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MICROBAN OVERVIEW Cipherlab Co. Ltd August 3 rd 2010 2
Agenda Overview of Microban. • Microban Overview: Who we are and what we do. • Microban Value Proposition: How Microban creates value for its partners. Why use Microban additives? • Microban Technology: Choice of antimicrobial / test methods / How antimicrobials function: What are the benefits? • Microban Support: How we help our partners.
MICROBAN OVERVIEW 4
Microban International, Ltd. Microban is the world’s leading provider of safe, durable and effective built-in antibacterial solutions. Microban Americas Ø Charlotte, USA Ø Montreal, Canada Ø Sao Paulo, Brazil Ø Mexico City, Mexico Microban Europe Ø Cannock, U. K. Ø Frankfurt, Germany Ø Milan, Italy Ø Barcelona, Spain Microban Asia Pacific Ø Hong Kong Ø Shenzhen, China
Microban Manufacturing & Warehousing Footprint Microban supports customers on a regional level with local manufacturing and export of its additive systems, and is expanding its manufacturing base to Asia. North America Ø Charlotte, USA (Polymers & Formulations) Ø Export to EU, Central & South America, and Asia (Polymers & Formulations) Europe Ø Liverpool, U. K. (Polymers) Asia Pacific Ø Hong Kong – Warehouse (Polymers & Formulations) Ø Shenzhen, China (Polymers)
BUILT-IN TO MORE THAN 750 PRODUCTS BY OVER 150 LEADING MANUFACTURERS AROUND THE WORLD
Microban Partners - Selection Microban is privileged to help these and other industry-leading companies around the world improve and differentiate their products. 8
Our impressive reach towards consumers Microban – we are up to the challenge ü In the Home ü Hospitals, Clinics, Surgeries ü Hotel, Restaurants, Catering Venues ü Offices, Waiting Rooms, Care Homes ü Supermarkets, Shopping Centres ü Other Public Venues ü Airports, Public Transport Venues ü Gyms, Leisure, Pools & Spa Centres ü Museums, Schools, Universities and, we are looking at new areas all of the time. . . 9
Example product materials we already treat 10
MICROBAN VALUE PROPOSITION 11
Microban Value Proposition We help our partners strengthen their businesses by creating a valuable point-ofdifferentiation for their products through a compelling ingredient brand. For companies trying to strengthen their businesses and address core business challenges. Microban represents an alternative business strategy that brings value by providing a compelling and enduring point of product differentiation … And we do this by providing a complete ingredient brand solution including: • The leading antimicrobial brand • Innovative technical solutions • Patent protection (when available) • Regulatory support • Ingredient branding marketing expertise
The power of Microban ingredient branding Since 1996, Microban have been driving consumer product sales through innovation, improved quality, product longevity & enhanced consumer appeal • • Visible Cleanliness – Product cleanliness is improved with our antimicrobial and / or antifungal solution • Invisible Cleanliness – Microbes are invisible. Their growth is proven to be significantly controlled by Microban technology • 13 Extend Product Life – The life of a product will be extended when using Microban – we restrict typical microbial and fungal degradation Odour Reduction – Microbes can cause noxious odours. Using Microban naturally reduces odours and improves product appeal for consumers
MICROBAN TECHNOLOGY 14
Microban Technology • Plastics – Antimicrobial is incorporated during extrusion for thermoplastics or by addition to liquid resin for thermosets – Full range of plastics, from polyolefins to polystyrenes and polycarbonate to unsaturated polyesters and acrylics • Textiles – Incorporated via standard textile processes such as the dye bath or in surface finishes such as softeners and permanent press finishes • Coatings – Mixed with latex or solvent-based resins – Addition rates into the coating depend on the application rate of the coating on the substrate • Ceramics – Secondary glaze on tile surfaces • Metals – Epoxy powder coatings or nickel / chrome electroplating
Choice of Antimicrobial The available choices for antimicrobials will depend on: • Efficacy desired – Antibacterial – Anti-fungal • Processing – Process conditions, particularly temperature – Materials used for part • • • Properties desired (e. g, clarity) Cost Regulatory approvals – Approval for specific use – Food & water contact approvals, if needed for water. – Approved use limits
Benefit – Improved Cleanliness 2 log reduction in average CFUs - Treated boning knives - Untreated boning knives Reduction in samples with high levels of contamination Results from field study conducted in Sainsbury food preparation facilities. Sainsbury is a major British supermarket chain. • Does not necessarily lead to sterile surfaces • Provides continuous action as compared to disinfection • Does not readily transfer to skin, food, or other contact surfaces
