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THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: TWENTY-FIFTH ANNUAL REPORT THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: TWENTY-FIFTH ANNUAL REPORT ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

MAJOR CONTRIBUTORS TO THE ISHLT TRANSPLANT REGISTRY Australia and New Zealand Cardiothoracic Organ Transplant MAJOR CONTRIBUTORS TO THE ISHLT TRANSPLANT REGISTRY Australia and New Zealand Cardiothoracic Organ Transplant Registry (ANZCOTR): Australia Eurotransplant (ET): Austria Germany Belgium Slovenia Netherlands Scandiatransplant: Denmark Finland Norway Sweden United Kingdom Transplant Services Authority (UKTSSA): United Kingdom Ireland United Network for Organ Sharing (UNOS): United States In addition, 85 individual centers from North America, Central/South America, Europe, Asia, and the Middle East have reported at least one transplant since 1995. ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible. ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

REGISTRY STEERING COMMITTEE Marshall Hertz – Medical Director Jason Christie – Associate Dir. for REGISTRY STEERING COMMITTEE Marshall Hertz – Medical Director Jason Christie – Associate Dir. for Lung Transplantation David O. Taylor – Associate Dir. for Heart Transplantation Richard Kirk – Associate Dir. for Pediatric Heart Transplantation Paul Aurora – Associate Dir. for Pediatric Lung Transplantation Axel Rahmel – Associate Dir. for OEO and Transplant Center Relations Fabienne Dobbels - Associate Dir. for Outcomes Analysis Amanda Rowe – ISHLT Executive Director Leah Edwards – Associate Dir. for Data Analysis ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

General Registry Statistics ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983 General Registry Statistics ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

REGISTRY DATABASE: Number of Transplants Reported Heart-Lung ISHLT 80, 106 63 3, 341 2, REGISTRY DATABASE: Number of Transplants Reported Heart-Lung ISHLT 80, 106 63 3, 341 2, 099 Heart Total Transplants Reported through 6/30/2007 3, 114 ORGAN Transplants Reported from 7/1/2006 through 6/30/2007 25, 950 2008 J Heart Lung Transplant 2008; 27: 937 -983

REGISTRY DATABASE: Number of Centers Reporting Transplants in between 1/2006 1996 and 6/2007 Organ REGISTRY DATABASE: Number of Centers Reporting Transplants in between 1/2006 1996 and 6/2007 Organ Centers Ever Reporting Data Heart 354 243 204 Heart-Lung 144 51 38 Lung 212 129 108 ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

REGISTRY DATABASE: Number of Centers Reporting Heart Transplants ISHLT 2008 J Heart Lung Transplant REGISTRY DATABASE: Number of Centers Reporting Heart Transplants ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

REGISTRY DATABASE: Number of Centers Reporting Lung Transplants ISHLT 2008 J Heart Lung Transplant REGISTRY DATABASE: Number of Centers Reporting Lung Transplants ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

REGISTRY DATABASE: Number of Centers Reporting Heart-Lung Transplants ISHLT 2008 J Heart Lung Transplant REGISTRY DATABASE: Number of Centers Reporting Heart-Lung Transplants ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

