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ESHRE 26 th Annual Meeting, Rome. Wednesday 30 June 2010 ESHRE Members’ information session ESHRE 26 th Annual Meeting, Rome. Wednesday 30 June 2010 ESHRE Members’ information session New task force - Fertility and viral disease Enrico Semprini (Italy)

New: Task Force – Fertility and Viral Diseases Coordinator: Augusto E. Semprini § Aim: New: Task Force – Fertility and Viral Diseases Coordinator: Augusto E. Semprini § Aim: This Task Force aims to offer a platform of collaboration between ESHRE and the "Centres for Reproductive Assistance Techniques in HIV in Europe" (CREATHE), which is a non-profit association committed to improving the quality and availability of safer conception options to couples who are affected by HIV and/or other transmissible infections and who wish to become parents. • These couples are nowadays subject to discrimination regarding their basic rights for parenthood and for having a family, due to the fear of transmitting the infection to the healthy partner while attempting at conception. • CREATh. E O. N. L. U. S. is an NGO registered under Italian law. (www. creathe. org) • CREATh. E is an open network welcoming the inclusion of all figures involved in the field of reproductive care to couples with HIV. To

Task Force – Fertility and Viral Diseases The key objectives of CREATHE are: • Task Force – Fertility and Viral Diseases The key objectives of CREATHE are: • To promote the availability of services of assisted reproduction to couples affected by HIV or by other sexually transmitted infections. • To promote the offer of services of specific sperm washing to clinical centres unequipped in carrying out this method who intend to offer reproductive assistance to couples affected by HIV or by other sexually transmitted infections. • To spread knowledge and experience regarding the method of sperm washing and regarding reproductive assistance to couples affected by HIV or by other sexually transmitted infections, to physicians and biologists who intend applying this method.

Reproductive Centres BELGIUM Saint-Pierre hospital, Bruxelles Erasme hospital, Bruxelles DENMARK Rigshospitale, Copenhagen FRANCE Hospital Reproductive Centres BELGIUM Saint-Pierre hospital, Bruxelles Erasme hospital, Bruxelles DENMARK Rigshospitale, Copenhagen FRANCE Hospital Paule de Viguier, Toulouse CMCO-SIHCUS, Schiltigheim CHU de Lyon Hòpital Cochin, Paris Hòpital Pitié-Salpètrière, Paris CHU de Rennes GERMANY Fertility Center, Berlin ISRAEL Rambam hospital, Haifa ITALY Studio Semprini, Milano Centro di medicina preventiva, Verona NETHERLANDS Academisch Medisch Centrum, Amsterdam SPAIN Hospital Galdakao-Usansolo HU Virgen de las Nieves, Granada SOUTH AFRICA University hospital, Pretoria SWITZERLAND Kantonsspital St. Gallen, St. Gallen Clinique La Source, Lausanne U. K. Chelsea&Westminster hospital, London

Where do we come from? • Insemination of HIV-negative women with processed semen of Where do we come from? • Insemination of HIV-negative women with processed semen of HIV-positive partners. (AE Semprini -Lancet. 1992) • NATURAL CONCEPTION IN HIV-NEGATIVE WOMEN WITH HIV-INFECTED PARTNERS (L Mandelbrot Lancet 1997) • QUANTIFICATION OF HIV IN SEMEN: CORRELATION WITH ANTIVIRAL TREATMENT AND IMMUNE STATUS (PL Vernazza- AIDS 1997) • REPRODUCTIVE COUNSELLING FOR HIV-DISCORDANT COUPLES (AE Semprini- Lancet 1997)

HIV in semen: sperm washing Percoll Gradient HIV Infection 45% NSCs yes Motil spermatozoa HIV in semen: sperm washing Percoll Gradient HIV Infection 45% NSCs yes Motil spermatozoa No 90%

Semen preparation: sperm washing Gradient „swim-up“ 45% 90% Insem. Semen preparation: sperm washing Gradient „swim-up“ 45% 90% Insem.

Publications • Safety and efficacy of sperm washing in HIV-1 -serodiscordant couples where the Publications • Safety and efficacy of sperm washing in HIV-1 -serodiscordant couples where the male is infected: results from the European CREATh. E network. Bujan L, Hollander L et al. for the CREATh. E network. AIDS 21: 1909– 1914, 2007 Establishing the safety profile of sperm washing followed by ART for the treatment of HIV discordant couples wishing to conceive. A E Semprini , L Bujan et al. Hum Reprod. 2007 Jul 3 HIV-discordant couples and parenthood: how are we dealing with the risk of transmission? Vernazza PL; Hollander L et al. AIDS 20(4): 635, 2006 Multicenter Quality Control of the Detection of HIV-1 Genome in Semen Before Medically Assisted Procreation. Pasquier C, Anderson D et al. and The CREATh. E Network. J Med Virol 78: 877 -882, 2006 •

Projects • Retrsospective evaluation of the safety and efficacy of semen washing in HIV Projects • Retrsospective evaluation of the safety and efficacy of semen washing in HIV discordant couples • Retropsective evaluation of the outcome of infertility treatment in HIV positive women • SHARE – Studying HIV And Reproduction in Europe – European registry of reproductive assistance to couples with HIV • Multicenter Quality Control of the Detection of HIV-1 Genome in Semen Before Medically Assisted Procreation

Previous Collaboration with CDC • CONRAD's Mission • CONRAD's overall goal is to improve Previous Collaboration with CDC • CONRAD's Mission • CONRAD's overall goal is to improve reproductive health, especially in developing countries. Our main objective is to help develop safe, acceptable, affordable products and methods that provide contraception and/or prevent the sexual transmission of HIV/AIDS and other infections • Manuscript submitted for publication

Task Force – Fertility and Viral Diseases ESHRE- CREATh. E Ongoing projects • Web Task Force – Fertility and Viral Diseases ESHRE- CREATh. E Ongoing projects • Web survey on the “Management of HIV-patients requesting reproductive assistance” • SHARE protocol and database • Pre Congress Course in Stockolm 2011 “Assisted Reproduction in couple with HIV” • Campus for healthcare professionals “ Viral Infections in Reproductive medicine “ Berlin 2012 • Position Papers