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History of Varian HPLC Frankie Button HPLC Instrument Manager, Europe Region 1 November 2007 History of Varian HPLC Frankie Button HPLC Instrument Manager, Europe Region 1 November 2007

1966 is where it all started……. . 1966 – LC Research and Development Group 1966 is where it all started……. . 1966 – LC Research and Development Group of Varian was formed LC Development and Innovation took place every 1 to 3 years. In the early years this was mainly by product development In later years this has been mainly by acquisition

History of Varian HPLC Products 1967 – Model 4000 Gas Displacement Pump and Microadsorption History of Varian HPLC Products 1967 – Model 4000 Gas Displacement Pump and Microadsorption detector (MAD)

History of Varian HPLC Products 1968 – Varian purchased LC Division of Picker-Nuclear (Dedicated History of Varian HPLC Products 1968 – Varian purchased LC Division of Picker-Nuclear (Dedicated Nucleotide Analyzer, LCS-1000, 254 nm UV detector. 1971 – Model 4200 Gradient Elution Chromatograph (syringe pump), Variscan Scanning UV Detector (Techtron – Melbourne)

History of Varian HPLC Products 1974 - Model 8500 HPLC syringe pump, RI detector, History of Varian HPLC Products 1974 - Model 8500 HPLC syringe pump, RI detector, 8000 Auto. Sampler for HPLC, CDS 101

History of Varian HPLC Products 1976 – Varichrom Variable Wavelength UV-Vis detector (Cary) 2 History of Varian HPLC Products 1976 – Varichrom Variable Wavelength UV-Vis detector (Cary) 2 nd Generation CDS System, with system control!

History of Varian HPLC Products 1977 – Fluorichrom filter fluorimeter History of Varian HPLC Products 1977 – Fluorichrom filter fluorimeter

History of Varian HPLC Products 5000 series HPLC pump, major step forward • 5010 History of Varian HPLC Products 5000 series HPLC pump, major step forward • 5010 Isocratic analog pump • 5020 Binary gradient computer controller • 5030 Isocratic computer controller UV-1 254 detector

History of Varian HPLC Products Inside the 5020 History of Varian HPLC Products Inside the 5020

History of Varian HPLC Products 1979 – UV-50 UV-Vis detector 1980 – vista 54/56 History of Varian HPLC Products 1979 – UV-50 UV-Vis detector 1980 – vista 54/56 HPLC (Controlled by Vista 401 chromatography data station) 5060 Ternary gradient HPLC pump

History of Varian HPLC Products 1981 – Post Column Reactor, RI-3 (refractive index detector History of Varian HPLC Products 1981 – Post Column Reactor, RI-3 (refractive index detector from LDC) 1982 – UV-100 time programmable UV-Vis detector with fast HPLC option! 1983 – 5560 HPLC, scanning UV-200 detector, 8085 integrated Auto. Sampler, CDS-402 for control

History of Varian HPLC Products 1984 – 9090 low loss variable volume Auto. Sampler, History of Varian HPLC Products 1984 – 9090 low loss variable volume Auto. Sampler, 2010 Isocratic pump, 2020 Gradient controller, 2050 Programmable UV-Vis detector, 2070 Monochrometer based Fluorescence detector (all from Jasco)

History of Varian HPLC Products 1985 – Poly. Chrom 9060 Diode Array Detector, AASP History of Varian HPLC Products 1985 – Poly. Chrom 9060 Diode Array Detector, AASP Automated solid phase extraction system ( Online SPE!!!)

History of Varian HPLC Products 1986 – CM-1 conductivity detector (OEM), DS-604 GPC calculation History of Varian HPLC Products 1986 – CM-1 conductivity detector (OEM), DS-604 GPC calculation software 1987 – RI-4 (OEM from ERC in Japan), 2500 Isocratic pump, 2502 Isocratic pump and gradient controller, 2550 time programmable UV-Vis detector (Jasco)

History of Varian HPLC Products 1988 – Star 9010 ternary gradient pump, 9050 time History of Varian HPLC Products 1988 – Star 9010 ternary gradient pump, 9050 time programmable UVVis detector, 9095 High Performance Auto. Sampler, 9065 Diode Array detector, 9020 Windows based HPLC workstation

