2013 -2015 DEPARTMENT OF CHEMISTRY AND TECHNOLOGY OF

2013 -2015 DEPARTMENT OF CHEMISTRY AND TECHNOLOGY OF ORGANIC SUBSTANCES, NATURAL COMPOUNDS AND POLYMERS

Leaders of the Department Head of the Department Professor Mun G. A. Irmuhamedova G. S. (Deputy for scientific research work) Bazhykova G. B. (Deputy teaching and educational work)

Staff potential Number of teachers - 41 Academician of NAS RK - 3 (including the All-Russian Academy of Academician unconventional and rare plants) Corresponding Member of the National Academy of Sciences RK - 2 Doctor of Chemical Sciences - 16 Candidate of chemical sciences -18 (including the candidate of technical sciences) Ph. D - 3 1

Educationalmethodical Social Educational Activities of the Department Scientific and Research International

Educational-methodical activity Specialties: Undergraduate: 5 V 072100 - chemical technology of organic substances. 4 -year training Master: 6 M 060600 - chemistry 6 M 072100 - Chemical technology of organic substances. Duration of training 2 years Ph. D Doctorate: 6 D 060600 - Chemistry, 6 D 072100 - Chemical technology of organic substances. Duration of training 3 years

Training in the following areas: • • • • • Organic chemistry; Theoretical Foundations of Organic Chemistry; Functional derivatives of organic compounds; Organic chemistry of aliphatic series; Chemistry of Natural Compounds; Chemistry of cyclic compounds; Theoretical bases of technology of organic substances; Technology for processing of medicinal plants; Standardization and certification of organic substances; Chemistry and technology of organic substances; Macromolecular Chemistry; Chemistry and physics of polymers; Chemistry and physics of organic substances; New polymeric materials; Chemical technology of organic substances; Technological bases of polymeric composite materials; Functional hydrophilic polymers; Chemical engineering plastics production and processing; Radiation chemistry of polymers and others.

Teaching and laboratory base • The department has the following research laboratories and workshops: • Organic synthesis of new organic compounds and materials, • Chemistry of Natural Compounds, • Immobilization of biologically active compounds to the polymeric matrix, • Macromolecular chemistry. • All laboratories are equipped with instrumentation: IR and UV spectrophotometer Educational Laboratory Center «Shimadzu» ; liquid chromatography with diode array detection Agilent 1100 Series; vacuum distillation unit «Normshliff» , a device for measuring mechanical properties of materials, roternye evaporators, automatic viscometers, rheometers, analytical and electronic scales, freeze drying, etc.

Material provision 18 Control and measuring block module for measuring the viscosity and thixotropic properties of materials Reometer PHYSICA MCR 102

Material provision Transelyuminator CO 2 supercritical fluid extractor UV spectrometer 19

Scientific Directions Organic synthesis Chemistry of Natural Compounds Macromolecular Chemistry and immobilization drugs polymer -supported 2

Scientific Projects and Researches Economic agreements International Grants 1 2 3 Basic and applied research 15

Implementation of research results in medicine According to the project "Investigation of the chemical composition of substances extracted from the aerial parts of the plant species and L. gmelinii L. myrianthum, preclinical studies of substance L. gmelinii and introduction of technological scheme of its receipt with the requirements of GMP» Implemented the introduction of grass L. gmelinii in medicine, received registration Mo. H, the monograph "Grass Limonium gmelinii" accepted for publication in the GF RK (2013 -2014 years). The 5% ointment "Limonidin" is registered in the public register of issued opinions on the safety and quality. Industrial regulations on the production of the ointment "Limonidin" approved of "Himfarm". Application: The anti-inflammatory and antiviral agent 5

Commercialization of technologies Herbal herbal raw material Kazakhstan (Kermek Gmelin, camel thorn) Anesthetic, analgesic, antispasmodic "Rihlokain" Polymeric hydrogels 13

Research projects 2015 -2018 Zhumagalieva Sh. N. • Development of polymeric formulations plant extract tamarisk Beisebekov M. K. • «Development of new polymer-clay composite and cryosorbents of surfactants and heavy metals» Zhusupova G. E. • Technology for processing the aerial part of industrially important, wild plants for the Republic of Kazakhstan on the basis of their original drugs as tinctures, tablets and capsules and their comprehensive study.