Average bioburden wo/ cleaning Average bioburden w/ cleaning 0 2 4 6 8 10 12 14 Over a 24 Hour Period 18 Clean & disinfect Level of Bioburden on Product Surface Effect of Disinfection 16 18 20 22 24
Average bioburden wo/ cleaning Average Bioburden w/antimicrobial 0 2 4 6 8 10 12 14 Over a 24 Hour Period 19 Additional “dirt” Level of Bioburden on Product Surface Effect of Antimicrobial Treatment 16 18 20 22 24
Level of Bioburden on Product Surface Antimicrobial Treatment vs. Disinfection Average Bioburden w/o cleaning Average Bioburden – w/ Disinfectants Average Bioburden w/ Antimicrobials 0 2 4 6 8 10 12 14 16 Over a 24 Hour Period Disinfectants Microban® Antimicrobial Technology 20 18 20 22 24
Microban Efficacy Demonstration Unprotected Surface 2 hours 16 hours 20 hours 24 hours Surface with Microban® Antimicrobial Protection 2 hours 16 hours This information is based upon standard laboratory tests and is provided for comparative purposes to substantiate antimicrobial activity for non-public health applications. Microban technology is not designed to replace good hygiene practices or protect users from disease causing microorganisms. Antimicrobial action limited to product surface. 21
Antibacterial Test Methods Qualitative Test Method • 3 main methods covering bacterial and Fungal resistance. – AATCC TM 30 pt III (plastics materials – Fungal growth) – AATCC TM 147 (bacterial test method mainly for textile materials) – Kirby Bauer / Zone Diffusion (plastics materials – bacterial growth) • Results expressed as a Zone of Inhibition or measurement of inhibition area (mm). • Observations are also noted for Surface growth (fungal tests) and graded according to % coverage • Qualitative test methods show a product is able to inhibit the growth of the test organism (bacteriostatic or fungistatic activity)
Antibacterial Test Method Summary Quantitative Test Method • Two main standards employed : – ISO 22196 / JIS Z 2801 (Japanese Industrial standard) – AATCC TM 100 • Results expressed as a % reduction value and Log Kill e. g. 99. 9% = 3 Log reduction after recovery of viable organisms following a 24 hr period. – Samples results are expressed verses the initial population of bacteria or verses untreated control (when available) • Quantitative test methods show a product is able to actively kill the test organism (bactericidal or fungicidal activity) – Results obtained will also distinguish between bacteriostatic and bactericidal activity.
Antibacterial Microban Actives: Mode of Action Cationic Antimicrobials Zinc Pyrithione Based Metal ions CHLOROPHENOXY ANTIMICROBIALS • Antimicrobials ions Disrupts ion transport Copper or Silver gradientsnormal the (-SH) Disrupts across • combineroutes ion cell Multiple with the thiol membrane interfering groups in gradients, with transport amino acids and • Combine with catalysis cellular respiration disrupt enzymenutrient interfering with protein/enzyme amino and function and enzymatic • intakeand disrupt the React with energy acids production. Metal ions in functional groups cellular functions the cell are chelated and transported out of the cell • Disrupt cell membrane integrity causing loss of ion transport gradients • Triclosan blocks lipid biosynthesis and prevents formation of vital membrane fatty acids
Claims Overview • Claims will be developed based on laboratory substantiation of bacteriostatic/bacterocidal and/or fungistatic/fungicidal efficacy. • In addition, claims will be formulated based on one or more of the following key functional benefits provided by Microban protection. – Invisible Cleanliness – Visible Cleanliness – Odour Control – Product Degradation • Microban antimicrobial technologies are designed to provide durable antimicrobial protection. Lifetime durability claims may be used with the appropriate substantiating data.
Case Study: Cosentino® The makers of Silestone® countertops embraced Microban protection to differentiate their product from other quartz surfaces and to steal share from other countertop surface materials. Primary Objective • To differentiate Silestone® from granite and other countertop materials to generate demand justify premium price. Actions • Launched worldwide across their entire product line and supported with heavy media (T. V. advertising at prime time on Spanish and Portuguese channels) and pan European consumer print campaigns. • Sponsorship of Fernando Alonso Formula One driver supported by TV advertising on Spanish and Portuguese channels. Results • • 26 Major growth across Europe leading to 9 new sales offices and 3 distribution warehouses opening. Extension of product diversity from kitchen countertops to public space interior design.
