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CEBE IAB-Meeting Tallinn, September 16, 2013 CEBE IAB-meeting CEBE – Centre of Excellence for CEBE IAB-Meeting Tallinn, September 16, 2013 CEBE IAB-meeting CEBE – Centre of Excellence for “Integrated Electronic Systems and Biomedical Engineering“ Raimund Ubar Tallinn University of Technology Department of Computer Engineering

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus International Advisory Board WELCOME to Tallinn © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus International Advisory Board WELCOME to Tallinn ü Marta Rencz - Budapest University of Technology, Hungary ü Bashir M. Al-Hashimi - University of Southampton, UK ü Jürgen Bommer - Dialysezentrum Heidelberg, Germany ü Bernard Courtois - CMP, France ü Rainer Dorsch - Bosch, Germany ü Manfred Glesner - TU Darmstadt, Germany ü Ahmed Jerraya - CEA-LETI, MINATEC, France ü Jaakko Malmivuo - Tampere University of Technology, Finland ü Uwe Pliquett - Institut für Bioprozess- und Analytische Messtechnik, Germany 2

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Program Welcome 09: 00 R. Ubar © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Program Welcome 09: 00 R. Ubar General Overview about CEBE 09: 30 J. Raik Research on Verification and Diagnosis FP 7 DIAMOND 09: 55 A. Jutman Research on Testing. FP 7 BASTION Presentations 10: 20 -10: 50 Coffee 10: 50 M. Min Research on Signal Processing Cooperation with ELIKO 11: 20 I. Fridolin Research on Biomedical Engineering Cooperation with hospitals 11: 50 Presentations DISCUSSIONS 12: 30 -14: 00 Lunch 14: 00 -15: 30 Open lecture of Dr. Honoris Causa of TUT R. Kurki-Suonio 16: 00 – 17: 30 Discussions between IAB and CEBE management

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Overview ü General about CEBE (position © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Overview ü General about CEBE (position in Estonia, structure, research fields, new project activities, mission) ü Slogan of CEBE – HEALTH 2 ü Two types of synergy ü Overview about cooperation in CEBE ü Formal results (Ph. D defences, patents, publications, projects, external cooperation) 4

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus How CEBE Was Born National program © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus How CEBE Was Born National program (EU Structural Funds): „Development of Centres of Excellence in Research“ Period: 2008 -2015 Number of candidates – 24 Each consortium consisted of research groups who had a target financed project (financed from Ministry of Education) 7 + 5 centres (in 2011) were selected CEBE is one of the 12 Centres 5

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Estonian 12 Excellence Centres 2008 2011 © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Estonian 12 Excellence Centres 2008 2011 Tartu ü Genomics ü Mesosystems ü Chemical Biology ü ü Bio-diversity Research Dark Matter in Particle Physics and Cosmology ü Translational Medicine ü Environmental Adaptation ü Theory of Culture ü High-Technology Materials for Sustainable Development Tallinn ü ü Computer Science CEBE Tallinn ü Nonlinear Studies 6

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Mission of CEBE Mission: Improvement of © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Mission of CEBE Mission: Improvement of the quality of life through research and technological innovation n Electronics and signal processing Thomas Johan Seebeck Dept. of Electronics, TUT n System design, test, and diagnostics of Computer Engineering, TUT n Engineering in biology and medicine Technomedicum, TUT Dept. Application directions: n Mission-critical and dependable embedded systems n Advancing medical-, food- and biotechnology n Methods, algorithms & tools in signal processing, signal interpretation, design of embedded systems, test and verification 7

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Structure of CEBE Tallinn University of © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Structure of CEBE Tallinn University of Technology TJS DE ARCHIMEDES DCE TM CEBE Steering Committee CEBE Cooperation Projects IAB 8

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus People and Budget Number of part-time © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus People and Budget Number of part-time researchers: 45 (22 full positions with average salary of 1400 Eur per month) Number of doctorands: 64 Budget (thousands euros per year): Financial sources 2010 2011 -2013 (average) CEBE budget 583 29, 6% 555 30, 7% Estonian sources 600 30, 5% 513 28, 3% European projects 784 39, 9% 743 41, 0% Total 1. 967 100% 1. 812 100% 9

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus CEBE Competences Impedance spectroscopy Investigation of © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus CEBE Competences Impedance spectroscopy Investigation of brain signals Cardiac monitors, stimulators (EEG) Interpretation of Biosignals Optical analysis for dialysis Quality of blood vessels Signal processing algorithms Semiconductor technology 10

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Health Risk Prevention by Technology Sensors, © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Health Risk Prevention by Technology Sensors, equipments Risk factors Biosignals Health diagnosis tool Risks Doctors Healthcare plan 11

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Generic Distributed ES Architectures Ambient Assisting © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Generic Distributed ES Architectures Ambient Assisting Technologies Internet Gateway e. Health Middleware Local Data Concentrator 12

