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Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012) Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize preprint. Food and Chemical Toxicology, ---, pp --www. elsevier. com/locate/foodchemtox AND http: //dx. doi. org/10. 1016/j. fct. 2012. 08. 005 AND http: //www. askforce. org/web/Seralini-Long-Term-Toxicity-RR-2012. pdf AND http: //www. ask-force. org/web/Seralini-Press-Sustainable-Trust-20120919. pdf

Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012) Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize preprint. Food and Chemical Toxicology, ---, pp --www. elsevier. com/locate/foodchemtox AND http: //dx. doi. org/10. 1016/j. fct. 2012. 08. 005 AND http: //www. askforce. org/web/Seralini-Long-Term-Toxicity-RR-2012. pdf AND http: //www. ask-force. org/web/Seralini-Press-Sustainable-Trust-20120919. pdf

Seralini’s research and the way it is published raise serious ethical questions. As pointed Seralini’s research and the way it is published raise serious ethical questions. As pointed out by antivivisection groups, this poorlyconducted and cruel experiment causing suffering for no meaningful scientific purpose is unacceptable. http: //www. buav. org/article/1112. Despite the flaws in the research, Séralini et al widely publicised their unsubstantiated conclusions in an unscientific and scaremongering campaign with anti -biotech groups and some politicians.

The wrong use of rats: Sprague-Dewey Rats are highly prone to spontaneous tumors even The wrong use of rats: Sprague-Dewey Rats are highly prone to spontaneous tumors even more when fed ad libitum as recommended by Séralini

Demonstrates the systemic mistakes in results you get when using Sprague. Dawley rats Eldridge, Demonstrates the systemic mistakes in results you get when using Sprague. Dawley rats Eldridge, J. C. , Wetzel, L. T. , Stevens, J. T. , & Simpkins, J. W. (1999) The mammary tumor response in triazine-treated female rats: A threshold-mediated interaction with strain and species-specific reproductive senescence. Steroids, 64, 9, pp 672 -678 http: //www. ask-force. org/web/Seralini/Eldridge-Mammary-Tumor-Sprague-F 344 -1999. pdf

Reduced caloric intake reduces tumor incidence Limiting the number of calories reduces tumor incidence. Reduced caloric intake reduces tumor incidence Limiting the number of calories reduces tumor incidence. Seralini allowed rat feeding ad libitum (no restriction) Slide by K. Ammann Ross, M. H. & Bras, G. (1965) TUMOR INCIDENCE PATTERNS AND NUTRITION IN RAT. Journal of Nutrition, 87, 3, pp 245 -& : //WOS: A 19656943000001 AND http: //www. ask-force. org/web/Seralini/Ross-Tumor-Incidence-Patterns-Nutrition-1965. pdf

Figure 2 Adjusted survival curves for male rats (top panel) and female rats (bottom Figure 2 Adjusted survival curves for male rats (top panel) and female rats (bottom panel) in the 2 -year carcinogenicity study with nelfinavir. Burns-Naas, L. A. , Zorbas, M. , Jessen, B. , Evering, W. , Stevens, G. , Ivett, J. L. , Ryan, T. E. , Cook, J. C. , Capen, C. C. , Chen, M. , Furman, G. , Theiss, J. C. , Webber, S. , Wu, E. , Shetty, B. , Gasser, R. , & Mc. Clain, R. M. (2005) Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2 -year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia. Human & Experimental Toxicology, http: //www. askforce. org/web/Seralini/Burns-Naas. Increase-thyroid-2005. pdf

Durbin, P. W. , Williams, M. H. , Jeung, N. , & Arnold, J. Durbin, P. W. , Williams, M. H. , Jeung, N. , & Arnold, J. S. (1966) DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS OVER LIFE-SPAN OF FEMALE CHARLES RIVER (SPRAGUE-DAWLEY) RAT - INFLUENCE OF OVARIECTOMY THYROIDECTOMY AND ADRENALECTOMY-OVARIECTOMY. Cancer Research, 26, 3 P 1, pp 400 -& http: //www. ask-force. org/web/Seralini/Durbin-Development-Spontaneous-Mammary-Tumors-1966. pdf

