1 Rheumatic illnesses Prepared by: Ergonysova B. E

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1 Rheumatic illnesses Prepared by: Ergonysova B. E    Kenesbek M. A Checked by:1 Rheumatic illnesses Prepared by: Ergonysova B. E Kenesbek M. A Checked by: Tolebaev Zh. A Group: GM 14 -29 —

2 Rheumatic illnesses  --  are the group of diseases in basis of development of2 Rheumatic illnesses — are the group of diseases in basis of development of which is the progressive system disorganization of connecting tissue and vessels, which is predefined by immune violations . .

3 Classification of rheumatic illnesses rheumatism;  rheumatoid arthritis (RA);  lupus erythematosus (LE);  systemic3 Classification of rheumatic illnesses rheumatism; rheumatoid arthritis (RA); lupus erythematosus (LE); systemic scleroderma (SS); nodular periarteritis (NPA) and other systemic vasculites; dermatomyositis; illness (syndrome) of Sjogren; illness of Bechterew (spondylitis deformans).

4 All rheumatic illnesses are combined by the systemic progressive damage of connecting tissue , ,4 All rheumatic illnesses are combined by the systemic progressive damage of connecting tissue , , which is characterized by stages and includes 4 types of changes:

5 Mucoid swelling Stages of disorganization of connecting tissue  Fibrous changes  Cellular reactions (granulomatic5 Mucoid swelling Stages of disorganization of connecting tissue Fibrous changes Cellular reactions (granulomatic inflammation) Sclerosis

6 Rheumatism (Sokolsky-Bouillaud disease)  is the infectiously-allergic disease which is characterized by system disorganization of6 Rheumatism (Sokolsky-Bouillaud disease) is the infectiously-allergic disease which is characterized by system disorganization of connecting tissue with the dominant defeat of the heart-vessels system. An exciter is the ββ — haemolitic streptococcus of group A. 1 -3 % of peoples which had streptococci quinsies will be ill by rheumatism. This mean that is the inclination coupled with X-chromosome. .

7 Clinico-morphologic forms of rheumatism cardiovascular;  polyarthritic;  nodular;  cerebral. 7 Clinico-morphologic forms of rheumatism cardiovascular; polyarthritic; nodular; cerebral.

8 Cardiovascular form of rheumatism Endocarditis : :  valvular, chordal, atparietal; acute diffuse, acute warty,8 Cardiovascular form of rheumatism Endocarditis : : valvular, chordal, atparietal; acute diffuse, acute warty, fibroplastic, relapsing warty Myocarditis : granulomatic (nodular productive), diffuse interstitial exudative, focal interstitial exudative. Pericarditis : serous, serofibrinous, fibrinous. Vasculitis : capillaritis, arteriolaritis, arteritis.

9 Endocarditis  9 Endocarditis

10 The heart tends to  dilate Acute and chronic valvulitis Mural thrombi 10 The heart tends to dilate Acute and chronic valvulitis Mural thrombi

11 Myocarditis  11 Myocarditis

12 Pericardit isis 12 Pericardit isis

13 Polyarthritic form of rheumatism 13 Polyarthritic form of rheumatism

14 Nodular form of rheumatism 14 Nodular form of rheumatism

15 Cerebral form of rheumatism  15 Cerebral form of rheumatism

16 System lupus erythematosus Lupus erythematosus (LE) is chronic polysyndrome disease mostly of young women and16 System lupus erythematosus Lupus erythematosus (LE) is chronic polysyndrome disease mostly of young women and girls, which develops on a background the genetic predefined imperfection of immunoregulatory processes. It results to the uncontrolled productions of antibodies to own tissues and their components with development of autoimmune and immunocomplex chronic inflammation. Morbidity by LE makes 48 -50 cases per 100 thousands of population, death rate – 5, 8 per 1000 000 (at this 4, 7 are women).

17 Symptom of “Butterfly”  17 Symptom of “Butterfly”

18 Endocarditis of Libman-Sacks  18 Endocarditis of Libman-Sacks

19 Rheumatoid arthritis Rheumatoid Arthritis (RA) (polyarthritis)  is the chronic system diseaseof connective tissue with19 Rheumatoid arthritis Rheumatoid Arthritis (RA) (polyarthritis) is the chronic system diseaseof connective tissue with the progressive defeat of peripheral (synovial) joints mostly as the type of erosive-destructive polyarthritis. RR АА is registered in the all countries of the world and all climate-geographical areas with frequency from 0. 6 to 1. 3 %. Everywhere women are unwell more frequent (3 -4: 1).

20 Complication of Rheumatoid Arthritis  20 Complication of Rheumatoid Arthritis

21 Rheumatoid Arthritis 21 Rheumatoid Arthritis

22 Systemic scleroderma (scleriasis) (Progressive systemic sclerosis) Systemic scleroderma is the system disease of connecting tissue22 Systemic scleroderma (scleriasis) (Progressive systemic sclerosis) Systemic scleroderma is the system disease of connecting tissue and small vessels, which is characterized by the widespread fibrotic-sclerotic changes of skin, stromae of internalss and symptomes of obliterated endocarditic in the form of syndrome of Reino. Primary morbidity in the USA is known only – 12 accidents on the 1 million populations in a year. The women are unwell in 3 -7 times more frequent. Age-dependent peak – 30 -60 years.

23 Systemic scleroderma  23 Systemic scleroderma

24 Nodular periarteritis  is is system necrotic vasculitis as the type segmental defeat of small24 Nodular periarteritis is is system necrotic vasculitis as the type segmental defeat of small and middle caliber arteries with formation of the aneurysm protrudes. The men of young age are ill mostly, morbidity makes 2 -3 on the 1 million populations in the year.

25 I thank you for attention  !! 25 I thank you for attention !!