their Disbursement Linked Indicators o DLI 2. 6 - Published Articles • 38 internationally recognized publications accrued between March, 2014 - August, 2015 by WACCBIP faculty • 4 publications co-authored with regional partners.

Program Activities and their Disbursement Linked Indicators o Publications co-authored with regional partners. 1. Narh, C. A. , Mosi, L. , Quaye, C. , Dassi, C. , Konan, D. O. , Tay, S. C. K. , de Souza, D. K. , Boakye, D. A. , & Bonfoh, B. (2015). Source Tracking Mycobacterium ulcerans Infections in the Ashanti Region, Ghana. PLo. S Neglected Tropical Diseases, 9(1): 18 2. Bowyer, P. W. , Stewart, L. B. , Aspeling-Jones, H. , Mensah-Brown, H. E. , Ahouidi, A. D. , Amambua-Ngwa, A. , Awandare, G. A. , & Conway, D. J. (2015). Variation in Plasmodium falciparum Erythrocyte Invasion Phenotypes and Merozoite Ligand Gene Expression across Different Populations in Areas of Malaria Endemicity. Infection and Immunity, 83(6): 2575 -82 3. Narh, C. A. , Mosi, L. , Quaye, C. , Tay, S. C. K. , Bonfoh, B. , & de Souza, D. K. (2014). Genotyping tools for Mycobacterium ulcerans- drawbacks and future prospect. Mycobacterial Diseases, 4(2) 4. Ghansah, A. , Amenga-Etego, L. , Amambua-Ngwa, A. , et al. (2014). Monitoring parasite diversity for malaria elimination in sub-Saharan Africa. Science, 345(6202), 1297 -1298

Program Activities and their Disbursement Linked Indicators o Internationally recognized publications by WACCBIP faculty 1. 2. 3. 4. Asante-Poku, A. , Otchere, I. D. , Danso, E. , Mensah, D. D. , Bonsu, F. , Gagneux, S. , & Yeboah-Manu, D. (2015). Evaluation of Geno. Type. W MTBDR plus for the rapid detection of drug-resistant tuberculosis in Ghana. International Journal of Tuberculosis and Lung Disease. 19(8): 954 -959 Tsouh, P. V. F. , Addo, P. , Yeboah-Manu, D. , & Boyom, F. F. (2015). Methods used in preclinical assessment of anti-Buruli ulcer agents: A global perspective. Journal of Pharmacological and Toxicological Methods. 73: 27 -33 Nguta, J. M. , Appiah-Opong, R. , Nyarko, A. K. , Yeboah-Manu, D. , Addo, P. G. A. (2015). Medicinal plants used to treat TB in Ghana. International Journal of Mycobacteriology. 4(2): 116 -123 Badu, K. , Gyan, B. , Appawu, M. , Mensah, D. , Dodoo, D. , Yan, G. , Drakeley, C. , Zhou, G. , Owusu-Dabo, E. , & Koram, K. A. (2015). Serological evidence of vector and parasite exposure in Southern Ghana: The dynamics of malaria transmission intensity. Parasites and Vectors. 8(1), 861

Program Activities and their Disbursement Linked Indicators 5. Duffy, C. W. , Assefa, S. A. , Mac. Innis, B. , Abugri, J. , Amoako, N. , Owusu-Agyei, S. , Anyorigiya, T. , Kwiatkowski, D. P. , Conway, D. J. & Awandare, G. A. (2015). Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity. BMC Genomics, 16: 527 6. Adjimani, J. P. & Asare, P. (2015). Antioxidant and free radical scavenging activity of iron chelators. Toxicology reports, 721 -728 7. Anum, D. , Kusi, K. A. , Ofori, M. F. , Koram, K. A. , , Dodoo, D. , et al. (2015). Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum Celltraversal protein for ookinetes and sporozoites (Cel. TOS) in Ghanaian adults. Malaria Journal, 14(20) 8. Hori, T. , Koram, K. , Nyarko, A. , Okine L. , Edoh, D. , et al. (2015). Procyanidin trimer C 1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus. Biochemical and Biophysical Research Communications, 459(2): 28893 9. Mensah-Brown, H. E. , Amoako, N. , Abugri, J. , Conway, D. J. , Awandare, G. A. , et al. (2015). Analysis of erythrocyte invasion mechanisms of Plasmodium falciparum clinical isolates across three endemic areas within one country. The Journal of Infectious Diseases, pii: jiv 207.