Durbin, P. W. , Williams, M. H. , Jeung, N. , & Arnold, J. Durbin, P. W. , Williams, M. H. , Jeung, N. , & Arnold, J. S. (1966) DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS OVER LIFESPAN OF FEMALE CHARLES RIVER (SPRAGUE-DAWLEY) RAT INFLUENCE OF OVARIECTOMY THYROIDECTOMY AND ADRENALECTOMY-OVARIECTOMY. Cancer Research, 26, 3 P 1, pp 400 -& http: //www. askforce. org/web/Seralini/Durbin. Development-Spontaneous. Mammary-Tumors-1966. pdf

Sprague–Dawley rats were used briefly by the NCI both in exploratory projects and some Sprague–Dawley rats were used briefly by the NCI both in exploratory projects and some early carcinogenicity bioassays, but the ‘‘large size and. numerous spontaneous tumors in this strain’’ were considered detrimental characteristics compared to perceived advantages with F 344 rats Weisburger, J. H. , Williams, G. M. , 1981. Carcinogen testing: current problems and new approaches. Science 214, 401– 407 Hayes Wallace A. , Dayan, A. D. , Hall, W. C. , Kodell, R. L. , Williams, G. M. , Waddell, W. D. , Slesinski, R. S. , & Kruger, C. L. (2011) A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients. Regulatory Toxicology and Pharmacology, 60, 1, Supplement, pp S 1 -S 34 http: //www. sciencedirect. com/science/article/pii/S 0273230010001819 AND http: //www. ask-force. org/web/Seralini/Hayes. Review-Mammalian-Carcinogenicity-Study-Design-2011. pdf

EFSA-Statement (20121004) Review of the Séralini et al. (2012) publication on a 2 -year EFSA-Statement (20121004) Review of the Séralini et al. (2012) publication on a 2 -year rodent feeding study with glyphosate formulations and GM maize NK 603 as published online on 19 September 2012 in Food and Chemical Toxicology EFSA Journal, 2012; 10(10): 2910 pp 1 -9 Press release: http: //www. efsa. europa. eu/en/press/news/121004. htm AND Assessment: http: //www. efsa. europa. eu/en/efsajournal/doc/2910. pdf AND EFSA-Letter to Seralini: http: //www. efsa. europa. eu/en/edinterviews/docs/corporate. Seralini 121004. pdf AND http: //www. ask-force. org/web/Regulation/EFSA. Statement-Seralini-Journal-201210 -10 -2912 -20121004. pdf

Fundamental flaws of the Seralini research and reporting. As EFSA concluded, the Seralini study Fundamental flaws of the Seralini research and reporting. As EFSA concluded, the Seralini study is “inadequately designed, analysed and reported. ” The research has several fundamental flaws, such as extending a 90 -day feeding trial to two years without adjusting the design of the study, and using this particular strain of rats – which spontaneous develops tumours – without using a statistically required number of those rats.

EFSA (20121011) Electronic Source: European Court of Auditors recognises EFSA’s advanced independence policy, makes EFSA (20121011) Electronic Source: European Court of Auditors recognises EFSA’s advanced independence policy, makes recommendations (ed EFSA European Food Safety Authority) http: //www. efsa. europa. eu/en/press/news/121011. htm AND http: //www. ask-force. org/web/Seralini/EFSA-Cour-Autitors. Recommendations-20121011. pdf European Court of Auditors recognises EFSA’s advanced independence policy, makes recommendations The European Food Safety Authority (EFSA) is applying some of the most advanced policies and procedures for declaring, assessing and managing potential conflicts of interest, the European Court of Auditors said in a review of the management of conflicts of interests in four independent agencies of the European Union. The Court has made a number of recommendations, many of which are already integrated in EFSA’s working processes. EFSA will carefully examine any recommendations which may remain outstanding.

Pathologies 1. 4 Pathologies per animal in relation to the whole group 1. 2 Pathologies 1. 4 Pathologies per animal in relation to the whole group 1. 2 1 0. 8 0. 6 0. 4 0. 2 0 Mammary tumors Controll 11% 50 ng/L Mammary glands Hepato-digestive Liver tract Kidney 22% 33% GMO 1. Group, GMO + Glyphosate 2. Group 2, 3 g/L Glyphosate in trinking water 50 mg/L Prof. Dr. Klaus Jany, data from Euro/Biotech/News: 10, Vol. 11, 2012

Diet with conventional isogenic maize and water with Roundup In some cases the higher Diet with conventional isogenic maize and water with Roundup In some cases the higher dose with positive effects! Other examples of strange behavior (effect NOT proportional Effects of Roundupto the dose) alone: Roundup was administrated in drinking water at 3 increasing doses, same symbols (environmental (A), MRL in agricultural GMOs (B) and half of minimal agricultural levels (C), see Section 2).

