REGULATION OF ENZYME ACTIVITY Irreversible competitive inhibition Irreversible

REGULATION OF ENZYME ACTIVITY

Irreversible competitive inhibition

Irreversible competitive inhibition

Activation of the enzyme by phosphorylation

Regulation of activity by dissociation of the subunits of the enzyme Protein kinase

Partial proteolysis inactive enzyme active enzyme

Allosteric regulation of enzyme activity

Feedback inhibition

ENZYMES IN MEDICINE

Enzymes as therapeutic agents

Enzymes as analytical agents

(stain)

Indicator enzymes

Vitamins

James Lind N.I. Lunin

K. Funk N.D. Zelinsky

Classification of some vitamins (for therapeutic and prophylactic effect)

Fat soluble vitamins Vitamin A (retinol)

Vitamin D ergosterol D2 (ergocalciferol) 7-dehydrocholesterol D3 (cholecalciferol)

Richets

Rachitic bone deformation

Vitamin E (tocopherol)

Vitamin K1 (phylloquinone)

Vikasol Vitamin К3 (menadione)

Water soluble vitamins Vitamin C (L-ascorbic acid)

Ascorbic acid oxidation Oxalic acid

Scurvy

Vitamin B1 (thiamine) Thiamine pyrophosphate

Beri beri (polyneuritis)

Vitamin B2 (riboflavin)

Vitamin PP (niacin, vitamin B3) nicotinic acid nicotinamide

Vitamin B6 (pyridoxine) Pyridoxol Pyridoxamine Pyridoxal

Active form of B6 Pyridoxal phosphate

Vitamin B12 (cobalamin)

Folic acid (vitamin Bc)

Vitamin B5 (pantothenic acid) Residue of ,-deoxy- , -dimetilbutanoic acid -alanine residue

Coenzyme A Residue of pantothenic acid

Vitamin H (Biotin)

Vitamin P (Rutin)

Vitamin U (S-metilmetionin)

Choline

Inositol

Para-aminobenzoic acid

Antivitamin PP -acetilpyridine - pyridine sulfonic acid

Antivitamin K dikumarol warfarin