APPENDIX ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983 APPENDIX ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center ARGENTINA Fundacion Favaloro x Hospital Italiano x AUSTRALIA 1 St. Vincent x Royal Children x The Prince Charles Hospital x The Alfred Hospital x Royal Perth Hospital x AUSTRIA 2 Allgemeines Krankenhaus Wien x Universitätsklinik Innsbruck x Landeskrankenhaus Graz x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center BELGIUM 2 Hôpital Erasme Bruxelles x Universitair Ziekenhuis Antwerpen x Onze Lieve Vrouw Ziekenhuis Aalst x Universitair Ziekenhuis Gent x Centre Hospitalier Universitaire Liège x Cliniques Universitaires, Université Catholique de Louvain x UZ Gasthuisberg Leuven x BRAZIL Heart Institute-Univ. Sao Paulo Hospital das Clinicas x Hospital de Messejana x CANADA Royal Victoria Hospital ISHLT x (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center CANADA (cont’d) Montreal Heart Institute x The Toronto General Hospital x Hospital Notre-Dame x Quebec Heart Institute - Laval Hospital x Ottawa Heart Institute x Health Sciences Centre x University of Alberta Hospitals/Walter C. Mackenzie Health Sciences x The Hospital For Sick Children x CHILE Hospital Gustavo Fricke x COLOMBIA Cliniica Cardiovascular ISHLT x (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center DENMARK 3 Skejby University Hospital x FINLAND 3 Helsinki University Central Hospital x Children's Hospital, Univ. of Helsinki x GERMANY 2 Universität des Saarlandes Homburg/Saar x Martin-Luther-Universität Halle x Herzzentrum Dresden Gmb. H x Deutsches Herzzentrum Berlin x Universität Leipzig - Herzzentrum x Klinikum der Universität Regensburg x Herzzentrum Nordrhein-Westfalen Bad Oeynhausen x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center GERMANY 2 (cont’d) Universitätsklinikum Essen x Universitätsklinikum Münster x Ruprecht-Karls-Universität Heidelberg x Medizinische Hochschule Hannover x Universitätsklinikum Aachen x Klinikum Fulda x Klinikum der Justus-Liebig-Universität Giessen x Universitätsklinikum Schleswig-Holstein Kiel x Johann Wolfgang Goethe Universität Frankfurt/Main x Friedrich Schiller Universität Jena x Friedrich Alexander Universität Erlangen x Ludwig Maximilians Universität München x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center GERMANY 2 (cont’d) Deutsches Herzzentrum München x Universitätsklinikum Hamburg x Klinikum der Albert-Ludwigs-Universität Freiburg im Breisgau x GREECE Onassis Cardiac Surgery Center x IRELAND 4 Mater Hospital x ISRAEL Rabin Medical Center (Belinson Campus) x Sheba Medical Center x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center ITALY Niguarda CA Granda Hospital x Policlinico S. Orsola - Universita degli Studi x JAPAN Tohoku University Hospital x Kyoto University Hospital x Saitama Medical School Hospital x KOREA Yongdong Severance Hospital x NETHERLANDS 2 Universitair Medisch Centrum Utrecht x Erasmus Medisch Centrum Rotterdam x Universitair Medisch Centrum Groningen x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center NEW ZEALAND Green Lane Hospital x NORWAY 3 Rikshospitalet - National Hospital of Norway x SPAIN Hospital Clinic x Hospital Central DE Asturias x SWEDEN 3 Sahlgrenska University Hospital x University Hospital of Lund x TAIWAN Cheng-Hsin General Hospital ISHLT x (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED KINGDOM 4 Great Ormand Street Hospital for Children x University of Glasgow/Glasgow Royal Infirmary x The Freeman Hospital x Harefield Hosp x Wythenshawe Hospital x Queen Elizabeth Hospital x Papworth Hospital x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 Univ. of Alabama Hospital, Birmingham, AL x Baptist Medical Center, Little Rock, AR x Arkansas Childrens Hospital, Little Rock, AR x The Univ. Hosp of Arkansas, Little Rock, AR x Mayo Clinic Hospital, Phoenix, AZ x St Josephs Hosp and Med Ctr, Phoenix, AZ x University Medical Ctr, Univ. of AZ, Tucson, AZ x Childrens Hospital Los Angeles, CA x Cedars-Sinai Med Center, Los Angeles, CA x Loma Linda Univ. Med Ctr, Loma Linda, CA x California Pacific Med Ctr, San Francisco, CA x UCSD Medical Center, San Diego, CA x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Univ. of CA San Francisco Med Ctr, San Francisco, CA x Sutter Memorial Hospital, Sacramento, CA x Sharp Memorial Hospital, San Diego, CA x Stanford Univ. Med Ctr, Stanford, CA x St. Vincent Medical Center, Los Angeles, CA x UCLA Medical Center, Los Angeles, CA x USC University Hospital, Los Angeles, CA x The Children's Hospital, Aurora, CO x University of Colorado Hospital/HSC, Aurora, CO x Hartford Hospital, Hartford, CT x Yale New Haven Hosp, New Haven, CT x Children's Natl Medical Ctr, Washington, DC x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/2006 -6/2007 and Reported to Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/2006 -6/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Washington Hospital Center, Washington, DC x Alfred I du. Pont Hospital for Children, Wilmington, DE x All Childrens Hospital, St. Petersburg, FL x Jackson Memorial Hosp, Miami, FL x St. Luke's Hospital, Jacksonville, FL x Tampa General Hospital, Tampa, FL x Shands Hosp at Univ. of FL, Gainesville, FL x Children's Healthcare of Atlanta, GA x Emory Univ. Hospital, Atlanta, GA x St. Joseph's Hosp of Atlanta, GA x Hawaii Medical Center – East, Honolulu, HI x Univ. of Iowa Hosp and Clinics, Iowa City, IA x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/2006 -6/2007 and Reported to Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/2006 -6/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Children's Memorial Hospital, Chicago, IL x Loyola Univ. Med Center, Maywood, IL x Northwestern Memorial Hospital, Chicago, IL x Rush University Med Ctr, Chicago, IL x OSF St Francis Med Ctr, Peoria, IL x Univ. of Chicago Med Ctr, Chicago, IL x Clarian Health-Methodist/IU/Riley, Indianapolis, IN x Lutheran Hosp of Ft Wayne, IN x St Vincent Hosp and Health Care Ctr, Indianapolis, IN x Via Christi Reg Med Center, Wichita, KS x Jewish Hospital, Louisville, KY x Kosair Childrens Hosp, Louisville, KY x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Univ. of Kentucky Med Ctr, Lexington, KY x Ochsner Foundation Hospital, New Orleans, LA x Tulane Univ. Medical Center, New Orleans, LA x Children's Hospital Boston, MA x Massachusetts General Hospital, Boston, MA x Tufts Medical Center, Boston, MA x Brigham and Womens Hosp, Boston, MA x Johns Hopkins Hospital, Baltimore, MD x Univ. of Maryland Med System, Baltimore, MD x Children's Hosp of Michigan, Detroit, MI x Henry Ford Hospital, Detroit, MI x Univ. of Michigan Med Ctr, Ann Arbor, MI x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Abbott Northwestern Hospital, Minneapolis, MN x St Marys Hospital (Mayo Clinic), Rochester, MN x Univ. of Minnesota Medical Center, Minneapolis, MN x Barnes-Jewish Hospital, St. Louis, MO x Cardinal Glennon Childrens Hosp, St. Louis, MO x St. Louis Children's Hospital, St Louis, MO x St Lukes Hosp of Kansas City, MO x St. Louis University Hospital, St Louis, MO x Univ. of MS Med Ctr, Jackson, MS x NC Baptist Hospital, Winston Salem, NC x Carolinas Med Ctr, Charlotte, NC x Duke University Medical Center, Durham, NC x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) UNC Hospitals, Chapel Hill, NC x Bryan. LGH Medical Center East, Lincoln, NE x The Nebraska Medical Center, Omaha, NE x Newark Beth Israel Med Ctr, Newark, NJ x Robert Wood Johnson University Hosp, New Brunswick, NJ x Albany Med Center Hospital, Albany, NY x The Presbyterian Hosp in NY City, New York, NY x Strong Memorial Hospital, Rochester, NY x Montefiore Medical Center, Bronx, NY x Mount Sinai Med Center, New York, NY x Westchester Medical Center, Valhalla, NY x Cleveland Clinic Foundation, Cleveland, OH x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Nationwide Children's Hospital, Columbus, OH x Children's Hosp Med Ctr, Cincinnati, OH x Ohio State Univ. Med Ctr, Columbus, OH x Univ. of Cincinnati Medical Center, Cincinnati, OH x Providence Portland Medical Center, Portland, OR x Oregon Health and Science University, Portland, OR x Allegheny General Hosp, Pittsburgh, PA x Children's Hospital of Pittsburgh, PA x Childrens Hosp of Philadelphia, PA x Penn State Milton S Hershey Med Ctr, Hershey, PA x Hahnemann University Hospital, Philadelphia, PA x The Lankenau Hospital, Wynnewood, PA x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Univ. of Pittsburgh Med Ctr, Pittsburgh, PA x Thomas Jefferson Univ. Hosp, Philadelphia, PA x Temple Univ. Hospital, Philadelphia, PA x The Hosp of the Univ. of PA, Philadelphia, PA x Baptist Memorial Hosp, Memphis, TN x St. Thomas Hospital, Nashville, TN x Vanderbilt Univ. Med Ctr, Nashville, TN x University Hospital, San Antonio, TX x Children's Med Ctr of Dallas, TX x Seton Medical Center, Austin, TX x Medical City Dallas Hospital, Dallas, TX x St Luke's Episcopal Hospital, Houston, TX x ISHLT (Cont’d) 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/2005 -6/2005 and Reported to Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/2005 -6/2005 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Methodist Specialty & Transplant Hosp, San Antonio, TX x Univ. of Texas Med Branch, Galveston, TX x The Methodist Hospital, Houston, TX x Christus Santa Rosa Medical Center, San Antonio, TX x Cardiovascular Ctr of PR, San Juan, PR x University Hosp of Cleveland, OH x Integris Baptist Med Ctr, Oklahoma City, OK x Saint Francis Hospital, Tulsa, OK x Medical Univ. of SC, Charleston, SC x University Hospital - St. Paul, Dallas, TX x Texas Children's Hospital, Houston, TX x Baylor University Medical Center, Dallas, TX x (Cont’d) ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Intermountain Medical Center, Murray, UT x Univ. of Utah Medical Center, Salt Lake City, UT x Primary Childrens Med Ctr, Salt Lake City, UT x Inova Fairfax Hosp, Falls Church, VA x Henrico Doctors' Hospital, Richmond, VA x MCV Hospitals, Richmond, VA x Mc. Guire VA Medical Center, Richmond, VA x Sentara Norfolk General Hospital, Norfolk, VA x Univ. of Virginia HSC, Charlottesville, VA x Children's Hosp & Reg Medical Center, Seattle, WA x Sacred Heart Med Ctr, Spokane, WA x Univ. of Washington Med Ctr, Seattle, WA x ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983

Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT Centers Reporting to the ISHLT Transplant Registry TXs Performed 1/20066/2007 and Reported to ISHLT COUNTRY/Center UNITED STATES 5 (cont’d) Childrens Hosp of Wisconsin, Milwaukee, WI x Froedtert Mem Lutheran Hosp, Milwaukee, WI x Aurora St. Luke's Medical Center, Milwaukee, WI x Univ. of Wisconsin Hosp and Clinics, Madison, WI x Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCOTR) Data provided via Eurotransplant 3 Data provided via Scandiatransplant 4 Data provided via United Kingdom Transplant Support Service Authority (UKTSSA) 5 Data provided via United Network for Organ Sharing (UNOS) 1 2 ISHLT 2008 J Heart Lung Transplant 2008; 27: 937 -983