i jm THE INFLUENCE OF ASCORBIC ACID ON

i jm THE INFLUENCE OF ASCORBIC ACID ON NONSPECIFIC RESISTANCE OF THE BODY Performed: Gagarinova А.К, 2nd year student group № 204 Scientific advisors: Litvinenko L. А. Кuzinа V. А.

Ascorbic acid Synonyms : Vitamin C, Ascorbin, Ascorbit, Askorvit, Cantan etc.; water-soluble; white crystalline powder with sour taste; quickly destroyed by high temperature and during prolonged storage of food; Ascorbic acid is lactone acid, similar in structure to glucose. Vitamin C is:

Chemical formula: C6H8O6 Chemical structure spatial structure L-ascorbic acid (lactone 2,3-dehydro-L-gulonic acid)

Forms of vitamin C: L-ascorbic acid Dehydroascorbic acid 2e Free radical L-ascorbic acid L-ascorbate-anion H+ H+ H+ H+ H+ H+ H+ H+ e e e e e e 2e

A lot of animals can synthesize ascorbic acid from glucose. Еxception:

glucose D-glucuronic acid L-gulonic acid L-gulonolakton L-gulonolaktonoxidase 2-ketogulonolakton L-Ascorbic acid glucuronatreductase aldonolactonase

The immune system Vitamin C promotes to increase production : the production of leukocytes

the production of antibodies

the production of interferon

НАDH Antioxidative properties Dehydroascorbic acid Ascorbic acid Vitamin E Vitamin E radical (F) Antiradical chain GSH GSSG

Аscorbate + nonenzymic dismutation Active forms of oxygen

Synthesis of pro-a-chains ribosome granular ER hydroxylation of certain proline and lysine residues glycosylation of certain residues gidroksilizina processes in intracellular membrane structures (ER, Golgi apparatus, secretory vesicles) formation of triple helix plasma membrane secretion procollagen molecule Detachment of terminal peptides microfibril assembly collagen molecule microfibrille assembly of mature collagen fibrils Collagen fibril aggregation of fibrils in collagen fibers collagen fibers Hydroxylation of proline and lysine residue Pro prolyl hydroxylase ascorbic acid residue Hyr pro-a-chains a-KG L-ascorbic acid Dehydroascorbic acid Collagen - the main structural protein of the extracellular matrix.

Acute viral respiratory diseases (AVRD)

Linus Pauling and vitamin C 28 February1901 – 19 August 1994 1970

Daily rate of vitamin C

Efficiency of ascorbic acid for prophylaxis of AVRD among the children in health-improving kindergarten in Saint-Petersburg The percentage of incidence rate has been decreased in 1,5 times

Vitamin C in food foods of plant origin (mg/100g) 2400 450 300 40 30

food of animal origin (mg/100g) 0,9 2,0

Vitamin C under the microscope (an increase of 10x and above) Thank you for your listening Thank you for your time