All public authorities that examined Seralini’s study have rejected it, except ENSSER Many public All public authorities that examined Seralini’s study have rejected it, except ENSSER Many public authorities, including the European Food Safety Authority (EFSA), the German Federal Institute for Risk Assessment and the French Haut Conseil des Biotechnologies, have reviewed the study and all come to a similar conclusion: the research of Séralini et al was so flawed that the conclusions have no basis. The reviews of these authorities can be found on: http: //www. prri. net/qa-seralini-et-al-2012/ 37 official units published rebuttals

Over 35 Agencies have written contradictions Australia & New Zealand – Food Standards (FSANZ) Over 35 Agencies have written contradictions Australia & New Zealand – Food Standards (FSANZ) – (link) Belgium – Biosafety Council – (link) Brazil – Nat. Techn. Commission on Biosafety (CTNBio) – (link) Canada – Health Canada, Food Inspection Agency – (link) Denmark – National Food Institute – (link) EFSA – European Food Safety Authority (EFSA) – (link) France – High Council of Biotechnologies (HCB) – (link) France – National Sanitary Safety Agency (ANSES) – (link) Germany – Federal Institute for Risk Assessment (Bf. R) – (link) Netherlands – Food and goods authority (VWA) – (link) Romania – Food Safety Authority (ANSVSA) – (link)

Bf. R-Bund (20120928) Veröffentlichung von Seralini et al. zu einer Fütterungsstudie an Ratten mit Bf. R-Bund (20120928) Veröffentlichung von Seralini et al. zu einer Fütterungsstudie an Ratten mit gentechnischverändertem Mais NK 603 sowie einer glyphosathaltigen Formulie-rung (eds BUND), pp. 8. German Government, Berlin, Germany http: //www. bfr. bund. de/de/presseinformation/2012/29/studie_der_unive rsitaet_caen_ist_kein_anlass_fuer_eine_neube_wertung_von_glyphos at_und_gentechnisch_veraendertem_mais_nk_603 -131728. html AND http: //www. ask-force. org/web/Seralini/Bf. R-bund-Stellungsnahme. Seralini-20120928. pdf AND http: //www. bfr. bund. de/cm/343/veroeffentlichung-von-seralini-et-al-zueiner-fuetterungsstudie-an-ratten-mit-gentechnischveraendertem-maisnk 603 -sowie-einer-glyphosathaltigen-formulierung. pdf AND English http: //www. ask-force. org/web/Seralini/Bf. R-bund-Position-engl-Seralini 20121001. pdf The authors conclusions that rats fed with GM Nk 603 maize throughout their life have shorter life span is not sufficiently corroborated by experiments

These studies have shown that old Harlan Sprague-Dawley rats get cancers and other diseases. These studies have shown that old Harlan Sprague-Dawley rats get cancers and other diseases. What this study of Séralini does not show is that exposing these rats to GM corn and/or Roundup makes any difference to the frequency of cancers or other diseases. It can’t because no statistical tests have been applied, and perhaps most worryingly, the authors do not comprehensively report on why rats in the control group died. And most unusually: the authors refuse explicitly to present the raw data Miller Henry I. & Chassy Bruce M. (20120925) Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http: //www. forbes. com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http: //www. ask-force. org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925. pdf

Ø– the investigators used a strain of rats that were bred to develop tumors Ø– the investigators used a strain of rats that were bred to develop tumors as they aged (a detail they failed to disclose). Significantly, mortality rates and tumor incidence in all experimental groups fall within historical norms for this strain of laboratory rats. Therefore, the claim that the genetically engineered corn component of the diet or the herbicide caused the tumors is insupportable. Ø– Séralini et al. argue that the exceedingly long time-frame of their study was necessary to reveal the experimental effects, but animal researchers long ago established that such lengthy studies add no additional meaningful or valid information beyond that which can be collected in shorter times; Ø– there is no documentation of the rats’ food intake, which strongly affects the incidence of tumors in this strain; Ø– the experiment included 180 rats (9 groups of 20) fed the genetically engineered or herbicide-containing diets (the “treated rats”), while only 20 rats were fed a standard (control) diet. Both common sense and a rudimentary understanding of statistics tell you that even if there were no actual differences between the groups, the greater numbers of animals in the pooled treated groups increases the odds that one of the treated rats would die first (one of the parameters reported in the paper); Miller Henry I. & Chassy Bruce M. (20120925) Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http: //www. forbes. com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http: //www. ask-force. org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925. pdf