Application example: Hospital Design Infection risk control – protecting buildings • 1. Walls • 2. Beds and curtains • 3. Blinds • 4. High contact surfaces • 5. Flooring • 6. Switches and controls • 7. Wet environments • 8. Computer equipment and reception areas
Case Study: WHIRLPOOL® Whirlpool embraced Microban to enhance their appliances features and is currently broadening the range of treated components across the product Primary Objective • To enhance Whirlpool appliances with a range of antibacterial features. Action • Whirlpool have introduced a special air filter device in the refrigerators which incorporates Microban antibacterial technology. • Following its success, the Microban technology has been extended to additional areas within the refrigeration project and also across the product mix (dishwashers and washing machines) within the Whirlpool and Bauknecht brands. Results • Significant differentiation achieved and communicated to Whirlpool customers. • Market surveys showing a remarkably high percentage of Whirlpool customers find the treatment appealing and innovative.
MICROBAN SUPPORT 29
The Microban Solution Microban provides a turnkey, ingredient branding solution, that ranges from a technical solution through the use of the Microban brand. 30
Technical Support Microban provides industry-leading technical services to ensure that partners get a customised technical solution that best meets their unique product. • Expert research and development – dedicated staff of engineers, microbiologists and analytical chemists. • The only antimicrobial solutions provider that offers over 20 different antimicrobial technologies under a single umbrella brand. • One of the most advanced antibacterial laboratories in the world. • Bacterial and fungal microbiology laboratories on -site at HQ in North Carolina. • Capacity to manage all of our partners’ testing needs. Microban micro lab completes over 30, 000 tests annually. • Close liaison with independent testing laboratories across Europe. • Privileged to be conducting cutting edge antimicrobial product development for the US Department of Defence.
HEALTHCARE RESEARCH 32
Healthcare Research 97% of healthcare professionals are concerned about the presence of microbes (such as bacteria, mold and mildew) in their healthcare facilities.
Healthcare Research 79% of patients are concerned about the presence of bacteria when at a hospital.
Patient room products / medical devices From initial patient and healthcare provider research Microban has identified key areas of contamination within patient rooms This research is being supported by a patient room swab study within Presbyterian Hospital Huntersville, USA to confirm highly contaminated products - “hot spots” Microban is currently in dialogue with manufacturers of ‘hot spot’ products and more than half have expressed a high level of interest in engaging with Microban on a project 35
Patent Protection With one of the strongest antimicrobial patent positions in the world, Microban helps its partners create competitive barriers where possible. • • In-house patent attorney surveys patent landscape at the outset of the project to determine areas of opportunity for patent protection. • Protects our partners from infringing on 3 rd party’s rights as well. • 36 163 patent applications and 42 issued patents protecting the use of Microban® antimicrobials in various end products help provide effective barriers to entry by your competitors. Proactive patent stance enables us to preserve our partner’s exclusivity and provide market leverage.
Regulatory Support Microban regulatory helps partners quickly secure the necessary approvals to hasten product launches, and ensures aggressive claim compliance. • • Former EPA Director is a member of the Microban Board who provides on -going advice. • Washington & Brussels – based regulatory consulting / law firms support Microban and its partners on a regular basis. • Experience working with international regulatory authorities to ensure compliance on a global basis. • US - EPA, FDA - EU - ECHA • Canada – PMRA - Australia - AVMPA • Mexico – Cicoplafest - UK – HSE • 37 In-house VP, Regulatory Affairs with over 20 years of regulatory and toxicology experience provides partners with unmatched expertise. Facilitate third part approvals with agencies such as NSF and TUV.
MARKETING SUPPORT 38
Microban Marketing Support • Claims Development • Packaging Development • Microban Website • Point of Sale Development • Microban Collateral • Market Research • Customer Specific Programmes • Press Releases 39 • Sales Training • Website Development
Microban Partner Advertising 40
Healthcare microsite www. microban. com/partnersites/microban-medical
Microban website World-wide coverage with direct link to partner website
Microban support literature Generic, customized and multilingual – designed for events, press packs and trade shows 43
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