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Organs for research and education Matthew Bock Organs for research and education Matthew Bock

When are organs used for research? Only after they have been determined unsuitable for When are organs used for research? Only after they have been determined unsuitable for transplant

What makes an organ unsuitable for transplant? n n Performance Condition What makes an organ unsuitable for transplant? n n Performance Condition

Performance Kidneys Creatinine Liver AST/ALT Pancreas A 1 C Heart Troponin, Echo Lungs X-ray, Performance Kidneys Creatinine Liver AST/ALT Pancreas A 1 C Heart Troponin, Echo Lungs X-ray, PO 2

Condition n Fatty pancreas Polycystic kidney Fibrotic or fatty liver Condition n Fatty pancreas Polycystic kidney Fibrotic or fatty liver

If we can’t transplant… There is still an option… Research consent If we can’t transplant… There is still an option… Research consent

Page 2 (back) of consent form Page 2 (back) of consent form

Page 2 (back) of consent form Page 2 (back) of consent form

Research consent for transplanted organs n Liver study n n Lung study n n Research consent for transplanted organs n Liver study n n Lung study n n Biopsy Bronch washings and blood ample Kidney study

Order n n n 1 st - Transplant 2 nd- In-house research 3 rd Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National

Order n n n 1 st - Transplant 2 nd- In-house research 3 rd Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National

Order n n 1 st - Transplant 2 nd- In-house research n n Pancreas Order n n 1 st - Transplant 2 nd- In-house research n n Pancreas islet cells 3 rd - National

Order n n n 1 st - Transplant 2 nd- In-house research 3 rd Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National

Order n n n 1 st - Transplant 2 nd- In-house research 3 rd Order n n n 1 st - Transplant 2 nd- In-house research 3 rd - National n n NDRI IIAM

Who are NDRI and IIAM? n NDRI, National disease research interchange IIAM, International Institute Who are NDRI and IIAM? n NDRI, National disease research interchange IIAM, International Institute for the Advancement of Medicine n Both are 501 c non-profit n

Heart, Arteries and Veins Medical investigators use the human heart to learn about the Heart, Arteries and Veins Medical investigators use the human heart to learn about the development of atherosclerosis in coronary arteries

Kidneys Renal tissues is used to study the toxicity of anti-cancer therapies and to Kidneys Renal tissues is used to study the toxicity of anti-cancer therapies and to study the safe concentrations of other drugs in development

Lungs Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, emphysema and allergies Lungs Research into chronic obstructive pulmonary disease (COPD), cystic fibrosis, asthma, emphysema and allergies

Pancres Diabetes researchers rely on pancreatic tissues to explore the regulation of insulin production, Pancres Diabetes researchers rely on pancreatic tissues to explore the regulation of insulin production, to identify the genetic components of the disease and for toxicity studies on new compounds.

Liver n n Hepatocyte cell isolation for transplantation Human model for drug interaction, toxicity Liver n n Hepatocyte cell isolation for transplantation Human model for drug interaction, toxicity and metabolism testing

Education n Whole body donation Education n Whole body donation