Ø– the statistical methods employed were unconventional and appeared to be selected specifically in Ø– the statistical methods employed were unconventional and appeared to be selected specifically in order to give a certain result. Tom Sanders, head of the nutritional sciences research division at King’s College London, called the treatment of data “a statistical fishing trip”; Ø– absence of statistical analysis for mortality or tumor incidence. Statistical analysis is a basic requirement of scientific research, and given that the claims of the study allege tumor and mortality effects, the omission of statistical analysis is inexcusable; Ø– the investigators have refused to release all the data from the experiment, which constitutes scientific misconduct; Ø– insufficient information is provided about the source and quality of corn varieties used in the rats’ diet (contamination with molds could be a critical factor); Ø– absence of data concerning liver or kidney histopathology and liver function tests; Ø– insufficient explanation of the absence of a dose-response relationship between the experimental variables and supposed effects; Ø– inappropriate, unnecessary suffering of the rats, which should have been euthanized long before the tumors became so huge – an especially egregious ethics violation given that the study is, in any case, worthless. Ø– the reported results conflict with innumerable experiments conducted by laboratories around the world on both genetically engineered corn and glyphosate, and also with vast real-world experience. Miller Henry I. & Chassy Bruce M. (20120925) Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http: //www. forbes. com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http: //www. ask-force. org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925. pdf

Number of rats: Seralini’s manipulation: The OECD guidelines 451 (carcinogenicity studies) states clearly: 50 Number of rats: Seralini’s manipulation: The OECD guidelines 451 (carcinogenicity studies) states clearly: 50 rats. Séralini cites OECD guideline 452 (chronic toxicity studies), where it is stated: 20 rats per sex, per group, total at least 40 rats Seralini refers wrongly to OECD 452 and even citing it with wrong numbers, thus justifying his use of 10 rats. With just 10 rats, the results are heavily influenced by sampling, The study is flawed also in sampling OECD Guideline 451 (20090908) Test No. 451: Carcinogenicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects pp 15 http: //www. oecdbookshop. org/oecd/display. asp? lang=EN&sf 1=identifiers&st 1=5 lmqcr 2 k 7 mq 4 AND http: //www. ask-force. org/web/OECD-Carcinogenicity-Studies-Guideline-451 -20090907. pdf OECD Guideline 452 (20090908) OECD Test No. 452: Chronic Toxicity Studies OECD, IS: ISBN: 9789264071209 , OECD Code: 979945201 E 1 pp http: //www. oecdbookshop. org/oecd/display. asp? lang=EN&sf 1=identifiers&st 1=5 lmqcr 2 k 7 mlw AND http: //www. ask-force. org/web/OECD-Guideline-452 -adopted-Chronic-Toxicity-20090907. pdf