Program Activities and their Disbursement Linked Indicators 10. Stoler, J. , Delimini, R. K. , Bonney, K. J. H. , Oduro, A. R. , Owusu-Agyei, S. , Fobil, J. N. , & Awandare, G. A. (2015). Evidence of recent Dengue exposure among malaria parasite-positive children in three urban centers in Ghana. The American Journal of Tropical Medicine and Hygiene, 92(3), 497 -500 11. Asante-Poku, A. , Yeboah-Manu, D. , Otchere, I. D. , et al. (2015). Mycobacterium africanum is associated with patient ethnicity in Ghana. PLo. S Neglected Tropical Disease, 9(1): e 3370 12. Ocloo, A. , Appiah‐Opong, R, Chama, M. A. , et al. (2015). An In Situ Study on the Effects of Extracts of Taraxacum Officinale, Paulliniia Pinnata and Thonningia Sanguinea on Mitochondrial Function. Journal of Food Biochemistry 39(1): 55 -63 13. Suzuki, M. , Koram, K. , Ohta, N. , Boakye, D. A. , et al. (2015). New anti-trypanosomal active tetracyclic iridoid isolated from morinda lucida benth. Bioorganic and Medicinal Chemistry Letters, 25(15), 3030 -3033. doi: 10. 1016/j. bmcl. 2015. 003 14. Asiedu-Larbi, J. , Adjimani, J. P. , Okine, L. K. N. , Addy, M. E. , et al. (2014). Efficacy studies on Mist Diodia, a herbal preparation for the management of hypertension in rodents. Medicinal & Aromatic Plant Research Journal, 2(1), 6 -17.

Program Activities and their Disbursement Linked Indicators 15. Amoako, N. , Asante, K. P. , Adjei, G. , Awandare, G. A. , et al. (2014). Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana. PLo. S One, 9(12) 16. Bratschi, M. W. , Bolz, M. , Yeboah-Manu, D. , Ruf, M. T. , Pluschke, G. et al. (2014). Primary cultivation: factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical specimens. BMC Infectious Diseases, 14(1): 636 17. Abuaku, B. , Quaye, L. , Duah, N. , Quashie, N. , & Koram, K. (2014). Managing antimalarial drug resistance in Ghana: The importance of surveillance, Towards Effective Disease Control in Ghana: Research and policy implications (Clinical Science series No. 5 -1). Sub-Saharan publishers. ISBN: 978 -9988 -647 -50 -6 18. Adu, B. , Jepsen, M. P. , Gerds, T. A. , Kyei-Baafour, E. , Christiansen, M. , Dodoo, D. , & Theisen, M. (2014). Fc gamma receptor 3 B (FCGR 3 B-c. 233 C>A-rs 5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children. The Journal of Infectious Diseases, 209(2), 285 -9 19. Ampomah, P. , Stevenson, L. , Ofori, M. F. , et al. (2014). Kinetics of B Cell Responses to Plasmodium falciparum Erythrocyte Membrane Protein 1 in Ghanaian Women Naturally Exposed to Malaria Parasites. The Journal of Immunology, 192(11), 5236 -44

Program Activities and their Disbursement Linked Indicators 20. Asante-Poku, A. , Aning, K. G. , Boi-Kikimoto, B. , & Yeboah- Manu, D. , (2014). Prevalence of bovine tuberculosis in a dairy cattle farm and a research farm in Ghana, Onderstepoort Journal of Veterinary Research, 81(2): 716 -21 21. Asante-Poku, M. , Nyaho, S. , Borrell, S. , Comas, I. , Gagneux, S. , & Yeboah-Manu, D. (2014). Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana. Plo. S One, 9(3), e 92675. 22. Asare, K. K. , Boampong, J. N. , Afoakwah, R. , Ameyaw, E. O. , Sehgal, R. , & Quashie, N. B. (2014). Use of Proscribed Chloroquine is associated with an increased risk of Pfcrt T 76 mutation in some parts of Ghana. Malaria Journal, 13(246). 23. Asare, K. K. , Boampong, J. N. , Ameyaw, E. O. , Thomford, A. K. , Afoakwah, R. , Kwakye. Nuako, G. , Thomford, K. P. , & Quashie, N. B. (2014). Microscopic identification of possible Clonorchiasis/ Opisthorchiasis Infection in Two Ghanaian Women with an Undiagnosed Abdominal Discomfort: Two Case Report. Journal of Medical Case Reports, 8(369). 24. Awodele, O. , Tomoye, O. P. , Quashie, N. B. , et al. (2014). Gentamicin Nephrotoxicity: Animal Experimental Correlate with Human Pharmacovigilance Outcome. Biomedical Journal, doi: 10. 4103/2319 -4170. 131387.