Research projects 2015 -2018 Zhusupova G. E. • "Investigation of the chemical composition of substances extracted from the aerial parts of the plant species and L. gmelinii L. myrianthum, preclinical studies of substance L. gmelinii and introduction of technological scheme of its receipt with the requirements of GMP» • Development of technology for the directed synthesis of new nitrogen- and phosphoruscontaining biologically active substances based on natural hydroxyanthraquinones Korulkin D. Yu. • Development of universal, cost-effective methods for the selective isolation of industrially important class of biologically active substances from plants of Kazakhstan Muzychkina R. A.

16 Attracting in research project on a paid basis:

20 International scientific partnership Tsynzyansky Technical Institute of Physics and Chemistry University of Rostock (Germany) University of Reading (England) Universiti Sains Malaysia (Phangan) Research Institute of Chemistry, University of Karachi (Pakistan) University of Potsdam (Germany) Crimea State Medical University Partners University of Memphis (USA) University of Mississippi (USA) Hodzhateppe University (Turkey, Ankara)

Direction of cooperation timeline Partnerships with academic institutions and centers of RK Direction of cooperation timeline Name Partners, Name of organization, laboratory Joint Stock Company "Scientific Center of antiinfective drugs" president Ilyin A. I. LLC "Pharmaceutical company" Romat "Pavlodar, Kazakhstan Rakish TA, TOO president of FC "Romat" As part of the project on technology to create a new drug "Limonidin" Contract number 2 December 2013 Joint work on drawing up provisional analytical normative document on substance Alhidin 2012 -2015 JSC "Himfarm" The Director-General V. Gryglevich National Center for Expertise of medicines and medical products Mo. H First Deputy. gene. Director NTSELS MOH Sabdenalieva DM Contract number CI 2013/16 between BPH and CFHMA NTSELS Mo. H regarding preclinical tablets "Limonidin" Study of mielostimuliruyuschih properties of herbal remedies contract № 2 from 03. 28. 2013 A subsidiary of the state enterprise on the right of business "Research Institute of Ecology» RSE on PVC "Kazakh National University. Al-Farabi “ Prof. Tuleuhanov S. T. Institute of Nuclear Physics Deputy. Director of INP Chakra P. Creating a new production technology of polymer hydrogel materials biomedical purposes, structured nanosilver 2012 -2015 Explore the inhibitory activity of the drug "Tamariksidin" Contract for the performance of work number 8 on October 20, 2013

Joint research laboratory of international level Organized jointly by the chemical laboratory between the University of Rostock and Kaz. NU Prof. Peter Langer -zaveduyuschy Laboratory of Organic Chemistry and employee Kelzhanova N. 21

27 Scientific publications for 2014 Name Plan Fact 5 27 The number of scientific papers published in international journals, Thomson Reuters on having (ISI Web of Knowledge, Thomson Reuters) non-zero impact factor 5 9 The number of scientific papers published in international scientific journals included in the database Scopus 5 18 70 31 60 28 50 56 The number of scientific papers published in international scientific journals with information according to Thomson Reuters database companies and Scopus (ISI Web of Knowledge, Thomson Reuters) non-zero impact factor Number of publications PPP Kazakh publications on the recommended list KKSON the MES (except monographs) Number of publications in the materials of national and international conferences held in the Republic of Kazakhstan Number of publications in journals, proceedings of international conferences of the near abroad (except monographs)

Scientific groups of the department "Organic", the head of c. ch. sh Dyusebaeva M. D. • The direction of the circle: fine organic synthesis and chemistry of natural compounds. Annually circle "Organic" conducts scientific game "Diaries Organic" «Полимерщик» , the head of c. ch. sh Sarova N. B. • The direction of the circle: research in the areas of modern polymer science