A collection of links of rebuttals coming in the first few days Keogh, B. A collection of links of rebuttals coming in the first few days Keogh, B. (2012) Biotech Crops Seal of Safety Does Not Convince Skeptics. Journal of the National Cancer Institute, pp http: //jnci. oxfordjournals. org/content/early/2012/03/22/jnci. djs 196. short AND http: //www. ask-force. org/web/Seralini/Keogh-Biotech-Crops-Seal-Safety-2012. pdf Koerth-Baker Maggie (20120921) Electronic Source: Authors of study linking GM corn with rat tumors manipulated media to prevent criticism of their work published by: http: //boingboing. net/2012/09/21/authors-of-study-linking-gm-co. html AND http: //www. ask-force. org/web/Seralini/Koerth-Baker-Authors-Manipulted-Media-20120921. pdf Morandini Piero (20120920) Letter to the Editor Prof. Hayes of Food and Chemical Toxicology, related to Seralini-Study. Food and Chemical Toxicology, --, pp -http: //www. ask-force. org/web/Seralini/Morandini-Letter-to-Editor 20120920. pdf Ng Ashley (20120925) Electronic Source: Genetically modified corn and cancer - what does the evidence really say? , The Conversation, Academic Rigour, Journalistic Flair https: //theconversation. edu. au/genetically-modified-corn-and-cancer-what-does-the-evidence-really-say-9746 Revkin Andrew C. (20120921) Electronic Source: Group Promoting Rat Study of Engineered Corn Forced Coverage Rush, published by: New York Times http: //dotearth. blogs. nytimes. com/2012/09/21/group-promoting-rat-study-of-engineered-corn-forced-coverage-rush/ AND http: //www. ask-force. org/web/Seralini/Revkin-Group-Promotion-Coverage-Rush-20120921. pdf Scientific-Alliance (20120921) Electronic Source: Legitimate fears over GM crops? , published by: The Scientific Alliance · St John's Innovation Centre · Cowley Road · Cambridge, Cambridgeshire CB 4 0 WS http: //us 2. campaign-archive 1. com/? u=f 1 e 3 eeb 023 e 7 d 88 eff 0 dda 8 a 2&id=2823730491&e=af 721 f 4 e 26 AND http: //www. ask-force. org/web/Seralini/Scientific-Alliance-Seralini-Newsletter-20120921. pdf Kuntz, M. (2011) Electronic Source: Seralini Critique: The latest opus of «parallel science » of Criigen from March 2011 (ed M. Kuntz), Parallel Science published by: Marcel Kuntz http: //ddata. over-blog. com/xxxyyy/1/39/38/37/Critical_views_on_Seralini_20110710. pdf Miller Henry I. & Chassy Bruce M. (20120925) Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http: //www. forbes. com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http: //www. ask-force. org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925. pdf

Comparison short-long term reveals chaotic Study Plan Comparison short-long term reveals chaotic Study Plan

Séralini‘s false claim that Monsanto study did not give in 2006 study the precise Séralini‘s false claim that Monsanto study did not give in 2006 study the precise amounts of test feeds Wrong, since Hammond referred explicitly to the previous Study from 2004 << fig. from 2004 study Hammond, B. , Dudek, R. , Lemen, J. , & Nemeth, M. (2004) Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn. Food and Chemical Toxicology, 42, 6, pp 10031014 http: //www. ask-force. org/web/Seralini/Hammond-Results-13 -week-safetyassurance-glyphosate-2004. pdf AND Certified Rodent diet 5002: http: //labdiet. com/pdf/5002. pdf Hammond, B. G. , Dudek, R. , Lemen, J. K. , & Nemeth, M. A. (2006) Results of a 90 -day safety assurance study with rats fed grain from corn borer-protected corn. Food and Chemical Toxicology, 44, 7, pp 10921099 http: //www. ask-force. org/web/Seralini/Hammond-Results-90 -day. MON 810 -2006. pdf

www. . alerte-environmnement. fr infographie www. . alerte-environmnement. fr infographie

14. January 2013 EFSA is today announcing the launch of a major initiative designed 14. January 2013 EFSA is today announcing the launch of a major initiative designed to facilitate access to data, enhancing transparency in risk assessment. The programme, to be developed in cooperation with the Authority’s partners and stakeholders, will consider how best and to what extent technical data used in risk assessments can be made available to the broader scientific community and interested parties.

The “dark side” of Professor Séralini Of the many people in the entourage of The “dark side” of Professor Séralini Of the many people in the entourage of Professor Gilles-Eric Séralini, there are his friends from Sevene Pharma, a discreet company owned by the leaders of a strange movement. Riviere-Wekstein, G. (201212) Decryptage La « part d’ombre » du professeur Séralini. ae, Agriculture et Environment, 109, pp 7 http: //www. ask-force. org/web/Seralini/Riviere-Gil-Seralini-partdelombre-2012. pdf AND http: //www. ask-force. org/web/Seralini/Riviere-Gressel-Dark-Side-Seralini-ae-Dec-2012. pdf

Seralini’s self proclaimed independence of research is a hoax. The main defence of Seralini Seralini’s self proclaimed independence of research is a hoax. The main defence of Seralini et al after the massive criticisms of their work was accusing those who criticised of not being independent, and proclaiming themselves as ‘independent’ This is a hoax. Apart from the widespread issued concerns about Seralini’s ties with companies, anti-biotech NGOs and politicians, we should remember that criticisms on the work of Seralini et al by individual scientists, academic establishments, research institutes, national bodies and EFSA are based onscience. As said by Olivier Godard, Research Director at the French public institute CNRS, during ahearing at the French National Assembly on 19 November 2012, “the right question to ask to ensure the independence of collective expertise is not ‘tell me to who you are linked to…’ but ‘what are the arguments that justify your viewpoint…. ’. ” Olenyi Sebastian (20120228) Electronic Source: GM crops: Forget the money, follow the science (ed S. Olenyi), published by: The BTS blog of the Biotechnology and Society group of the TU Delft and Euractiv http: //www. euractiv. com/cap/gm-crops-follow-money-analysis-510724#comment-2945 AND http: //www. ask-force. org/web/Fundamentalists/Olenyi-GM-Crops-Forget-Money-Follow-Science 20120228. pdf

www. . alerte-environmnement. fr infographie www. . alerte-environmnement. fr infographie