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Slogan of CEBE - Health 2 © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Slogan of CEBE - Health 2 Nested Health 2 Management Concept Biomedical engineering Test, Verification Diagnosis Design, Development Repair Medical knowledge Medical equipments, ICT PATIENT System Health DOCTOR Patient’s Health 13

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus CEBE Research Towards Health 2 System © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus CEBE Research Towards Health 2 System design Research in biomedical engineering Bioimpedance spectrography & tomography Brain research, EEG spectral analysis Optical dialysis monitoring Optical pulse wave measurement in arteries Applications Medical equipment Pacemakers Bioimpedance analysers Signal processing algorithms Design of dedicated processors Design for low power, speed, cost, reliability Mobile EEG analyser Equipments for optical signal measurement Information for doctors Design for dependability Verification, design error automated diagnosis and repair Automated testing and fault diagnosis

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Looking for Synergy > Internal Projects © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Looking for Synergy > Internal Projects CEBE research topics P 6 Verification, test and diagnosis (R. Ubar, J. Raik, A. Jutman) Design of Embedded Systems (P. Ellervee, G. Jervan, Th. Hollstein) P 2 P 1 Signal processing and bio-impedance spectroscopy (M. Min) P 7 Semiconductor technology (T. Rang) P 3 Optical Methods in Cardiology (K. Meigas) P 5 Optical Methods in Dialysis (I. Fridolin) Interpretation of Brain EEG Signals (H. Hinrikus) P 8 Platform for Embedded System Design P 4

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Synergy Computer Engineering Electronics External © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Synergy Computer Engineering Electronics External impact: Internal impact: Applications Improved Research Excellence EXPECTATIONs: (Two goals of CEBE) Technomedicum Research excellence Applications 16

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 1. Application © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 1. Application Specific Processors for Signal Processing in Biomedicine (E/CE – M. Min) Results: Methods of signal generation and processing for broad-band impedance spectroscopy with implementations in medicine and engineering New specific signal processor architectures (P. Ellervee) Products: Pacemakers (Cooperation with St. Jude Medical, USA) Impedance-spectroscopy measurement equipment QUADRA (Cooperation with Enterprise Estonia, start-up company Prototuba OÜ) Inventor prof. Mart Min was nominated among 3 selected candidates for the European Inventor Award 2011 17

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 2. Verification, © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 2. Verification, debug, DFT of Systems (CE: D/V – R. Ubar/J. Raik) Results: Methods for verification and automated debug of systems (J. Raik, M. Jenihhin) Prototype: Fast fault simulator (speed-up 5 -10 times, compared to commercial analogs) (S. Devadze) 180. 0 New testability marker, 160. 0 easily to be calculated 140. 0 Tetra. MAX 120. 0 from the circuit structure Gate-level 100. 0 Macro-1 Characterizes the circuit 80. 0 Macro-2 60. 0 complexity Mem, MB 40. 0 20. 0 1 2 3 4 5 6 7 8 18

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 2. Verification, © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 2. Verification, debug, DFT (CE: D/V – R. Ubar/J. Raik) Result: New family of benchmark circuits ordered by the complexity (by the values of the testability marker) 700% Cost of processing (time) 600% Test generation Fault simulation Test length 500% 400% 300% 200% 100% 0% 8 a Sharing of resources Increase of complexity 8 b 8 bk 8 c 8 d 8 be 8 de 8 bs Complexity 19

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 2. Verification, © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 2. Verification, debug, DFT (CE: D/V – R. Ubar/J. Raik) Result: Novel at-speed on-line functional test method for signal processors (by using inherent specific signals instead of Fault coverage LFSRs or ATPG tests) (M. Gorev) LFSR Chirp Sine Sawtooth Signal processor 20 Test length

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus HLDD Verification and Design Repair ü © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus HLDD Verification and Design Repair ü P 2. Verification, debug, DFT of systems Novelty: A new possibility formal verification of digital systems, Implementation Specification design error detection and automated repair Specification Each graph is represented by unique polynomials as a canonical model of the system Decision Diagrams Bug

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Managing the Complexity with HLDDs Program © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Managing the Complexity with HLDDs Program data flow State space A=FA 1 (. . . ) High-Level Decision Diagrams D Behavior of A E C B B=FB 1 (. . . ) C=FC 1 (. . . ) A=FA 2 (B, C, . . . ) A=FAn (D, E, . . . ) Novelty: Instead of reasoning the design as a whole, it will be partitioned into the behavioral sub-models of functional variables (HLDDs) 22

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 3. Total © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 3. Total Peripheral Resistance (E/TM – K. Meigas) Results: Methods for continuous and noninvasive optical monitoring of blood pressure and diagnosis of atherosclerosis Distinguishing high sudden death risk patients in various heart diseases Product: Software for commercial Holter monitor devices By spin-off company Tensiotrace OÜ, Estonia Clinical experiments in the hospital PERH, Estonia 23