Membership staff of the department the editorial boards of international publications. • Mun G. A. – member of the editorial board of the International Journal of Eurasian Chemical-Technological Journal and the International Journal of Biology and Chemistry • Irmukhametova G. S. - member of the editorial board of the International Journal of Eurasian Chemical-Technological Journal and the International Journal of Biology and Chemistry

Social and educational work Education within the educational process Working with scientific associations, creative circles Social work Cultural events Work supervisors and advisors in the department and faculty Organization and participation in seminars, conferences and round tables Participation in competitions, regional and citywide events

International awards in the fields of education, science and technology Zhilkibaev O. T. and Korulkin D. Yu. - Diplomas and gold medals of the European scientific and industrial chamber «Diploma di Merito» per advanced teaching and research activities Mun G. A. - Certificate of Merit for outstanding contribution to the development of science and technology and international scientific cooperation from Association of Scientific and Technical Societies Koreans Sultanova N. A. awarded an honorary diploma and a badge "Winner of the contest of scientific papers" for successes in research International Foundation "Scientific Partnership", Chernogolovka, Russia 28

Named premium of the Republic of Kazakhstan in the field 29 Senior Lecturer Kayralapova G. Zh. won the competition of scientific and innovative projects "Parasat" A grant MES PK "The best teacher of the university“ Korulkin D. Yu.

Republican competition of scientific research work of students 30 1. Master student 2 years of training Shevchenko A. S. - A diploma and a scholarship of the Republican contest Foundation of the First President of the Republic of Kazakhstan - Leader of the Nation 2. Master student 2 years of training Bagitova Zh. received presidential scholarship RK. 3. 3 rd year student Derbeneva Dariya - was awarded the diploma of 3 degrees on the 39 th Republican scientific-practical conference MAN RK 4. 3 rd year student Kurmanova Diana - was awarded the diploma of 2 degrees on the 39 th Republican scientific-practical conference MAN RK

Sponsorship scholarships for students 31 The scholarship is named after Prof. T. K. Chumbalova students 4 and 1 year of study "Chemical technology of organic substances" and "Chemistry"- Dysip Rustem and Amanzholkyzy Arailym The scholarship is named after Prof. Sharifkanova A. Sh. 4 years of study a student specialty "Chemical technology of organic substances " Gabbasova Sabina The scholarship is named after academician of NAS RK EM Shaikhutdinova students 4 year of study "Chemical technology of organic substances" Zhubatov Darkhan and Alimkhanova Sholpan

Scientific and educational works According to the results of research and co-workers published • more than 600 articles, • 8 monographs, • 12 teaching aids • 1 textbook. The results of research are protected • 55 patents and certificates of Kazakhstan • 20 pharmacopoeia articles RK • 10 experimental-industrial regulations.

Implementation of the Department "Alhidin" Authors: prof. Abilov ZA, prof. Burasheva G. SH - Anti-inflammatory, antitumor, healing wounds "Limonidin" Authors: prof. Abilov ZA, prof. Zhusupova GE - Anti-inflammatory, antiviral, hepatoprotective agent "Sanjar" Authors: prof. Abilov ZA, prof. Zhusupova GE – – Anti-inflammatory, wound healing, antiviral and immunomodulatory agent "Biosed-K" Authors: prof. Korulkin DY, Abilov ZA - Anti-inflammatory, anti-viral agent

Polymer formulations of biologically active substances l l l The theory of polymerization processes developed 100 new polymers synthesized A large amount of basic information about the reaction mechanism, structure and properties of new polymers are received Principles of operation of a wide range of polymeric materials are installed In medical practice introduced bandages to treat wounds and burns, contact gel for ultrasound diagnosis, implant material for internal arthroplasty "Glikogel" and others. New efficient dosage forms (ointments, gels, films) sustained-release polymer-based organic and inorganic origin and preparations obtained in the department: anesthetic effect "Rihlokain" and anti - "Alhidin"