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Mechanistic Insights Into Very Slow Conduction in Branching Cardiac Tissue by Jan P. Kucera, Mechanistic Insights Into Very Slow Conduction in Branching Cardiac Tissue by Jan P. Kucera, and Yoram Rudy Circulation Research Volume 89(9): 799 -806 October 26, 2001 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. Characteristics of propagation across a single branching site under normal [K+]o, for Figure 1. Characteristics of propagation across a single branching site under normal [K+]o, for branch lengths (L) of 2 cells (118 μm, A) and 10 cells (588 μm, B). Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. Peak push current in single branching networks as a function of branch Figure 2. Peak push current in single branching networks as a function of branch length. Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 3. Effects of blocking the push current on propagation across a single branch Figure 3. Effects of blocking the push current on propagation across a single branch point for L=2 cells in normal [K+]o. Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 4. Propagation delay induced by single branching as a function of branch length, Figure 4. Propagation delay induced by single branching as a function of branch length, L, for control (A) and premature APs (B). Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 5. A, θ in multiple branching networks as a function of branch length, Figure 5. A, θ in multiple branching networks as a function of branch length, for different distances between branching sites (indicated by numbers in traces). Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 6. Effects of blocking the push current at all branch points on θ Figure 6. Effects of blocking the push current at all branch points on θ in multiple branching structures. θ in the absence of the push current was normalized to θ in its presence. Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 7. Effects of blocking the push current at one given branch point on Figure 7. Effects of blocking the push current at one given branch point on propagation across a network with multiple branches (L=4 cells, D=4 cells), in elevated [K+]o. Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.

Figure 8. Safety factor for propagation (SF) as a function of θ, under conditions Figure 8. Safety factor for propagation (SF) as a function of θ, under conditions of normal (A) and elevated [K+]o (B). Jan P. Kucera, and Yoram Rudy Circ Res. 2001; 89: 799 -806 Copyright © American Heart Association, Inc. All rights reserved.