Proline and lysine residues 4 — hydroxyproline ,

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Proline and lysine residues 4 - hydroxyproline , 5 - hydroxylysine residues Proline and lysine residues 4 — hydroxyproline , 5 — hydroxylysine residues

Desmosine Desmosine

С- terminal enddisulphide bonds С- terminal enddisulphide bonds

binding site of collagen and proteoglycans binding site of laminin binding site of collagen and proteoglycans binding site of laminin

hyaluronic acid hyaluronic acid

1 — chains of chondroitin sulphate 2 — chains of keratan sulphate 3 — polypeptide chain1 — chains of chondroitin sulphate 2 — chains of keratan sulphate 3 — polypeptide chain HA — hyaluronic acid

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34 Adrenalin Noradrenalin Dopamin 34 Adrenalin Noradrenalin Dopamin

BIOCHEMISTRY OF MUSCLE TISSUE BIOCHEMISTRY OF MUSCLE TISSU

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Sarcoplasmic proteins (35) glycolytic enzymes of tissue respiration, oxidative phosphorylation, nitrogen and lipid metabolism myoglobin parvalbuminsSarcoplasmic proteins (35%) glycolytic enzymes of tissue respiration, oxidative phosphorylation, nitrogen and lipid metabolism myoglobin parvalbumins

Myofibrillar proteins (45) Myosin Actomyosin regulatory proteins (tropomyosin, troponin, α- and β-actinin). Myofibrillar proteins (45%) Myosin Actomyosin regulatory proteins (tropomyosin, troponin, α- and β-actinin). Stromal proteins (20%) Collagen Elastin

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41 Structure of myosin molecule 41 Structure of myosin molecule

42 Actine structure 42 Actine structure

43 Structure of thin filament 43 Structure of thin filament

Creatine kinase mechanism Creatine phosphate + ADP Creatine + ATP Miokinase mechanism : 2Creatine kinase mechanism Creatine phosphate + ADP Creatine + ATP Miokinase mechanism : 2 ADP = ATP + AMP Glycolytic mechanism (lactate, anaerobic) Aerobic ATP resynthesis mechanism (oxidative phosphorylation)

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