REGULATION OF ENZYME ACTIVITY Irreversible competitive inhibition Irreversible
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REGULATION OF ENZYME ACTIVITY
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Irreversible competitive inhibition
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Irreversible competitive inhibition
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Activation of the enzyme by phosphorylation
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Regulation of activity by dissociation of the subunits of the enzyme Protein kinase
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Partial proteolysis inactive enzyme active enzyme
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Allosteric regulation of enzyme activity
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Feedback inhibition
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ENZYMES IN MEDICINE
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Enzymes as therapeutic agents
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Enzymes as analytical agents
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(stain)
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Indicator enzymes
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Vitamins
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James Lind N.I. Lunin
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K. Funk N.D. Zelinsky
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Classification of some vitamins (for therapeutic and prophylactic effect)
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Fat soluble vitamins Vitamin A (retinol)
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Vitamin D ergosterol D2 (ergocalciferol) 7-dehydrocholesterol D3 (cholecalciferol)
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Richets
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Rachitic bone deformation
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Vitamin E (tocopherol)
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Vitamin K1 (phylloquinone)
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Vikasol Vitamin К3 (menadione)
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Water soluble vitamins Vitamin C (L-ascorbic acid)
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Ascorbic acid oxidation Oxalic acid
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Scurvy
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Vitamin B1 (thiamine) Thiamine pyrophosphate
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Beri beri (polyneuritis)
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Vitamin B2 (riboflavin)
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Vitamin PP (niacin, vitamin B3) nicotinic acid nicotinamide
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Vitamin B6 (pyridoxine) Pyridoxol Pyridoxamine Pyridoxal
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Active form of B6 Pyridoxal phosphate
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Vitamin B12 (cobalamin)
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Folic acid (vitamin Bc)
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Vitamin B5 (pantothenic acid) Residue of ,-deoxy- , -dimetilbutanoic acid -alanine residue
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Coenzyme A Residue of pantothenic acid
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Vitamin H (Biotin)
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Vitamin P (Rutin)
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Vitamin U (S-metilmetionin)
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Choline
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Inositol
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Para-aminobenzoic acid
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Antivitamin PP -acetilpyridine - pyridine sulfonic acid
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Antivitamin K dikumarol warfarin
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19602-lecture_3_enzymes,_vitamins.ppt
- Количество слайдов: 60