Authors’ contributions CG carried out the cellular, biochemical and molecular studies, participated in drafting Authors’ contributions CG carried out the cellular, biochemical and molecular studies, participated in drafting the manuscript. NB and EC reproduced and helped the cellular experiments. CT participated in the methodological and protocol advices, and discussions. FL initiated the collaboration in Sevene Pharma and carefully followed the first sets of experiments for the protocol design. CL participated in Dig 1 conception and discussions. CDL directed Dig 1 assessment for Sevene Pharma and GES conceived the study, the final version of the manuscript, participated in the design of the work and was responsible for the coordination. All authors read and approved the final manuscript. Competing interests Gasnier, C. , Benachour, N. , Clair, E. , Travert, C. , Langlois, F. , Laurant, C. , Decroix-Laporte, C. , & Seralini, G. -E. (2010) Dig 1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. Journal of occupational medicine and toxicology (London, England), 5, pp 29 -29 http: //www. ask-force. org/web/Seralini/Gasnier-Dig 1 -protects-against-celldeath-2010. pdf The authors declare that they have no competing interests. The development of Dig 1 in Sevene Pharma was performed completely independently of its assessment. The scientists in the University of Caen in charge of the assessment of xenobiotics or plant extracts declare no financial or other interests in the development of these products.

CRIIGEN’s website credits the Professor with being recently named the CRIIGEN’s website credits the Professor with being recently named the "International Scientist of the year 2011" in a bogus certificate awarded by the International Biographical Centre of Cambridge, England. The International Biographical Centre has nothing to do with Cambridge University. Edwards, I. B. & Beetles, C. (2012) Information about Australian Tour of G. E. Seralini in February 2012 Newspaper, Report and Fake Diploma, Stock & Land, pp (Stock & Land, Article) http: //www. ask-force. org/web/Seralini/Edwards-Beetles. Seralini-Information-Sheet-Australia-2012. pdf see comment in French by Marcel Kunzt: http: //www. agriculture-environnement. fr/a-laune, 6/seralini%E 2%80%89 -le-prix-de-l-ego, 771. html

http: //kruemelmonsterag. blogspot. com/2009/05/motivation-des-tages. html Always say what you think! piss off !! you http: //kruemelmonsterag. blogspot. com/2009/05/motivation-des-tages. html Always say what you think! piss off !! you can only die once

Hartung, T. , van Vliet, E. , Jaworska, J. , Bonilla, L. , Skinner, Hartung, T. , van Vliet, E. , Jaworska, J. , Bonilla, L. , Skinner, N. , & Thomas, R. (2012) Systems Toxicology. Altex-Alternatives to Animal Experimentation, 29, 2, pp 119 -128 http: //www. ask-force. org/web/Seralini/Hartung-Systems-Toxicology-Food-for-Thought-2012. pdf

Fig. 3. Flowering plants of Silene stenophylla. (A) Plant grown in vitro culture from Fig. 3. Flowering plants of Silene stenophylla. (A) Plant grown in vitro culture from seed of an extant plant. (B) Plant regenerated in vitro culture from tissue of fossil fruit with primary strictly female flower. (C) Plant regenerated from tissue of fossil fruit with both female (f) and bisexual (b) flowers. Silene stenophylla 31‘ 000 years old Yashina, S. , Gubin, S. , Maksimovich, S. , Yashina, A. , Gakhova, E. , & Gilichinsky, D. (2012) Regeneration of whole fertile plants from 30, 000 -y-old fruit tissue buried in Siberian permafrost. Proceedings of the National Academy of Sciences, 109, 10, pp 4008 -4013 http: //www. pnas. org/content/109/10/40 08. abstract AND http: //www. ask-force. org/web/Global. Warming/Yashina-Regeneration-30000 -year-Silene-stenophylla-2012. pdf