Vitamins Ass. prof., Ph.D. Eugeniy V. Khomutov General

General By the end of XIX century it was known: Nevertheless the

Metabolism and functions blood cell transport Vit. Vit. Coenzyme Regulators, protectors (A, D, E,

Vitamin B1 В1 (Thiamine) Formation of active form 2АТP 2АДP

Витамин B1 Biological role: Oxidative decarboxylation of pyruvate pyruvate

Vit. B2 В2 (Riboflavine) B2 has 2 coenzyme forms: FMN и FAD

Vitamon B2 Biological role: Transfer of hydrogen atoms Desorder: Dermatitis

Vit. B3 В3 or РР (Niacin) 2 coenzyme forms: NAD+

Biological role: Hydrogen atoms transfer NAD+ + SH2 NAD·H + S

Биологическая роль: Витамин B5 Перенос ацильных групп (Цикл Кребса, обмен ВЖК и пр.) Заболевание:

Vit. Bc Вc (Folic acid) Coenzyme form: Tetrahydrofolic acid (THFA)

Vit. Bc Biological role: Переносчик одноуглеродных фрагментов: Main source of 1-С units -

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>Vitamins Ass. prof., Ph.D. Eugeniy V. Khomutov Vitamins Ass. prof., Ph.D. Eugeniy V. Khomutov

>General By the end of XIX century it was known: Nevertheless the General By the end of XIX century it was known: Nevertheless the specific disorders (beri-beri, scurvy, pellagrs etc.) were developing 1911 Funk obtained the substance that prevent beriberi from brane of rice and gave it’s the name - Vitamin (vita – life) 5th element

>Metabolism and functions blood cell transport Vit. Vit. Coenzyme Regulators, protectors (A, D, E, Metabolism and functions blood cell transport Vit. Vit. Coenzyme Regulators, protectors (A, D, E, K) modification The two main functions: Serve as the coenzyme for the composite enzymes Serve as regulators (D, A), protectors (A, E) and other specific functions (vision) Active form

>Vitamin B1 В1 (Thiamine) Formation of active form 2АТP 2АДP Vitamin B1 В1 (Thiamine) Formation of active form 2АТP 2АДP Thiamin В1 Thiamine pyrophosphate (TPP)

>Витамин B1 Biological role: Oxidative decarboxylation of pyruvate pyruvate Витамин B1 Biological role: Oxidative decarboxylation of pyruvate pyruvate Acetyl-CoA (Metabolism of CH and energy) α-ketoglutarate Succinyl-CoA (Metabolism of energy) Interconversions of pentoses (транскетолазная реакция)

>Vit. B2 В2 (Riboflavine) B2 has 2 coenzyme forms: FMN и FAD Vit. B2 В2 (Riboflavine) B2 has 2 coenzyme forms: FMN и FAD

>Vitamon B2 Biological role: Transfer of hydrogen atoms Desorder: Dermatitis Vitamon B2 Biological role: Transfer of hydrogen atoms Desorder: Dermatitis stomatitis, glossitis angular stomatitis Seborrhea FАD + SH2 FАD·H2 + S FМН + NADH2 ФМD·H2 + NAD+

>Vit. B3 В3 or РР (Niacin) 2 coenzyme forms: NAD+ Vit. B3 В3 or РР (Niacin) 2 coenzyme forms: NAD+ NADP+

>Biological role: Hydrogen atoms transfer NAD+ + SH2 NAD·H + S Biological role: Hydrogen atoms transfer NAD+ + SH2 NAD·H + S NADP+ + SH2 NADP·H + S Витамин B3 Desorder : pellagra (3 «D») Dermatitis of the exposed to sunlight sites of skin Dementia Diarrhea

>Биологическая роль: Витамин B5 Перенос ацильных групп (Цикл Кребса, обмен ВЖК и пр.) Заболевание: Биологическая роль: Витамин B5 Перенос ацильных групп (Цикл Кребса, обмен ВЖК и пр.) Заболевание: Понос Дерматит Остановка роста Поседение шерсти, аллопеция Повреждение нервной ткани, почек, надпочечников, сердца Pantos!!!

>Vit. Bc Вc (Folic acid) Coenzyme form: Tetrahydrofolic acid (THFA) Vit. Bc Вc (Folic acid) Coenzyme form: Tetrahydrofolic acid (THFA)

>Vit. Bc Biological role: Переносчик одноуглеродных фрагментов: Main source of 1-С units - Vit. Bc Biological role: Переносчик одноуглеродных фрагментов: Main source of 1-С units - serine Serine Glycine THFA Methylene-THFA Methyl-THFA Homocystin Methionine В12 Purine nucleotide dТМФ