History of Varian HPLC Products 1989 – LC Workstation Rev C, SP-99 column oven History of Varian HPLC Products 1989 – LC Workstation Rev C, SP-99 column oven (Spark Holland) 1990 – 3 D View for Poly. View, PCR carbamate system (Pickering), 9001 Isocratic pump, Marathon Auto. Sampler (Spark Holland) 1991 – 9070 Fluorescence Detector (Linear, Spectra Physics, Thermo), 9100 Cooled Auto. Sampler 1992 – MCA for Poly. View 1993 – 9012/9002 extended flow range pumps, Mistral oven (Spark Holland), Electric 9100

History of Varian HPLC Products 1994 – Workstation version 4. 0 (LC and GC History of Varian HPLC Products 1994 – Workstation version 4. 0 (LC and GC combined), Poly. View 4. 0 (Iso. View), 9300 Auto. Sampler (Spark Holland), Prospekt Automated solid phase extraction (Spark Holland)

History of Varian HPLC Products 1995 – Star 9080 Electrochemical detector ( Antec), Star History of Varian HPLC Products 1995 – Star 9080 Electrochemical detector ( Antec), Star 9040 RI detector (ERC), Star control of 9200 and 9300 1996 – 9025 Automation panel, LC/NMR, 9012 Quaternary pump, 9075 fluorescence detector (Thermo) 1997 – Varian buys Rainin – SD-200/300, SD-1, UV-C, UV-D, PDA-2, AI-1 A, AI-96, AI-03, Ram. Pak, ISCO FC-1, ISCO, FC-4

History of Varian HPLC Products 1998 – Pro. Star product line ( combines Rainin History of Varian HPLC Products 1998 – Pro. Star product line ( combines Rainin and Varian products), Pro. Star 330 Photodiode Array (Hitachi) Poly. View 2000 1999 – Pro. Star 500 CVM, Helix system 2000 – Pro. Star 363 Fluorescence detector, Varian buys Van Kel, Varian buys R&S, 520 Oven

History of Varian HPLC Products 2001 – Prep. Star SD-2, Prep. Star 530, Responder History of Varian HPLC Products 2001 – Prep. Star SD-2, Prep. Star 530, Responder software, Helix 364 Fluorescence software, Star Reviewer for d. HPLC, Polaris Educational systems 2003 – Pro. Star 325 UV/Vis detector

Key technical advances for Varian HPLC Variscan - scanning UV-Vis detector 1971 5000 pump Key technical advances for Varian HPLC Variscan - scanning UV-Vis detector 1971 5000 pump – single piston single pump ternary gradient system 1978 Vista 401 – 4 channel, control LC and GC, dual high speed printers, replot with baseline, raw data storage 1980 UV 100 – No RI high performance analytical product 1982 Poly. Chrom 9060 PDA with mathematical evaluation of purity – 1985 Star Workstation – Windows based data system, 1988 Poly. View spectral processing software – 1988 (MCA 1992) SD-1 – the Waters alliance before there was an alliance – 1991 with Rainin. (A fire truck without the wheels) Pro. Star 500 CVM – The ultimate in valving capability – 1999

Varian products that lasted 5000 pump deign – now in Pro. Star 230 Vista Varian products that lasted 5000 pump deign – now in Pro. Star 230 Vista 401 capabilities – now in Star and Galaxie UV-100 design – Obsolete in 2003 by Pro. Star 325 Spectral processing software – never surpassed!

Products that customers loved LC 5000 – many are still working today Star 9010/9012/230 Products that customers loved LC 5000 – many are still working today Star 9010/9012/230 – same as above Vista 401 – Incredible innovation and very easy to use UV-100/9050/Pro. Star 310 – they were the workhorses of the lab SD-1 – Unparalleled Performance SD-200/SD-300/218 – the best in world for analytical to small scale prep

HPLC at Varian for over 40 Years Varian have always been, and always will HPLC at Varian for over 40 Years Varian have always been, and always will be an Innovator in HPLC Even in the last 10 years we have produced product after product, and several acquisitions Over $8 M Invested in the last 4 years to put us back on the HPLC Map This new Era starts with, because it’s the first of many NEW HPLC products:

The Future………. . i. HPLC The Future………. . i. HPLC

Concept of the i. HPLC • 1 st Fully Integrated HPLC System • Easy Concept of the i. HPLC • 1 st Fully Integrated HPLC System • Easy to use, install and MAINTAIN • Compact and Stylish in Design • Complementary to part of existing modular line • A Major step forward in performance and ergonomics and User Experience • Single part numbers, easier to sell 26

i. HPLC q. Two New Models §Analytical to Prep i. HPLC q. Two New Models §Analytical to Prep

i. HPLC Analytical Concept: • One Power Button • One Power Cable • One i. HPLC Analytical Concept: • One Power Button • One Power Cable • One Communication cable • …Whilst retaining the Self maintenance features • Pre-plumbed and “Ready” out of the box 28 • Sample tray accessible without opening doors

i. HPLC Analytical USP: • High Performance Analytical System • Can be Optimised easily i. HPLC Analytical USP: • High Performance Analytical System • Can be Optimised easily for good Fast LC performance • The “First COMPLETE Integrated Solution” • Simplicity in a one Box • Simple to Install…Simple to Use. . Simple to Maintain 29 • Neat, Compact and Stylish product

i. HPLC Analytical Consists of: • NEW Pumps • NEW Autosampler • NEW Detectors i. HPLC Analytical Consists of: • NEW Pumps • NEW Autosampler • NEW Detectors • Existing UV/DAD Detectors in an Integrated format 30

i. HPLC Analytical USP: • The Only complete range of High Performance Information Rich i. HPLC Analytical USP: • The Only complete range of High Performance Information Rich LC Detectors • IMS Software for simple user diagnostics, OQ and Service • Storage space for LC Columns, Fittings and Tubing • Tray Space for Columns, manual, tools, Software CD etc… 31

i. HPLC Analytical to Prep Consists of: • Existing 210/218 Pumps in several integrated i. HPLC Analytical to Prep Consists of: • Existing 210/218 Pumps in several integrated configurations • NEW Fraction Collector • NEW Prep Autosampler • NEW Module for Column and Solvent Selection • Existing UV/DAD Detectors in an Integrated format 32

i. HPLC Analytical to Prep Concept: • One Power Button/Cable • One Communication cable i. HPLC Analytical to Prep Concept: • One Power Button/Cable • One Communication cable • Easy interchangeability of components to retain flexibility • Pre-plumbed and “Ready” out of the box 33

i. HPLC Analytical to Prep USP: • High Performance Analytical System • High Performance i. HPLC Analytical to Prep USP: • High Performance Analytical System • High Performance “Analytical to Prep” System • High Performance Prep System • The “Only COMPLETE Integrated Solution” • Accepted Hardware 34

i. HPLC Analytical to Prep USP: • Simple to Install…Simple to Use. . Simple i. HPLC Analytical to Prep USP: • Simple to Install…Simple to Use. . Simple to Maintain • Neat, Compact and Stylish product • Modern, Stylish Fraction Collector…That works! • Simple FC programming and manual intervention • New Switching module concept, stylish design 35

Galaxie Driver • Awesome interface • Very “Easy on the eye” –shockwave technology • Galaxie Driver • Awesome interface • Very “Easy on the eye” –shockwave technology • Simple to use • An enormous step forward • Installation configurator – simple to install 36

Other Highlights • Solvent tray capacity • “Ski Slopes” for sample tray insertion/removal • Other Highlights • Solvent tray capacity • “Ski Slopes” for sample tray insertion/removal • Single waste port • Easy access for servicing/tubing and fitting replacement • Leak detector 37

Other Highlights • Modern Manual Injectors – push button • Bottle Management • Software Other Highlights • Modern Manual Injectors – push button • Bottle Management • Software Tool Tips – makes everything easy • Online Help and Videos “ Cary Style” • Excellent Brochures – hoorah a brochure!!!!!!! • New Data Sheets/Price Lists and App Notes 38

Positioning • Form part of our New LC range • Still have modular options Positioning • Form part of our New LC range • Still have modular options – very important • Rebranded XXX-LC, eliminate Pro. Star name • First product 356 -LC Refractive Index plus – 210/218/325/335 etc. . • New Grey “ Barbie Showers” 39

Positioning • Integrated Systems(i. HPLC) – Standard popular configurations – New Format Analytical Semi-Prep Positioning • Integrated Systems(i. HPLC) – Standard popular configurations – New Format Analytical Semi-Prep • Modular Systems(XXX-LC) – Low cost systems Process EXCELLENT AND – Odd configurations COMPREHENSIVE RANGE GPC – Biocompatible OF CONSUMABLES – Online SPE Flash • Prep 2 Process/Flash LC • GPC Systems 40 Turnkey Custom

Conclusion • Compact and Stylish Integrated Systems • Retain flexibility and maintenance features • Conclusion • Compact and Stylish Integrated Systems • Retain flexibility and maintenance features • Excellent hardware performance • Excellent User Interface – pleasant experience • Simple to Install • Fits the topical “Fast LC” Model using our Two Brand NEW Small Particle LC Columns 41