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 4. Evaluation © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 4. Evaluation of mental disorders using EEG analyser (CE/TM – M. Jenihhin/H. Hinrikus) Results: EEG spectral asymmetry index was invented (SASI algorithm), which allowed to develop a new method for determining depressive disorders by measuring EEG signals of the brain (H. Hinrikus) Prototype: Portable EEG analyzer for detecting mental disorders (M. Jenihhin) Clinical experiments are going on 24

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 5. Reliable © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 5. Reliable and disturbance free monitoring of dialysis (CE/TM – I. Fridolin) Results: Methods for multicomponent monitoring of uremic toxins in biofluids during dialysis Product: Medical equipment for dialysis dose monitoring Diasens By Enterprise Estonia, AS Ldiamon 25

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 6. Testing © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 6. Testing of electronic systems (E/CE – A. Jutman) ü Results: Methods and a system for automated test program synthesis for electronic boards ü Methods and high-performance embedded instrumentation in electronic boards ü Products: • Microprocessor models for testing • Embedded instrumentation IPs for testing of PCBs and IC chips (Göpel Electronics Gmb. H, Germany) • BERT (Bit-Error-Rate) Test Equipment (CERN, Switzerland) By spin-off Testonica Lab, Estonia 26

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 7. Semiconductor © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 7. Semiconductor Technology (T. Rang) ü Results: Two new approaches have been developed to increase the yield in manufacturing of high speed Ga. As power diodes ü Cooperation partners: • Ioffe Physical-Technical Inst. of Russian Acad. of Sciences, • Power Electronics Dept. (TUT) Products: High speed power Ga. As structures using the LPE technology By By Clifton Ltd, Estonia 27

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 7. Semiconductor © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Projects ü P 7. Semiconductor Technology (T. Rang, R. Ubar) Goals: Defect-oriented Testing with advanced fault models Multiple fault 0 1 Resistive bridge fault Defect SAF Conditional fault Pattern fault Constrained SAF Single faulty signal X-fault Byzantine fault Bridges Stuck-opens Multiple faulty signal 28

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Dependable ES Design Platform Novel methods © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Dependable ES Design Platform Novel methods in design for dependability: Platform based design environment for dependable embedded systems n Fault simulation n Automated synthesis and analysis of test programs n System verification and design error diagnosis n Automated design error repair n Dependability of No. C-based System-on-Chips Algorithms, solutions Architectures, components Signal source, sensors Design space exploration Prototype 29

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus D&T Environment for Research Possibility for © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus D&T Environment for Research Possibility for wide range of experimental scenarios 30

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus CEBE International Cooperation ü Europrojects during © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus CEBE International Cooperation ü Europrojects during 2011 -2015 n n FP 7: - CREDES (2010 - 2012) n FP 7: Diagnosis, Error Modelling and Correction for Reliable Systems Design - DIAMOND (2011 - 2013) n FP 7: - Innovative, Highly Efficient Road Surface Measurement and Control System - HERMES (2012 - 2014) n ü FP 7: - SAFEMETAL (2010 - 2012) FP 7: BASTION (2014 - 2016) – (CEBE + Testonica Lab) Organized international conferences n Baltic Electronic Conferences (2008, 2010, 2012) n Nordic Test Forum (2011) n IEEE Norchip Conference (2012), IEEE DDECS Workshop (2012) n BELAS – European – Latin. American Workshop (2013) n Hi. PEAC Computing Systems Week (2013) 31

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Partners of CEBE n The © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Cooperation Partners of CEBE n The partners of CEBE in Estonian industry • ELIKO, Artec Group, Smartimplant, Cybernetica AS, National Semiconductor Eesti, Clifton AS, JR Medical, Elcoteq, AS LDI, LDIAMON AS, Emros OÜ, Tensiotrace OÜ, Girf OÜ, AB Medical Teeninduse OÜ, a. o. • 2 clinics , 4 Estonian hospitals n International cooperation • IBM, Ericsson, St. Jude Medical, Boston Scientific, National Semiconductor, Analog Devices, TDI Inc, Göpel Electronic, STMicroelectronics, Aerie. Logic, Trans. Eda, a. o. 32

© Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Concluding Statistics ü Some numbers about © Raimund Ubar Integreeritud elektroonikasüsteemide ja biomeditsiinitehnika tippkeskus Concluding Statistics ü Some numbers about CEBE (last 4/5 years): n 13 international projects (5 FP 7), 25+ national grants n 25 Ph. D thesis defended n 452 publications (170 journal and 273 conf. papers) n Cooperation with 10 industrial partners from Estonia and more than 30 institutions from 15 countries n 15 patents and 11 patent applications n Spin-off companies: 4 (Testonica Lab, Tensiotrace OÜ, Optofluid Technologies OÜ, Prototuba OÜ) n Products: 9 n International evalvation of CEBE (End of 2011) Grade: 5 - Excellent (Application was 4, 5) Thank you! 33