Program Activities and their Disbursement Linked Indicators 25. Donkor, K. , Antwi, S. , Asiedu-Larbi, J. , Takyi, N. , & Okine, L. K. (2014). Sub-chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat. Medicinal and Aromatic Plants Research Journal, 2(1), 18 -27. 26. Greenwood, B. , & Koram, K. A. (2014). Malaria control in Africa: progress but still much to do. Lancet, 383(9930), 1703 -4. 27. Kusi, K. A. , Bosomprah, S. , Dodoo, D. , Kyei-Baafour, E. , Dickson, E. K. , Mensah, D. , Angov, E. , Dutta, S. , Sedegah, M. , & Koram, K. A. (2014). Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation. Malaria journal, 13(1), 103. 28. Ocloo, A. , Okpattah, W. E. , Quasie, O. , Sakyiamah, M. M. , & Okine, L. K. N. (2014). Concurrent administration of aqueous Extract of Cryptolepis sanguinolenta reduces the effectiveness of Artesunate against Plasmodium berghei in Rats. Journal of Applied Pharmaceutical Science, 4(3), 024 -028. 29. Williamson, H. R. , Aqqad, M. , Donnell, R. , Mosi, L. , Merritt, R. W. , & Small, P. L. C. (2014). Laboratory Studies on the ability of Mycobacterium ulcerans to infect through open wounds. PLo. S Neglected Tropical Disease, 8(4), e 2770

Program Activities and their Disbursement Linked Indicators 30. Röltgen, K. , Bratschi, M. W. , Ross, A. , Aboagye, S. Y. , Ampah, K. A. , Bolz, M. , Andreoli, A. , Pritchard, J. , Minyem, J. C. , Noumen, D. , Koka, E. , Um Boock, A. , Yeboah-Manu, D. , & Pluschke, G. (2014). Late onset of the serological response against the 18 k. Da small heat shock protein of Mycobacterium ulcerans in children. PLo. S Neglected Tropical Disease, 8(5), e 2904 31. Sanuade, O. A. , Anarfi, J. K. , Aikins, Ad. , & Koram, K. A. (2014). Patterns of cardiovascular disease mortality in Ghana: a 5 -year review of autopsy cases at Korle. Bu Teaching Hospital. Ethnicity and Diseases, Winter, 24(1), 55 -9 32. Stoler, J. , al Dashti, R. A. , Anto, F. , Fobil, J. N. , & Awandare, G. A. (2014). Deconstructing "malaria": West Africa as the next front for dengue fever surveillance and control. Acta Tropica, 134(1), 58 - 65 33. Tettey, C. O. , Ocloo, A. , Nagajyothi, P. C. N. , & Lee, K. D. (2014). Anti-proliferative and Anti-microbial Activities of Taraxacum officinale (Dandelion) Leaf Extracts. Journal of Applied Pharmaceutical Science, 4(3), 041 -045 34. Tettey, C. O. , Ocloo, A. , Nagajyothi, P. C. N. , & Lee, K. D. (2014). Antioxidant activity, of solvent-fractionated Taraxacum officinale (dandelion) Leaves. Journal of Herbs, Spices and Medicinal Plants, 20(4), 329 -340

Program Activities and their Disbursement Linked Indicators o DLI 2. 7 - Revenue Generated o WACCBIP- Wellcome Trust DELTAS Africa Initiative • The centre will receive £ 5. 1 million over 5 years for human genetics training of 15 Ph. Ds and 12 Postdoctoral fellows • First disbursement of $934, 098 received o The centre has been contracted to provide educational services in the areas of health to The Gambia Republic under the World Bank ACE Project • Under this arrangement, the centre is expected to will generate a total $ 214, 00. 00 for the training of: - 2 Ph. Ds= $ 146, 000. 00 - 2 Masters= $ 68, 000. 00

Program Activities and their Disbursement Linked Indicators o DLI 2. 8 - Milestones for Education & Research Environment • • Begin construction of the new building including graduate lecture rooms, seminar room, bioinformatics lab 60% completion of the building facility completed Establishment of research core facility 100% completion of the building facility

Program Activities and their Disbursement Linked Indicators o Milestone Progress • Establishment of research core facility - Opened tender and procured a flow cytometer. Awaiting delivery and installation of equipment • Begin construction of the new building including graduate lecture rooms, seminar room, bioinformatics lab - Requested tender opening for selecting a contractor for the building

First Disbursement Expenditure First Disbursement: $728, 838. 20 Academic quality • $ 130, 000 • Student Scholarships: 20 Masters and 24 Ph. Ds (Tuition fees, research costs, stipend) Partner Institutions Establishment of research core facility • • • Flow cytometer Bench top centrifuge (2) Biosafety cabinets (2) $ 332, 200 $ 40, 000 $ 26, 800 Centre management • • Administrative and staff costs Vehicle Travel cost owed to UG $ 20, 000 $110, 000 $ 15, 000 $ 50, 000 $ 35, 000 TOTAL $ 759, 000 BALANCE - $ 30, 171. 80

Program Challenges o Top 3 challenges to program include: • Recruitment of foreign/regional students • Industry partnership development • Challenges associated with importing laboratory supplies and consumables for research

Program Management Challenges o Top 2 program management/operations challenges include: • Delays in disbursement of funds • Bureaucratic procurement processes

Top Goal/Hope for the next year • Generate more revenue through: -Training/teaching contracts - Laboratory supply store - Private sector engagement (consultancy and sponsorship) • Core research facility and e-learning platform should be established • Increment in regional and female student numbers • International accreditation from So. B, UK • Embark on outreach programmes

Thank You